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Volumn 150, Issue 7, 2016, Pages 1646-1658.e17

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

Author keywords

Immune Response; Liver Cancer; Mouse Model; Neovascularization

Indexed keywords

CD66B ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; PROTEIN KINASE B; SHORT HAIRPIN RNA; SORAFENIB; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE;

EID: 84975797403     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.02.040     Document Type: Article
Times cited : (637)

References (51)
  • 1
    • 84895826238 scopus 로고    scopus 로고
    • CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils
    • S.L. Zhou, Z. Dai, Z.J. Zhou, and et al. CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils Carcinogenesis 35 2014 597 605
    • (2014) Carcinogenesis , vol.35 , pp. 597-605
    • Zhou, S.L.1    Dai, Z.2    Zhou, Z.J.3
  • 2
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • D.F. Quail, and J.A. Joyce Microenvironmental regulation of tumor progression and metastasis Nat Med 19 2013 1423 1437
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 3
    • 84874117229 scopus 로고    scopus 로고
    • Protumor and antitumor functions of neutrophil granulocytes
    • S. Brandau, C.A. Dumitru, and S. Lang Protumor and antitumor functions of neutrophil granulocytes Semin Immunopathol 35 2013 163 176
    • (2013) Semin Immunopathol , vol.35 , pp. 163-176
    • Brandau, S.1    Dumitru, C.A.2    Lang, S.3
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 84875492465 scopus 로고    scopus 로고
    • Tumor associated macrophages and neutrophils in tumor progression
    • M.R. Galdiero, C. Garlanda, S. Jaillon, and et al. Tumor associated macrophages and neutrophils in tumor progression J Cell Physiol 228 2013 1404 1412
    • (2013) J Cell Physiol , vol.228 , pp. 1404-1412
    • Galdiero, M.R.1    Garlanda, C.2    Jaillon, S.3
  • 6
    • 84876990066 scopus 로고    scopus 로고
    • Immunomonitoring and prognostic relevance of neutrophils in clinical trials
    • F. Donskov Immunomonitoring and prognostic relevance of neutrophils in clinical trials Semin Cancer Biol 23 2013 200 207
    • (2013) Semin Cancer Biol , vol.23 , pp. 200-207
    • Donskov, F.1
  • 7
    • 84870514368 scopus 로고    scopus 로고
    • Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma
    • S.L. Zhou, Z. Dai, Z.J. Zhou, and et al. Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma Hepatology 56 2012 2242 2254
    • (2012) Hepatology , vol.56 , pp. 2242-2254
    • Zhou, S.L.1    Dai, Z.2    Zhou, Z.J.3
  • 8
    • 84876978607 scopus 로고    scopus 로고
    • On the cytokines produced by human neutrophils in tumors
    • C. Tecchio, P. Scapini, G. Pizzolo, and et al. On the cytokines produced by human neutrophils in tumors Semin Cancer Biol 23 2013 159 170
    • (2013) Semin Cancer Biol , vol.23 , pp. 159-170
    • Tecchio, C.1    Scapini, P.2    Pizzolo, G.3
  • 9
    • 42949174616 scopus 로고    scopus 로고
    • Diagnosis and treatment of hepatocellular carcinoma
    • H.B. El-Serag, J.A. Marrero, L. Rudolph, and et al. Diagnosis and treatment of hepatocellular carcinoma Gastroenterology 134 2008 1752 1763
    • (2008) Gastroenterology , vol.134 , pp. 1752-1763
    • El-Serag, H.B.1    Marrero, J.A.2    Rudolph, L.3
  • 10
    • 65249134427 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma: A further step toward personalized therapy of liver cancer
    • M. Colombo Sorafenib in advanced hepatocellular carcinoma: a further step toward personalized therapy of liver cancer Gastroenterology 136 2009 1832 1835
    • (2009) Gastroenterology , vol.136 , pp. 1832-1835
    • Colombo, M.1
  • 11
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • J.M. Llovet, S. Ricci, V. Mazzaferro, and et al. Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 12
    • 33745684092 scopus 로고    scopus 로고
    • Pitfalls in the classification of liver tumors
    • C. Wittekind [Pitfalls in the classification of liver tumors] Pathologe 27 2006 289 293
    • (2006) Pathologe , vol.27 , pp. 289-293
    • Wittekind, C.1
  • 13
    • 84921611532 scopus 로고    scopus 로고
    • CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3beta/Snail signaling
    • S.L. Zhou, Z.J. Zhou, Z.Q. Hu, and et al. CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3beta/Snail signaling Cancer Lett 358 2015 124 135
