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Volumn 161, Issue 9, 2016, Pages 2449-2455

VRC01 antibody protects against vaginal and rectal transmission of human immunodeficiency virus 1 in hu-BLT mice

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VRC01 MONOCLONAL ANTIBODY;

EID: 84976259402     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-016-2942-4     Document Type: Article
Times cited : (23)

References (42)
  • 1
    • 63849131879 scopus 로고    scopus 로고
    • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
    • COI: 1:CAS:528:DC%2BD1MXjtFCisLc%3D, PID: 19287373
    • Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J et al (2009) Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature 458:636–640
    • (2009) Nature , vol.458 , pp. 636-640
    • Scheid, J.F.1    Mouquet, H.2    Feldhahn, N.3    Seaman, M.S.4    Velinzon, K.5    Pietzsch, J.6
  • 2
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • COI: 1:CAS:528:DC%2BD1MXht1agsbvL, PID: 19729618
    • Walker LM, Phogat SK, Chan-Hui P-Y, Wagner D, Phung P, Goss JL et al (2009) Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326:285–289
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.-Y.3    Wagner, D.4    Phung, P.5    Goss, J.L.6
  • 3
    • 77954920017 scopus 로고    scopus 로고
    • Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    • COI: 1:CAS:528:DC%2BC3cXpvV2hsr0%3D, PID: 20616233
    • Wu X, Yang Z-Y, Li Y, Hogerkorp C-M, Schief WR, Seaman MS et al (2010) Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329:856–861
    • (2010) Science , vol.329 , pp. 856-861
    • Wu, X.1    Yang, Z.-Y.2    Li, Y.3    Hogerkorp, C.-M.4    Schief, W.R.5    Seaman, M.S.6
  • 4
    • 80053132436 scopus 로고    scopus 로고
    • Broad neutralization coverage of HIV by multiple highly potent antibodies
    • COI: 1:CAS:528:DC%2BC3MXhtFers7nM, PID: 21849977
    • Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien J-P et al (2011) Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477:466–470
    • (2011) Nature , vol.477 , pp. 466-470
    • Walker, L.M.1    Huber, M.2    Doores, K.J.3    Falkowska, E.4    Pejchal, R.5    Julien, J.-P.6
  • 5
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • COI: 1:CAS:528:DC%2BC3MXhtFGitb%2FE, PID: 21764753
    • Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TYK et al (2011) Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333:1633–1637
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3    Diskin, R.4    Klein, F.5    Oliveira, T.Y.K.6
  • 6
    • 84866493348 scopus 로고    scopus 로고
    • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
    • Huang J, Ofek G, Laub L, Louder MK, Doria-Rose NA, Longo NS et al (2012) Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature 491:406–412
    • (2012) Nature , vol.491 , pp. 406-412
    • Huang, J.1    Ofek, G.2    Laub, L.3    Louder, M.K.4    Doria-Rose, N.A.5    Longo, N.S.6
  • 7
    • 82755184131 scopus 로고    scopus 로고
    • Increasing the potency and breadth of an HIV antibody by using structure-based rational design
    • COI: 1:CAS:528:DC%2BC3MXhsFCms7nP, PID: 22033520
    • Diskin R, Scheid JF, Marcovecchio PM, West AP, Klein F, Gao H et al (2011) Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science 334:1289–1293
    • (2011) Science , vol.334 , pp. 1289-1293
    • Diskin, R.1    Scheid, J.F.2    Marcovecchio, P.M.3    West, A.P.4    Klein, F.5    Gao, H.6
  • 8
    • 83455254775 scopus 로고    scopus 로고
    • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
    • COI: 1:CAS:528:DC%2BC3MXhsFWqtLjJ, PID: 22113616
    • McLellan JS, Pancera M, Carrico C, Gorman J, Julien J-P, Khayat R et al (2011) Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature 480:336–343
