메뉴 건너뛰기




Volumn 2, Issue 2, 2014, Pages

The cure: Design and evaluation of a crowdsourcing game for gene selection for breast cancer survival prediction

Author keywords

Artificial intelligence; Breast neoplasms; Collaborative and social computing systems and tools; Computer games; Crowdsourcing; Feature selection; Gene expression; Supervised learning; Survival analysis; Web applications

Indexed keywords


EID: 84975860751     PISSN: None     EISSN: 22919279     Source Type: Journal    
DOI: 10.2196/games.3350     Document Type: Article
Times cited : (26)

References (29)
  • 1
    • 84872853140 scopus 로고    scopus 로고
    • Global estimates of cancer prevalence for 27 sites in the adult population in 2008
    • Mar 1; [doi] [Medline: 22752881]
    • Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 2013 Mar 1; 132(5):1133-1145. [doi: 10.1002/ijc.27711] [Medline: 22752881]
    • (2013) Int J Cancer , vol.132 , Issue.5 , pp. 1133-1145
    • Bray, F1    Ren, JS2    Masuyer, E3    Ferlay, J.4
  • 2
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • Jan 31; [doi] [Medline: 11823860]
    • van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002 Jan 31; 415(6871):530-536. [doi: 10.1038/415530a] [Medline: 11823860]
    • (2002) Nature , vol.415 , Issue.6871 , pp. 530-536
    • van 't Veer, LJ1    Dai, H2    van de Vijver, MJ3    He, YD4    Hart, AA5    Mao, M6
  • 3
    • 84877765675 scopus 로고    scopus 로고
    • Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer
    • Apr 17; [FREE Full text] [doi] [Medline: 23596205]
    • Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, et al. Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Sci Transl Med 2013 Apr 17; 5(181):181re1 [FREE Full text] [doi: 10.1126/scitranslmed.3006112] [Medline: 23596205]
    • (2013) Sci Transl Med , vol.5 , Issue.181 , pp. 181re1
    • Margolin, AA1    Bilal, E2    Huang, E3    Norman, TC4    Ottestad, L5    Mecham, BH6
  • 4
    • 84885369269 scopus 로고    scopus 로고
    • A robust prognostic signature for hormone-positive node-negative breast cancer
    • [FREE Full text] [doi] [Medline: 24112773]
    • Griffith OL, Pepin F, Enache OM, Heiser LM, Collisson EA, Spellman PT, et al. A robust prognostic signature for hormone-positive node-negative breast cancer. Genome Med 2013; 5(10):92 [FREE Full text] [doi: 10.1186/gm496] [Medline: 24112773]
    • (2013) Genome Med , vol.5 , Issue.10 , pp. 92
    • Griffith, OL1    Pepin, F2    Enache, OM3    Heiser, LM4    Collisson, EA5    Spellman, PT6
  • 5
    • 84906213716 scopus 로고    scopus 로고
    • Modeling precision treatment of breast cancer
    • [FREE Full text] [doi] [Medline: 24176112]
    • Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, et al. Modeling precision treatment of breast cancer. Genome Biol 2013; 14(10):R110 [FREE Full text] [doi: 10.1186/gb-2013-14-10-r110] [Medline: 24176112]
    • (2013) Genome Biol , vol.14 , Issue.10 , pp. R110
    • Daemen, A1    Griffith, OL2    Heiser, LM3    Wang, NJ4    Enache, OM5    Sanborn, Z6
  • 6
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • May; [FREE Full text] [doi] [Medline: 18515733]
    • Ross JS, Hatzis C, Symmans WF, Pusztai L, Hortobágyi GN. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist 2008 May; 13(5):477-493 [FREE Full text] [doi: 10.1634/theoncologist.2007-0248] [Medline: 18515733]
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, JS1    Hatzis, C2    Symmans, WF3    Pusztai, L4    Hortobágyi, GN.5
  • 7
    • 84655161546 scopus 로고    scopus 로고
    • Challenges translating breast cancer gene signatures into the clinic
    • Jan; [doi] [Medline: 21878891]