    • (2015) Cancer Lett , vol.358 , pp. 124-135
    • Zhou, S.L.1    Zhou, Z.J.2    Hu, Z.Q.3
  • 14
    • 84901273062 scopus 로고    scopus 로고
    • HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL
    • Z.J. Zhou, Z. Dai, S.L. Zhou, and et al. HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL Cancer Res 74 2014 2750 2762
    • (2014) Cancer Res , vol.74 , pp. 2750-2762
    • Zhou, Z.J.1    Dai, Z.2    Zhou, S.L.3
  • 15
    • 44449085884 scopus 로고    scopus 로고
    • Design and endpoints of clinical trials in hepatocellular carcinoma
    • J.M. Llovet, A.M. Di Bisceglie, J. Bruix, and et al. Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 2008 698 711
    • (2008) J Natl Cancer Inst , vol.100 , pp. 698-711
    • Llovet, J.M.1    Di Bisceglie, A.M.2    Bruix, J.3
  • 16
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • B.Z. Qian, J. Li, H. Zhang, and et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis Nature 475 2011 222 225
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3
  • 18
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • C. Murdoch, M. Muthana, S.B. Coffelt, and et al. The role of myeloid cells in the promotion of tumour angiogenesis Nat Rev Cancer 8 2008 618 631
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3
  • 19
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • A. Facciabene, X. Peng, I.S. Hagemann, and et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells Nature 475 2011 226 230
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3
  • 20
    • 0035941196 scopus 로고    scopus 로고
    • ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells
    • A.C. Keates, S. Keates, J.H. Kwon, and et al. ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells J Biol Chem 276 2001 43713 43722
    • (2001) J Biol Chem , vol.276 , pp. 43713-43722
    • Keates, A.C.1    Keates, S.2    Kwon, J.H.3
  • 21
    • 69249220253 scopus 로고    scopus 로고
    • Hypoxia. Regulation of NFkappaB signalling during inflammation: The role of hydroxylases
    • K.M. Oliver, C.T. Taylor, and E.P. Cummins Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases Arthritis Res Ther 11 2009 215
    • (2009) Arthritis Res Ther , vol.11 , pp. 215
    • Oliver, K.M.1    Taylor, C.T.2    Cummins, E.P.3
  • 22
    • 79960829290 scopus 로고    scopus 로고
    • Neutrophils in the activation and regulation of innate and adaptive immunity
    • A. Mantovani, M.A. Cassatella, C. Costantini, and et al. Neutrophils in the activation and regulation of innate and adaptive immunity Nat Rev Immunol 11 2011 519 531
    • (2011) Nat Rev Immunol , vol.11 , pp. 519-531
    • Mantovani, A.1    Cassatella, M.A.2    Costantini, C.3
  • 23
    • 80054757504 scopus 로고    scopus 로고
    • Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop
    • Y. Wu, Q. Zhao, C. Peng, and et al. Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop J Pathol 225 2011 438 447
    • (2011) J Pathol , vol.225 , pp. 438-447
    • Wu, Y.1    Zhao, Q.2    Peng, C.3
  • 24
    • 0037444169 scopus 로고    scopus 로고
    • Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: Role in tumor progression and death
    • M. Wislez, N. Rabbe, J. Marchal, and et al. Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death Cancer Res 63 2003 1405 1412
    • (2003) Cancer Res , vol.63 , pp. 1405-1412
    • Wislez, M.1    Rabbe, N.2    Marchal, J.3
  • 25
    • 25444497706 scopus 로고    scopus 로고
    • Breast cancer cells stimulate neutrophils to produce oncostatin M: Potential implications for tumor progression
    • M.M. Queen, R.E. Ryan, R.G. Holzer, and et al. Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression Cancer Res 65 2005 8896 8904
    • (2005) Cancer Res , vol.65 , pp. 8896-8904
    • Queen, M.M.1    Ryan, R.E.2    Holzer, R.G.3
  • 26
    • 70449722821 scopus 로고    scopus 로고
    • Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1
    • C. Strell, K. Lang, B. Niggemann, and et al. Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1 Exp Cell Res 316 2010 138 148
    • (2010) Exp Cell Res , vol.316 , pp. 138-148
    • Strell, C.1    Lang, K.2    Niggemann, B.3
  • 27
    • 76249101753 scopus 로고    scopus 로고
    • Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth
