Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3146-3151

  Wang, Lin Xu ^a,c   Kang, Guobin ^a   Kumar, Pankaj ^a   Lu, Wuxun ^a   Li, Yue ^a   Zhou, You ^b   Li, Qingsheng ^a   Wood, Charles ^a  

^a UNIVERSITY OF NEBRASKA   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HHV 8; Humanized mice; Mucosa transmission

Indexed keywords

CD45 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE TRANSMISSION; FLOW CYTOMETRY; GENE EXPRESSION; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFECTION; KAPOSI SARCOMA; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE;

HHV-8; HUMANIZED MICE; MUCOSA TRANSMISSION;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE TRANSMISSION, INFECTIOUS; DNA, VIRAL; FLOW CYTOMETRY; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICROSCOPY, FLUORESCENCE; SARCOMA, KAPOSI;

EID: 84896832694     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318175111     Document Type: Article

References (28)

1. Antman K, Chang Y (2000) Kaposi' s sarcoma. N Engl J Med 342(14):1027-1038.
2. Fukumoto H, Kanno T, Hasegawa H, Katano H (2011) Pathology of Kaposi's sarcoma-associated herpesvirus infection. Front Microbiol 2:175.
3. Tamburro KM, et al. (2012) Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology 433(1):220-225.
4. Picchio GR, et al. (1997) The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft. Virology 238(1):22-29. (Pubitemid 27497258)
5. Foreman KE, et al. (2001) Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions. J Dermatol Sci 26(3):182-193. (Pubitemid 32487638)
6. Dittmer D, et al. (1999) Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med 190(12):1857-1868. (Pubitemid 30013851)
7. WuW, et al. (2006) KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: Persistence of infection during hematopoiesis in vitro and in vivo. Blood 108(1):141-151. (Pubitemid 43990622)
8. Parsons CH, et al. (2006) KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice. J Clin Invest 116(7):1963-1973. (Pubitemid 44033320)
9. Brehm MA, Shultz LD, Greiner DL (2010) Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes 17(2):120-125.
10. Woodfin A, Voisin MB, Nourshargh S (2007) PECAM-1: A multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol 27(12):2514-2523. (Pubitemid 350158900)
11. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL (2012) Humanized mice for immune system investigation: Progress, promise and challenges. Nat Rev Immunol 12(11):786-798.
12. Akkina R (2013) New generation humanized mice for virus research: Comparative aspects and future prospects. Virology 435(1):14-28.
13. Jaiswal S, et al. (2012) Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology 136(3):334-343.
14. Biswas S, et al. (2012) Humoral immune responses in humanized BLT mice immunized withWest Nile virus and HIV-1 envelope proteins are largelymediated via human CD5(+) B cells (vol 134, pg 419, 2011). Immunology 136(3):361.
15. Renne R, et al. (2004) Experimental transmission of Kaposi' s sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol 33(1):1-9. (Pubitemid 38256426)
16. Chang H, et al. (2009) Non-human primate model of Kaposi's sarcoma-associated herpesvirus infection. PLoS Pathog 5(10):e1000606.
17. Akkina R (2013) Human immune responses and potential for vaccine assessment in humanized mice. Curr Opin Immunol 25(3):403-409.
18. Austgen K, Oakes SA, Ganem D (2012) Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells. J Virol 86(3):1877-1882.
19. Tian X, et al. (2009) Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells 27(11):2675-2685.
20. Brainard DM, et al. (2009) Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol 83(14):7305-7321.
21. Wang QJ, et al. (2001) Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins. Blood 97(8):2366-2373. (Pubitemid 32291483)
22. Roncarolo MG, Carballido JM (2001) Construction of human-SCID chimeric mice. Curr Protoc Immunol Chapter 4p Unit 4.8.
23. Vieira J, O'Hearn PM (2004) Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325(2):225-240. (Pubitemid 38902789)
24. Mantina H, et al. (2001) Vertical transmission of Kaposi's sarcoma-associated herpesvirus. Int J Cancer 94(5):749-752. (Pubitemid 33035697)
25. Li QS, et al. (2005) Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434(7037):1148-1152.
26. Reeves RK, et al. (2012) SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa. J Infect Dis 206(9):1462-1468.
27. Li QS, Gebhard K, Schacker T, Henry K, Haase AT (1997) The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue. J Virol 71(9):7080-7082. (Pubitemid 27355374)
28. Stagg AJ, Burke F, Hill S, Knight SC (2001) Isolation of mouse spleen dendritic cells. Methods Mol Med 64:9-22.