    • (2011) Nature , vol.480 , pp. 336-343
    • McLellan, J.S.1    Pancera, M.2    Carrico, C.3    Gorman, J.4    Julien, J.-P.5    Khayat, R.6
  • 9
    • 84869831194 scopus 로고    scopus 로고
    • Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
    • COI: 1:CAS:528:DC%2BC38XhvValsrvM, PID: 23115339
    • Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF et al (2012) Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci 109:E3268–E3277
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 3268-3277
    • Mouquet, H.1    Scharf, L.2    Euler, Z.3    Liu, Y.4    Eden, C.5    Scheid, J.F.6
  • 10
    • 84870562234 scopus 로고    scopus 로고
    • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
    • COI: 1:CAS:528:DC%2BC38XhsFOmtLnF, PID: 23103874
    • Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S et al (2012) HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 492:118–122
    • (2012) Nature , vol.492 , pp. 118-122
    • Klein, F.1    Halper-Stromberg, A.2    Horwitz, J.A.3    Gruell, H.4    Scheid, J.F.5    Bournazos, S.6
  • 11
    • 77649318846 scopus 로고    scopus 로고
    • Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    • Corti D, Langedijk JP, Hinz A, Seaman MS, Vanzetta F, Fernandez-Rodriguez BM et al (2010) Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. PLoS One 5:0008805
    • (2010) PLoS One , vol.5 , pp. 0008805
    • Corti, D.1    Langedijk, J.P.2    Hinz, A.3    Seaman, M.S.4    Vanzetta, F.5    Fernandez-Rodriguez, B.M.6
  • 12
    • 0345471066 scopus 로고    scopus 로고
    • Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120
    • COI: 1:CAS:528:DC%2BD3sXhsFGgsL0%3D, PID: 12579198
    • Veazey RS, Shattock RJ, Pope M, Kirijan JC, Jones J, Hu Q et al (2003) Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat Med 9:343–346
    • (2003) Nat Med , vol.9 , pp. 343-346
    • Veazey, R.S.1    Shattock, R.J.2    Pope, M.3    Kirijan, J.C.4    Jones, J.5    Hu, Q.6
  • 13
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN et al (2009) Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog 5:15
    • (2009) PLoS Pathog , vol.5 , pp. 15
    • Hessell, A.J.1    Rakasz, E.G.2    Poignard, P.3    Hangartner, L.4    Landucci, G.5    Forthal, D.N.6
  • 14
    • 73949154006 scopus 로고    scopus 로고
    • Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L
    • COI: 1:CAS:528:DC%2BC3cXitFKjsLg%3D, PID: 19906907
    • Hessell AJ, Rakasz EG, Tehrani DM, Huber M, Weisgrau KL, Landucci G et al (2010) Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol 84:1302–1313
    • (2010) J Virol , vol.84 , pp. 1302-1313
    • Hessell, A.J.1    Rakasz, E.G.2    Tehrani, D.M.3    Huber, M.4    Weisgrau, K.L.5    Landucci, G.6
  • 15
    • 0032947286 scopus 로고    scopus 로고
    • Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    • COI: 1:CAS:528:DyaK1MXis1ent74%3D, PID: 10196297
    • Mascola JR, Lewis MG, Stiegler G, Harris D, VanCott TC, Hayes D et al (1999) Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol 73:4009–4018
    • (1999) J Virol , vol.73 , pp. 4009-4018
    • Mascola, J.R.1    Lewis, M.G.2    Stiegler, G.3    Harris, D.4    VanCott, T.C.5    Hayes, D.6
  • 16
    • 0033951746 scopus 로고    scopus 로고
    • Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
    • COI: 1:CAS:528:DC%2BD3cXosF2jtg%3D%3D, PID: 10655111
    • Mascola JR, Stiegler G, VanCott TC, Katinger H, Carpenter CB, Hanson CE et al (2000) Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat Med 6:207–210
    • (2000) Nat Med , vol.6 , pp. 207-210
    • Mascola, J.R.1    Stiegler, G.2    VanCott, T.C.3    Katinger, H.4    Carpenter, C.B.5    Hanson, C.E.6
  • 17
    • 63749100579 scopus 로고    scopus 로고
    • A method for identification of HIV gp140 binding memory B cells in human blood