    • Weigelt B, Pusztai L, Ashworth A, Reis-Filho JS. Challenges translating breast cancer gene signatures into the clinic. Nat Rev Clin Oncol 2012 Jan; 9(1):58-64. [doi: 10.1038/nrclinonc.2011.125] [Medline: 21878891]
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.1 , pp. 58-64
    • Weigelt, B1    Pusztai, L2    Ashworth, A3    Reis-Filho, JS.4
  • 8
    • 84877737214 scopus 로고    scopus 로고
    • Development of a prognostic model for breast cancer survival in an open challenge environment
    • Apr 17; [FREE Full text] [doi] [Medline: 23596202]
    • Cheng WY, Ou Yang TH, Anastassiou D. Development of a prognostic model for breast cancer survival in an open challenge environment. Sci Transl Med 2013 Apr 17; 5(181):181ra50 [FREE Full text] [doi: 10.1126/scitranslmed.3005974] [Medline: 23596202]
    • (2013) Sci Transl Med , vol.5 , Issue.181 , pp. 181ra50
    • Cheng, WY1    Ou Yang, TH2    Anastassiou, D.3
  • 9
    • 80053446196 scopus 로고    scopus 로고
    • Protein networks as logic functions in development and cancer
    • Sep; [FREE Full text] [doi] [Medline: 21980275]
    • Dutkowski J, Ideker T. Protein networks as logic functions in development and cancer. PLoS Comput Biol 2011 Sep; 7(9):e1002180 [FREE Full text] [doi: 10.1371/journal.pcbi.1002180] [Medline: 21980275]
    • (2011) PLoS Comput Biol , vol.7 , Issue.9 , pp. e1002180
    • Dutkowski, J1    Ideker, T.2
  • 10
    • 84863677563 scopus 로고    scopus 로고
    • Google goes cancer: Improving outcome prediction for cancer patients by network-based ranking of marker genes
    • [FREE Full text] [doi] [Medline: 22615549]
    • Winter C, Kristiansen G, Kersting S, Roy J, Aust D, Knösel T, et al. Google goes cancer: Improving outcome prediction for cancer patients by network-based ranking of marker genes. PLoS Comput Biol 2012; 8(5):e1002511 [FREE Full text] [doi: 10.1371/journal.pcbi.1002511] [Medline: 22615549]
    • (2012) PLoS Comput Biol , vol.8 , Issue.5 , pp. e1002511
    • Winter, C1    Kristiansen, G2    Kersting, S3    Roy, J4    Aust, D5    Knösel, T6
  • 11
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Jan 19; [doi] [Medline: 16273092]
    • Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006 Jan 19; 439(7074):353-357. [doi: 10.1038/nature04296] [Medline: 16273092]
    • (2006) Nature , vol.439 , Issue.7074 , pp. 353-357
    • Bild, AH1    Yao, G2    Chang, JT3    Wang, Q4    Potti, A5    Chasse, D6
  • 12
    • 77949524863 scopus 로고    scopus 로고
    • Accurate and reliable cancer classification based on probabilistic inference of pathway activity
    • [FREE Full text] [doi] [Medline: 19997592]
    • Su J, Yoon BJ, Dougherty ER. Accurate and reliable cancer classification based on probabilistic inference of pathway activity. PLoS One 2009; 4(12):e8161 [FREE Full text] [doi: 10.1371/journal.pone.0008161] [Medline: 19997592]
    • (2009) PLoS One , vol.4 , Issue.12 , pp. e8161
    • Su, J1    Yoon, BJ2    Dougherty, ER.3
  • 13
    • 84874763866 scopus 로고    scopus 로고
    • Biomolecular events in cancer revealed by attractor metagenes
    • [FREE Full text] [doi] [Medline: 23468608]
    • Cheng WY, Ou Yang TH, Anastassiou D. Biomolecular events in cancer revealed by attractor metagenes. PLoS Comput Biol 2013; 9(2):e1002920 [FREE Full text] [doi: 10.1371/journal.pcbi.1002920] [Medline: 23468608]
    • (2013) PLoS Comput Biol , vol.9 , Issue.2 , pp. e1002920
    • Cheng, WY1    Ou Yang, TH2    Anastassiou, D.3
  • 14
    • 85102488633 scopus 로고    scopus 로고
    • [accessed 2014-02-24] [WebCite Cache ID 6NdE37LPi]