    • A.M. Houghton, D.M. Rzymkiewicz, H. Ji, and et al. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth Nat Med 16 2010 219 223
    • (2010) Nat Med , vol.16 , pp. 219-223
    • Houghton, A.M.1    Rzymkiewicz, D.M.2    Ji, H.3
  • 28
    • 79954657385 scopus 로고    scopus 로고
    • Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma
    • D.M. Kuang, Q. Zhao, Y. Wu, and et al. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma J Hepatol 54 2011 948 955
    • (2011) J Hepatol , vol.54 , pp. 948-955
    • Kuang, D.M.1    Zhao, Q.2    Wu, Y.3
  • 29
    • 84892149953 scopus 로고    scopus 로고
    • Neutrophils promote the malignant glioma phenotype through S100A4
    • J. Liang, Y. Piao, L. Holmes, and et al. Neutrophils promote the malignant glioma phenotype through S100A4 Clin Cancer Res 20 2014 187 198
    • (2014) Clin Cancer Res , vol.20 , pp. 187-198
    • Liang, J.1    Piao, Y.2    Holmes, L.3
  • 31
    • 79955784400 scopus 로고    scopus 로고
    • MCP-1: Chemoattractant with a role beyond immunity: A review
    • A. Yadav, V. Saini, and S. Arora MCP-1: chemoattractant with a role beyond immunity: a review Clin Chim Acta 411 2010 1570 1579
    • (2010) Clin Chim Acta , vol.411 , pp. 1570-1579
    • Yadav, A.1    Saini, V.2    Arora, S.3
  • 32
    • 84880570170 scopus 로고    scopus 로고
    • Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: A retrospective analysis
    • Y. Mano, K. Shirabe, Y. Yamashita, and et al. Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis Ann Surg 258 2013 301 305
    • (2013) Ann Surg , vol.258 , pp. 301-305
    • Mano, Y.1    Shirabe, K.2    Yamashita, Y.3
  • 33
    • 84900335537 scopus 로고    scopus 로고
    • A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
    • S. Su, Q. Liu, J. Chen, and et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis Cancer Cell 25 2014 605 620
    • (2014) Cancer Cell , vol.25 , pp. 605-620
    • Su, S.1    Liu, Q.2    Chen, J.3
  • 34
    • 71849099109 scopus 로고    scopus 로고
    • Targeted knock down of CCL22 and CCL17 by siRNA during DC differentiation and maturation affects the recruitment of T subsets
    • S. Kang, J. Xie, S. Ma, and et al. Targeted knock down of CCL22 and CCL17 by siRNA during DC differentiation and maturation affects the recruitment of T subsets Immunobiology 215 2010 153 162
    • (2010) Immunobiology , vol.215 , pp. 153-162
    • Kang, S.1    Xie, J.2    Ma, S.3
  • 35
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • Q. Gao, S.J. Qiu, J. Fan, and et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection J Clin Oncol 25 2007 2586 2593
    • (2007) J Clin Oncol , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.J.2    Fan, J.3
  • 36
    • 84876956206 scopus 로고    scopus 로고
    • Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression
    • C.A. Dumitru, S. Lang, and S. Brandau Modulation of neutrophil granulocytes in the tumor microenvironment: mechanisms and consequences for tumor progression Semin Cancer Biol 23 2013 141 148
    • (2013) Semin Cancer Biol , vol.23 , pp. 141-148
    • Dumitru, C.A.1    Lang, S.2    Brandau, S.3
  • 37
    • 84876743991 scopus 로고    scopus 로고
    • Hypoxia-mediated sorafenib resistance can be overcome by EF24 through von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma
    • Y. Liang, T. Zheng, R. Song, and et al. Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma Hepatology 57 2013 1847 1857
    • (2013) Hepatology , vol.57 , pp. 1847-1857
    • Liang, Y.1    Zheng, T.2    Song, R.3
  • 38
    • 84862692712 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells
    • M.J. Blivet-Van Eggelpoel, H. Chettouh, L. Fartoux, and et al. Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells J Hepatol 57 2012 108 115
    • (2012) J Hepatol , vol.57 , pp. 108-115
    • Blivet-Van Eggelpoel, M.J.1    Chettouh, H.2    Fartoux, L.3
  • 39
    • 84887488381 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and sorafenib: Too many resistance mechanisms?
    • C. Berasain Hepatocellular carcinoma and sorafenib: too many resistance mechanisms? Gut 62 2013 1674 1675
    • (2013) Gut , vol.62 , pp. 1674-1675
    • Berasain, C.1
  • 40
    • 84872517083 scopus 로고    scopus 로고
    • Anti-angiogenesis and metastasis: A tumour and stromal cell alliance