    • COI: 1:CAS:528:DC%2BD1MXktlymurs%3D, PID: 19100741
    • Scheid JF, Mouquet H, Feldhahn N, Walker BD, Pereyra F, Cutrell E et al (2009) A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods 343:65–67
    • (2009) J Immunol Methods , vol.343 , pp. 65-67
    • Scheid, J.F.1    Mouquet, H.2    Feldhahn, N.3    Walker, B.D.4    Pereyra, F.5    Cutrell, E.6
  • 18
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • COI: 1:CAS:528:DC%2BC38Xhsl2isb3F, PID: 23100539
    • Moldt B, Rakasz EG, Schultz N, Chan-Hui P-Y, Swiderek K, Weisgrau KL et al (2012) Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci USA 109:18921–18925
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18921-18925
    • Moldt, B.1    Rakasz, E.G.2    Schultz, N.3    Chan-Hui, P.-Y.4    Swiderek, K.5    Weisgrau, K.L.6
  • 19
    • 84929613728 scopus 로고    scopus 로고
    • Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection
    • COI: 1:CAS:528:DC%2BC2MXosV2qtbc%3D, PID: 25787288
    • Saunders KO, Pegu A, Georgiev IS, Zeng M, Joyce MG, Yang Z-Y et al (2015) Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection. J Virol 89:5895–5903
    • (2015) J Virol , vol.89 , pp. 5895-5903
    • Saunders, K.O.1    Pegu, A.2    Georgiev, I.S.3    Zeng, M.4    Joyce, M.G.5    Yang, Z.-Y.6
  • 20
    • 84865295305 scopus 로고    scopus 로고
    • Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model
    • COI: 1:CAS:528:DC%2BC38XhtVymsb7L, PID: 22832125
    • Veselinovic M, Preston Neff C, Mulder LR, Akkina R (2012) Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model. Virology 432:505–510
    • (2012) Virology , vol.432 , pp. 505-510
    • Veselinovic, M.1    Preston Neff, C.2    Mulder, L.R.3    Akkina, R.4
  • 21
    • 84869197926 scopus 로고    scopus 로고
    • Animal models for HIV/AIDS research
    • COI: 1:CAS:528:DC%2BC38Xhs1Ogsr3I, PID: 23154262
    • Hatziioannou T, Evans DT (2012) Animal models for HIV/AIDS research. Nat Rev Microbiol 10:852–867
    • (2012) Nat Rev Microbiol , vol.10 , pp. 852-867
    • Hatziioannou, T.1    Evans, D.T.2
  • 22
    • 84880330645 scopus 로고    scopus 로고
    • Nonhuman primate models in AIDS research
    • PID: 23615116
    • Evans DT, Silvestri G (2013) Nonhuman primate models in AIDS research. Curr Opin HIV AIDS 8:255–261
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 255-261
    • Evans, D.T.1    Silvestri, G.2
  • 23
    • 84891641117 scopus 로고    scopus 로고
    • BLT humanized mice as model to study HIV vaginal transmission
    • PID: 24151319
    • Deruaz M, Luster AD (2013) BLT humanized mice as model to study HIV vaginal transmission. J Infect Dis 208(Suppl 2):S131–S136
    • (2013) J Infect Dis , vol.208 , pp. 131-136
    • Deruaz, M.1    Luster, A.D.2
  • 24
    • 33750705617 scopus 로고    scopus 로고
    • Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1
    • COI: 1:CAS:528:DC%2BD28XhtFKlsLbO, PID: 17057712
    • Melkus MW, Estes JD, Padgett-Thomas A, Gatlin J, Denton PW, Othieno FA et al (2006) Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med 12:1316–1322
    • (2006) Nat Med , vol.12 , pp. 1316-1322
    • Melkus, M.W.1    Estes, J.D.2    Padgett-Thomas, A.3    Gatlin, J.4    Denton, P.W.5    Othieno, F.A.6
  • 25
    • 34247392343 scopus 로고    scopus 로고
    • Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1
    • COI: 1:CAS:528:DC%2BD2sXksFSqtbs%3D, PID: 17389241
    • Sun Z, Denton PW, Estes JD, Othieno FA, Wei BL, Wege AK et al (2007) Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med 204:705–714
    • (2007) J Exp Med , vol.204 , pp. 705-714
    • Sun, Z.1    Denton, P.W.2    Estes, J.D.3    Othieno, F.A.4    Wei, B.L.5    Wege, A.K.6
  • 26
    • 84891651815 scopus 로고    scopus 로고