    • PubMed search for breast cancer. URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=((breast+cancer))+AND+(%222000%22%5BDate+-+Publication%5D+%3A+%223000%22%5BDate+-+Publication%5D) [accessed 2014-02-24] [WebCite Cache ID 6NdE37LPi]
    • PubMed search for breast cancer
  • 15
    • 84880973546 scopus 로고    scopus 로고
    • Crowdsourcing for bioinformatics
    • Aug 15; [doi] [Medline: 23782614]
    • Good BM, Su AI. Crowdsourcing for bioinformatics. Bioinformatics 2013 Aug 15; 29(16):1925-1933. [doi: 10.1093/bioinformatics/btt333] [Medline: 23782614]
    • (2013) Bioinformatics , vol.29 , Issue.16 , pp. 1925-1933
    • Good, BM1    Su, AI.2
  • 16
    • 49249119915 scopus 로고    scopus 로고
    • Designing games with a purpose
    • Aug 01; [doi]
    • von Ahn L, Dabbish L. Designing games with a purpose. Commun. ACM 2008 Aug 01; 51(8):57-67. [doi: 10.1145/1378704.1378719]
    • (2008) Commun. ACM , vol.51 , Issue.8 , pp. 57-67
    • von Ahn, L1    Dabbish, L.2
  • 17
    • 77955491294 scopus 로고    scopus 로고
    • Predicting protein structures with a multiplayer online game
    • Aug 5; [FREE Full text] [doi] [Medline: 20686574]
    • Cooper S, Khatib F, Treuille A, Barbero J, Lee J, Beenen M, et al. Predicting protein structures with a multiplayer online game. Nature 2010 Aug 5; 466(7307):756-760 [FREE Full text] [doi: 10.1038/nature09304] [Medline: 20686574]
    • (2010) Nature , vol.466 , Issue.7307 , pp. 756-760
    • Cooper, S1    Khatib, F2    Treuille, A3    Barbero, J4    Lee, J5    Beenen, M6
  • 18
    • 84863230440 scopus 로고    scopus 로고
    • Phylo: A citizen science approach for improving multiple sequence alignment
    • [FREE Full text] [doi] [Medline: 22412834]
    • Kawrykow A, Roumanis G, Kam A, Kwak D, Leung C, Wu C, Phylo players, et al. Phylo: A citizen science approach for improving multiple sequence alignment. PLoS One 2012; 7(3):e31362 [FREE Full text] [doi: 10.1371/journal.pone.0031362] [Medline: 22412834]
    • (2012) PLoS One , vol.7 , Issue.3 , pp. e31362
    • Kawrykow, A1    Roumanis, G2    Kam, A3    Kwak, D4    Leung, C5    Wu, C6    Phylo, players7
  • 19
    • 84872434718 scopus 로고    scopus 로고
    • Crowdsourcing malaria parasite quantification: An online game for analyzing images of infected thick blood smears
    • [FREE Full text] [doi] [Medline: 23196001]
    • Luengo-Oroz MA, Arranz A, Frean J. Crowdsourcing malaria parasite quantification: An online game for analyzing images of infected thick blood smears. J Med Internet Res 2012; 14(6):e167 [FREE Full text] [doi: 10.2196/jmir.2338] [Medline: 23196001]
    • (2012) J Med Internet Res , vol.14 , Issue.6 , pp. e167
    • Luengo-Oroz, MA1    Arranz, A2    Frean, J.3
  • 20
    • 0031381525 scopus 로고    scopus 로고
    • Wrappers for feature subset selection
    • Dec; [doi]
    • Kohavi R, John GH. Wrappers for feature subset selection. Artificial Intelligence 1997 Dec; 97(1-2):273-324. [doi: 10.1016/S0004-3702(97)00043-X]
    • (1997) Artificial Intelligence , vol.97 , Issue.1-2 , pp. 273-324
    • Kohavi, R1    John, GH.2
  • 21
    • 85102526055 scopus 로고    scopus 로고
    • io9. [accessed 2014-06-17] [WebCite Cache ID 6QP1ukCNC]
    • Yesilbas A. io9. These-cool-games-let-you-do-real-life-scienceURL: http://io9.com/these-cool-games-let-you-do-real-life-science-486173006 [accessed 2014-06-17] [WebCite Cache ID 6QP1ukCNC]
    • These-cool-games-let-you-do-real-life-scienceURL
    • Yesilbas, A.1
  • 22
    • 76349106192 scopus 로고    scopus 로고
    • User contribution and trust in wikipedia
    • IEEE; Presented at: CollaborateCom; 2009; Washington D.C [doi]
