Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Wang, Cuifeng ^a   De Jong, Edwin ^a   Sjollema, Klaas A ^a   Zuhorn, Inge S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

POLYETHYLENEIMINE; POLYMER; POLYPHOSPHOINOSITIDE;

ANIMAL; CELL POLARITY; CHEMISTRY; DOG; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ENDOCYTOSIS; EPITHELIUM CELL; GENE TRANSFER; GENETICS; HUMAN; MDCK CELL LINE; PATHOGENICITY; PSEUDOMONAS AERUGINOSA;

ANIMALS; CELL POLARITY; DOGS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; EPITHELIAL CELLS; GENE TRANSFER TECHNIQUES; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; PHOSPHATIDYLINOSITOL PHOSPHATES; POLYETHYLENEIMINE; POLYMERS; PSEUDOMONAS AERUGINOSA;

EID: 84975784116     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21436     Document Type: Article

References (30)

1. Cereijido, M., Ponce, A. & Gonzalez-Mariscal, L. Tight Junctions and Apical/Basolateral Polarity. J. Membrane Biol. 110, 1-9 (1989).
2. Matter, K. & Mellman, I. Mechanisms of cell polarity: sorting and transport in epithelial cells. Curr. Opin. Cell Biol. 6, 545-554 (1994).
3. Bucior, I., Mostov, K. & Engel, J. N. Pseudomonas aeruginosa-Mediated Damage Requires Distinct Receptors at the Apical and Basolateral Surfaces of the Polarized Epithelium. Infect. Immun. 78, 939-953 (2010).
4. Kierbel, A. et al. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. J. Cell Biol. 177, 21-27 (2007).
5. Lepanto, P. et al. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyndependent mechanism. Cell Microbiol. 13, 1212-1222 (2011).
6. Shewan, A., Eastburn, D. J. & Mostov, K. Phosphoinositides in Cell Architecture. Cold Spring Harb. Perspect. Biol. 3, 1-17 (2011).
7. Gassama-Diagne, A. et al. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat. Cell Biol. 8, 963-970 (2006).
8. Parsons, D. W., Grubb, B. R., Johnson, L. G. & Boucher, R. C. Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent. Hum. Gene Ther. 9, 2661-2672 (1998).
9. Wang, G. et al. Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. Am. J. Respir. Cell Mol. Biol. 22, 129-138 (2000).
10. Chu, Q., St. George, J. M., Cheng, S. H., Scheule, R. K. & Eastman, S. J. EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo. Hum. Gene Ther. 12, 455-467 (2001).
11. Zuhorn, I. S., Kalicharan, D., Robillard, G. T. & Hoekstra, D. Adhesion receptors mediate efficient non-viral gene delivery. Mol. Ther. 15, 946-953 (2007).
12. Behr, J. P., Demeneix, B., Loeffler, J. P. & Perez-Mutul, J. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. 86, 6982-6986 (1989).
13. Demeneix, B. & Behr, J. P. Polyethylenimine (PEI). Adv. Genet. 53, 217-230 (2005).
14. Rehman, Z. U., Hoekstra, D. & Zuhorn, I. S. Mechanism of Polyplex-and Lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. ACS Nano 7, 3767-3777 (2013).
15. Ozaki, S., DeWald, D. B., Shope, J. C., Chen, J. & Prestwich, G. D. Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc. Natl. Acad. Sci. 97, 11286-11291 (2000).
16. Wang, C. et al. Poly(α-glutamic acid) combined with polycation as serum-resistant carriers for gene delivery. Int. J. Pharm. 398, 237-245 (2010).
17. Wang, C. et al. Influence of the polyanion on the physico-chemical properties and biological activities of polyanion/DNA/polycation ternary polyplexes. Acta Biomater. 8, 3014-3026 (2012).
18. Cantley, L. C. The phosphoinositide 3-kinase pathway. Science 296, 1655-1657 (2002).
19. Chi, P. & Liu, H. Molecular signaling and cellular pathways for virus entry. ISRN Virology 2013, 1-8 (2013).
20. Pellinen, T. & Ivaska, J. Integrin traffic. J. Cell Sci. 119, 3723-3731 (2006).
21. Izmailyan, R. et al. Integrin β 1 mediates vaccinia virus entry through activation of PI3K/Akt signaling. J. Virol. 86, 6677-6687 (2012).
22. Bernfield, M. et al. Biology of the syndecans: a family of transmembrane heparn sulfate proteoglycans. Annu. Rev. Cell Biol. 8, 365-393 (1992).
23. Paris, S., Burlacu, A. & Durocher, Y. Opposing roles of syndecan-1 and syndecan-2 in polyethyleneimine-mediated gene delivery. J. Biol. Chem. 283, 7697-7704 (2008).
24. Rehman, Z. U., Sjollema, K. A., Kuipers, J., Hoekstra, D. & Zuhorn, I. S. Nonviral gene delivery vectors use syndecan-dependent transport mechanisms in filopodia to reach the cell surface. ACS Nano 6, 7521-7532 (2012).
25. Günther, M. et al. Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung. Eur. J. Pharm. Biopharm. 77, 438-449 (2011).
26. Fuller, S. D. & Simons, K. Transferrin receptor polarity and recycling accuracy in "tight" and "leaky" strains of Madin-Darby Canine Kidney cells. J. Cell Biol. 103, 1767-1779 (1986).
27. Agarwala, A., Unferb, R. & Mallapragada, S. K. Novel cationic pentablock copolymers as non-viral vectors for gene therapy. J. Control. Release 103, 245-258 (2005).
28. Pack, D. W., Hoffman, A. S., Pun, S. & Stayton, P. S. Design and development of polymers for gene delivery. Nat. Rew. Drug Discov. 4, 581-593 (2005).
29. Vuillaume, P. et al. Tail-end amphiphilic dimethylaminopyridinium-containing polymethacrylates for gene delivery. New J. Chem. 33, 1941-1950 (2009).
30. Mortimer, I. et al. Cationic lipid-mediated transfection of cells in culture requires mitotic activity. Gene Ther. 6, 403-411 (1999).