    • Overcoming current limitations in humanized mouse research
    • COI: 1:CAS:528:DC%2BC3sXhs12mtLfM
    • Brehm MA, Shultz LD, Luban J, Greiner DL (2013) Overcoming current limitations in humanized mouse research. J Infect Dis 208:S125–S130
    • (2013) J Infect Dis , vol.208 , pp. 125-130
    • Brehm, M.A.1    Shultz, L.D.2    Luban, J.3    Greiner, D.L.4
  • 27
    • 77954943648 scopus 로고    scopus 로고
    • Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    • COI: 1:CAS:528:DC%2BC3cXpvV2hsrs%3D, PID: 20616231
    • Zhou T, Georgiev I, Wu X, Yang Z-Y, Dai K, Finzi A et al (2010) Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science 329:811–817
    • (2010) Science , vol.329 , pp. 811-817
    • Zhou, T.1    Georgiev, I.2    Wu, X.3    Yang, Z.-Y.4    Dai, K.5    Finzi, A.6
  • 28
    • 84937761089 scopus 로고    scopus 로고
    • Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection
    • COI: 1:CAS:528:DC%2BC2MXmtlOmtLo%3D, PID: 25865483
    • Wu X, Zhang Z, Schramm Chaim A, Joyce MG, Do Kwon Y, Zhou T et al (2015) Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection. Cell 161:470–485
    • (2015) Cell , vol.161 , pp. 470-485
    • Wu, X.1    Zhang, Z.2    Schramm Chaim, A.3    Joyce, M.G.4    Do Kwon, Y.5    Zhou, T.6
  • 29
    • 80052942203 scopus 로고    scopus 로고
    • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    • COI: 1:CAS:528:DC%2BC3MXhtFGitbzP, PID: 21835983
    • Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C et al (2011) Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 333:1593–1602
    • (2011) Science , vol.333 , pp. 1593-1602
    • Wu, X.1    Zhou, T.2    Zhu, J.3    Zhang, B.4    Georgiev, I.5    Wang, C.6
  • 30
    • 84882589754 scopus 로고    scopus 로고
    • Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies
    • COI: 1:CAS:528:DC%2BC3sXht1SrsrrP, PID: 23911655
    • Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P et al (2013) Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity 39:245–258
    • (2013) Immunity , vol.39 , pp. 245-258
    • Zhou, T.1    Zhu, J.2    Wu, X.3    Moquin, S.4    Zhang, B.5    Acharya, P.6
  • 31
    • 84946480939 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults
    • COI: 1:CAS:528:DC%2BC2MXhvVSlsL%2FE, PID: 26332605
    • Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME et al (2015) Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol 182:289–301
    • (2015) Clin Exp Immunol , vol.182 , pp. 289-301
    • Ledgerwood, J.E.1    Coates, E.E.2    Yamshchikov, G.3    Saunders, J.G.4    Holman, L.5    Enama, M.E.6
  • 32
    • 84954445565 scopus 로고    scopus 로고
    • Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
    • PID: 26702094
    • Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P et al (2015) Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med 7:319ra206–319ra206
    • (2015) Sci Transl Med , vol.7 , pp. 319206
    • Lynch, R.M.1    Boritz, E.2    Coates, E.E.3    DeZure, A.4    Madden, P.5    Costner, P.6
  • 33
    • 84896832694 scopus 로고    scopus 로고
    • Humanized-BLT mouse model of Kaposi’s sarcoma-associated herpesvirus infection
    • COI: 1:CAS:528:DC%2BC2cXjtVGrsLY%3D, PID: 24516154
    • Wang LX, Kang G, Kumar P, Lu W, Li Y, Zhou Y et al (2014) Humanized-BLT mouse model of Kaposi’s sarcoma-associated herpesvirus infection. Proc Natl Acad Sci USA 111:3146–3151
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 3146-3151
    • Wang, L.X.1    Kang, G.2    Kumar, P.3    Lu, W.4    Li, Y.5    Zhou, Y.6
  • 34
    • 84937802356 scopus 로고    scopus 로고
    • Early initiation of antiretroviral therapy can functionally control productive HIV-1 infection in humanized-BLT mice
    • COI: 1:CAS:528:DC%2BC2MXhtF2msbjJ, PID: 26167617