    • Javanmardi S, Ganjisaffar Y, Lopes C, Baldi P. User contribution and trust in wikipedia. In: Collaborative Computing: Networking, Applications and Worksharing.: IEEE; 2009 Presented at: CollaborateCom; 2009; Washington D.C p. 1-6 URL: http://pensivepuffin.com/dwmcphd/syllabi/info447_wi14/readings/07-WikipediaTrust/javanmardi-TrustInWikipedia. CollaborateCon2009.pdf [doi: 10.4108/ICST.COLLABORATECOM2009.8376]
    • (2009) Collaborative Computing: Networking, Applications and Worksharing , pp. 1-6
    • Javanmardi, S1    Ganjisaffar, Y2    Lopes, C3    Baldi, P.4
  • 23
    • 84880617636 scopus 로고    scopus 로고
    • Web-based gene set analysis toolkit (WebGestalt): Update 2013
    • Jul; (Web Server issue): [FREE Full text] [doi] [Medline: 23703215]
    • Wang J, Duncan D, Shi Z, Zhang B. Web-based gene set analysis toolkit (WebGestalt): Update 2013. Nucleic Acids Res 2013 Jul; 41(Web Server issue):W77-W83 [FREE Full text] [doi: 10.1093/nar/gkt439] [Medline: 23703215]
    • (2013) Nucleic Acids Res , vol.41 , pp. W77-W83
    • Wang, J1    Duncan, D2    Shi, Z3    Zhang, B.4
  • 24
    • 34447132081 scopus 로고    scopus 로고
    • Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen
    • Jun; [FREE Full text] [doi] [Medline: 17602054]
    • Paik S. Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen. Oncologist 2007 Jun; 12(6):631-635 [FREE Full text] [doi: 10.1634/theoncologist.12-6-631] [Medline: 17602054]
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 631-635
    • Paik, S.1
  • 25
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
    • METABRIC Group Jun 21; [FREE Full text] [doi] [Medline: 22522925]
    • Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, METABRIC Group, et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature 2012 Jun 21; 486(7403):346-352 [FREE Full text] [doi: 10.1038/nature10983] [Medline: 22522925]
    • (2012) Nature , vol.486 , Issue.7403 , pp. 346-352
    • Curtis, C1    Shah, SP2    Chin, SF3    Turashvili, G4    Rueda, OM5    Dunning, MJ6
  • 26
    • 44849092828 scopus 로고    scopus 로고
    • Consensus genes of the literature to predict breast cancer recurrence
    • Jul; [doi] [Medline: 17899371]
    • Lauss M, Kriegner A, Vierlinger K, Visne I, Yildiz A, Dilaveroglu E, et al. Consensus genes of the literature to predict breast cancer recurrence. Breast Cancer Res Treat 2008 Jul; 110(2):235-244. [doi: 10.1007/s10549-007-9716-3] [Medline: 17899371]
    • (2008) Breast Cancer Res Treat , vol.110 , Issue.2 , pp. 235-244
    • Lauss, M1    Kriegner, A2    Vierlinger, K3    Visne, I4    Yildiz, A5    Dilaveroglu, E6
  • 27
    • 80055090025 scopus 로고    scopus 로고
    • Most random gene expression signatures are significantly associated with breast cancer outcome
    • Oct; [FREE Full text] [doi] [Medline: 22028643]
    • Venet D, Dumont JE, Detours V. Most random gene expression signatures are significantly associated with breast cancer outcome. PLoS Comput Biol 2011 Oct; 7(10):e1002240 [FREE Full text] [doi: 10.1371/journal.pcbi.1002240] [Medline: 22028643]
    • (2011) PLoS Comput Biol , vol.7 , Issue.10 , pp. e1002240
    • Venet, D1    Dumont, JE2    Detours, V.3
  • 28
    • 85102498210 scopus 로고    scopus 로고
    • The Cure game website. [accessed 2014-02-24] [WebCite Cache ID 6NdDULq2v]
    • The Cure game website. URL: http://genegames.org/cure/[accessed 2014-02-24] [WebCite Cache ID 6NdDULq2v]
  • 29
    • 85102504203 scopus 로고    scopus 로고
    • [accessed 2014-02-24] [WebCite Cache ID 6NdEQWw3D]
    • Open source code repository for The Cure. URL: https://bitbucket.org/sulab/thecure/[accessed 2014-02-24] [WebCite Cache ID 6NdEQWw3D]
    • Open source code repository for The Cure


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.