    • L. Moserle, and O. Casanovas Anti-angiogenesis and metastasis: a tumour and stromal cell alliance J Intern Med 273 2013 128 137
    • (2013) J Intern Med , vol.273 , pp. 128-137
    • Moserle, L.1    Casanovas, O.2
  • 41
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not?
    • K. De Bock, M. Mazzone, and P. Carmeliet Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat Rev Clin Oncol 8 2011 393 404
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 42
    • 84874084734 scopus 로고    scopus 로고
    • Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma
    • V. Hernandez-Gea, S. Toffanin, S.L. Friedman, and et al. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma Gastroenterology 144 2013 512 527
    • (2013) Gastroenterology , vol.144 , pp. 512-527
    • Hernandez-Gea, V.1    Toffanin, S.2    Friedman, S.L.3
  • 43
    • 84866018690 scopus 로고    scopus 로고
    • TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • P. Yang, Q.J. Li, Y. Feng, and et al. TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma Cancer Cell 22 2012 291 303
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.J.2    Feng, Y.3
  • 44
    • 84856018299 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils
    • R.S. Czepielewski, B.N. Porto, L.B. Rizzo, and et al. Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils Proc Natl Acad Sci U S A 109 2012 547 552
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 547-552
    • Czepielewski, R.S.1    Porto, B.N.2    Rizzo, L.B.3
  • 45
    • 0142092620 scopus 로고    scopus 로고
    • Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
    • K. Goodarzi, M. Goodarzi, A.M. Tager, and et al. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues Nat Immunol 4 2003 965 973
    • (2003) Nat Immunol , vol.4 , pp. 965-973
    • Goodarzi, K.1    Goodarzi, M.2    Tager, A.M.3
  • 46
    • 0034235785 scopus 로고    scopus 로고
    • High-dose and long-term therapy with interferon-alfa inhibits tumor growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential
    • L. Wang, Z.Y. Tang, L.X. Qin, and et al. High-dose and long-term therapy with interferon-alfa inhibits tumor growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential Hepatology 32 2000 43 48
    • (2000) Hepatology , vol.32 , pp. 43-48
    • Wang, L.1    Tang, Z.Y.2    Qin, L.X.3
  • 47
    • 0032742269 scopus 로고    scopus 로고
    • New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    • J. Tian, Z.Y. Tang, S.L. Ye, and et al. New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis Br J Cancer 81 1999 814 821
    • (1999) Br J Cancer , vol.81 , pp. 814-821
    • Tian, J.1    Tang, Z.Y.2    Ye, S.L.3
  • 48
    • 80052775556 scopus 로고    scopus 로고
    • Tacrolimus enhances the invasion potential of hepatocellular carcinoma cells and promotes lymphatic metastasis in a rat model of hepatocellular carcinoma: Involvement of vascular endothelial growth factor-C
    • S. Zhou, C. Tan, Z. Dai, and et al. Tacrolimus enhances the invasion potential of hepatocellular carcinoma cells and promotes lymphatic metastasis in a rat model of hepatocellular carcinoma: involvement of vascular endothelial growth factor-C Transplant Proc 43 2011 2747 2754
    • (2011) Transplant Proc , vol.43 , pp. 2747-2754
    • Zhou, S.1    Tan, C.2    Dai, Z.3
  • 49
    • 84863625224 scopus 로고    scopus 로고
    • A CXCL1 paracrine network links cancer chemoresistance and metastasis
    • S. Acharyya, T. Oskarsson, S. Vanharanta, and et al. A CXCL1 paracrine network links cancer chemoresistance and metastasis Cell 150 2012 165 178
    • (2012) Cell , vol.150 , pp. 165-178
    • Acharyya, S.1    Oskarsson, T.2    Vanharanta, S.3
  • 50
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • Q. Gao, S.J. Qiu, J. Fan, and et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection J Clin Oncol 25 2007 2586 2593
    • (2007) J Clin Oncol , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.J.2    Fan, J.3
  • 51
    • 79951677462 scopus 로고    scopus 로고
    • Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection
    • Y.W. Li, S.J. Qiu, J. Fan, and et al. Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection J Hepatol 54 2011 497 505
    • (2011) J Hepatol , vol.54 , pp. 497-505
    • Li, Y.W.1    Qiu, S.J.2    Fan, J.3


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