    • Li Q, Tso FY, Kang G, Lu W, Li Y, Fan W et al (2015) Early initiation of antiretroviral therapy can functionally control productive HIV-1 infection in humanized-BLT mice. J Acquir Immune Defic Syndr 69:519–527
    • (2015) J Acquir Immune Defic Syndr , vol.69 , pp. 519-527
    • Li, Q.1    Tso, F.Y.2    Kang, G.3    Lu, W.4    Li, Y.5    Fan, W.6
  • 35
    • 73949127978 scopus 로고    scopus 로고
    • Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies
    • COI: 1:CAS:528:DC%2BC3cXitFKjtr4%3D, PID: 19939925
    • Seaman MS, Janes H, Hawkins N, Grandpre LE, Devoy C, Giri A et al (2010) Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies. J Virol 84:1439–1452
    • (2010) J Virol , vol.84 , pp. 1439-1452
    • Seaman, M.S.1    Janes, H.2    Hawkins, N.3    Grandpre, L.E.4    Devoy, C.5    Giri, A.6
  • 36
    • 79957905425 scopus 로고    scopus 로고
    • Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras
    • COI: 1:CAS:528:DC%2BC3MXnsVaitrk%3D, PID: 21576818
    • Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z et al (2011) Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 121:2401–2412
    • (2011) J Clin Invest , vol.121 , pp. 2401-2412
    • Wheeler, L.A.1    Trifonova, R.2    Vrbanac, V.3    Basar, E.4    McKernan, S.5    Xu, Z.6
  • 37
    • 84949921490 scopus 로고    scopus 로고
    • Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous simian immunodeficiency virus vaccine challenge study
    • COI: 1:CAS:528:DC%2BC28XktVGmsro%3D, PID: 26423953
    • Lee FH, Mason R, Welles H, Learn GH, Keele BF, Roederer M et al (2015) Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous simian immunodeficiency virus vaccine challenge study. J Virol 89:12388–12400
    • (2015) J Virol , vol.89 , pp. 12388-12400
    • Lee, F.H.1    Mason, R.2    Welles, H.3    Learn, G.H.4    Keele, B.F.5    Roederer, M.6
  • 38
    • 84907971356 scopus 로고    scopus 로고
    • Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo
    • PID: 25142607
    • Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS et al (2014) Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol 88:12669–12682
    • (2014) J Virol , vol.88 , pp. 12669-12682
    • Rudicell, R.S.1    Kwon, Y.D.2    Ko, S.Y.3    Pegu, A.4    Louder, M.K.5    Georgiev, I.S.6
  • 39
    • 0037029924 scopus 로고    scopus 로고
    • Passive transfer studies to elucidate the role of antibody-mediated protection against HIV-1
    • COI: 1:CAS:528:DC%2BD38Xjt1Srtbo%3D, PID: 11983246
    • Mascola JR (2002) Passive transfer studies to elucidate the role of antibody-mediated protection against HIV-1. Vaccine 20:1922–1925
    • (2002) Vaccine , vol.20 , pp. 1922-1925
    • Mascola, J.R.1
  • 40
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • COI: 1:CAS:528:DC%2BC3MXhsFGktL7E
    • Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D (2012) Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 481:81–84
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 41
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • COI: 1:CAS:528:DC%2BC2cXitFamtLs%3D, PID: 24509526
    • Balazs AB, Ouyang Y, Hong CM, Chen J, Nguyen SM, Rao DS et al (2014) Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med 20:296–300
    • (2014) Nat Med , vol.20 , pp. 296-300
    • Balazs, A.B.1    Ouyang, Y.2    Hong, C.M.3    Chen, J.4    Nguyen, S.M.5    Rao, D.S.6
  • 42
    • 0017913254 scopus 로고
    • A multi-hit model for the neutralization of animal viruses
    • COI: 1:STN:280:DyaE1c%2FovVKjtA%3D%3D, PID: 74400
    • Della-Porta AJ, Westaway EG (1978) A multi-hit model for the neutralization of animal viruses. J Gen Virol 38:1–19
    • (1978) J Gen Virol , vol.38 , pp. 1-19
    • Della-Porta, A.J.1    Westaway, E.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.