The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Nhu, Nguyen Thi Khanh ^a,b   Riordan, David W ^c   Nhu, Tran Do Hoang ^a   Thanh, Duy Pham ^a   Thwaites, Guy ^a,d   Lan, Nguyen Phu Huong ^e   Wren, Brendan W ^c   Baker, Stephen ^a,c,d   Stabler, Richard A ^c  

^a OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; COLISTIN;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MUTATION; VIET NAM;

ACINETOBACTER BAUMANNII; BACTERIAL PROTEINS; COLISTIN; DRUG RESISTANCE, BACTERIAL; HUMANS; MUTATION; VIETNAM;

EID: 84975775542     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28291     Document Type: Article

References (47)

1. Bergogne-Berezin, E., & Towner, K. J. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clinical Microbiology Reviews 9, 148-165 (1996
2. Dijkshoorn, L., Nemec, A., & Seifert, H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nature reviews. Microbiology 5, 939-951, doi: 10.1038/nrmicro1789 (2007
3. Menon, T., Shanmugasundaram, S., Nandhakumar, B., Nalina, K., & Balasubramaniam. Infective endocarditis due to Acinetobacter baumannii complex-A case report. Indian Journal of Pathology & Microbiology 49, 576-578 (2006
4. Sturiale, M., Corpina, C., & Sturiale, L. Endocarditis due to Acinetobacter baumannii. International Journal of Cardiology 209 161-163, doi: 10.1016/j.ijcard.2014.10.098 (2016
5. Sebeny, P. J., Riddle, M. S., & Petersen, K. Acinetobacter baumannii skin and soft-tissue infection associated with war trauma. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 47, 444-449, doi: 10.1086/590568 (2008
6. Davis, K. A., Moran, K. A., McAllister, C. K., & Gray, P. J. Multidrug-resistant Acinetobacter extremity infections in soldiers. Emerging Infectious Diseases 11, 1218-1224, doi: 10.3201/eid1108.050103 (2005
7. Tong, M. J. Septic complications of war wounds. JAMA: the journal of the American Medical Association 219, 1044-1047 (1972
8. Koulenti, D. et al. Spectrum of practice in the diagnosis of nosocomial pneumonia in patients requiring mechanical ventilation in European intensive care units. Crit Care Med 37, 2360-2368, doi: 10.1097/CCM.0b013e3181a037ac (2009
9. Nhu, N. T. et al. Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-Associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam. J Med Microbiol 63, 1386-1394, doi 10.1099/jmm.0.076646-0 (2014
10. Karageorgopoulos, D. E., & Falagas, M. E. Current control and treatment of multidrug-resistant Acinetobacter baumannii infections. Lancet Infect Dis 8, 751-762, doi: 10.1016/S1473-3099(08)70279-2 (2008
11. Bergogne-Berezin, E., & Towner, K. J. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clinical Microbiology Reviews 9, 148-165 (1996
12. Van Looveren, M., & Goossens, H. Antimicrobial resistance of Acinetobacter spp. in Europe. Clin Microbiol Infect 10, 684-704, doi 10.1111/j.1469-0691.2004.00942.x (2004
13. Evans, M. E., Feola, D. J., & Rapp, R. P. Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. The Annals of Pharmacotherapy 33, 960-967 (1999
14. Beceiro, A. et al. Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system. Antimicrobial Agents and Chemotherapy 55, 3370-3379, doi: 10.1128/AAC.00079-11 (2011
15. Adams, M. D. et al. Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrobial Agents and Chemotherapy 53, 3628-3634, doi: 10.1128/AAC.00284-09 (2009
16. Gunn, J. S. et al. PmrA-PmrB-regulated genes necessary for 4-Aminoarabinose lipid A modification and polymyxin resistance. Molecular Microbiology 27, 1171-1182 (1998
17. Gunn, J. S., Ryan, S. S., Van Velkinburgh, J. C., Ernst, R. K., & Miller, S. I. Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium. Infection and Immunity 68, 6139-6146 (2000
18. Wand, M. E., Bock, L. J., Bonney, L. C., & Sutton, J. M. Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance. The Journal of Antimicrobial Chemotherapy 70, 2209-2216, doi: 10.1093/jac/dkv097 (2015
19. Park, Y. K., Choi, J. Y., Shin, D., & Ko, K. S. Correlation between overexpression and amino acid substitution of the PmrAB locus and colistin resistance in Acinetobacter baumannii. International Journal of Antimicrobial Agents 37, 525-530, doi: 10.1016/j.ijantimicag.2011.02.008 (2011
20. Moffatt, J. H. et al. Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrobial Agents and Chemotherapy 54, 4971-4977, doi: 10.1128/AAC.00834-10 (2010
21. Hood, M. I., Becker, K. W., Roux, C. M., Dunman, P. M., & Skaar, E. P. Genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii. Infection and Immunity 81, 542-551, doi: 10.1128/IAI.00704-12 (2013
22. Liu, Y. Y. et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis, doi: 10.1016/S1473-3099(15)00424-7 (2015
23. Malhotra-Kumar, S. et al. Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam. Lancet Infect Dis, doi: 10.1016/S1473-3099(16)00014-1 (2016
24. Davenport, K. W. et al. Draft Genome Assembly of Acinetobacter baumannii ATCC 19606. Genome Announcements 2, doi: 10.1128/genomeA.00832-14 (2014
25. Turton, J. F. et al. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. Journal of Clinical Microbiology 44, 2974-2976, doi: 10.1128/JCM.01021-06 (2006
26. Gao, F. et al. Genome sequence of Acinetobacter baumannii MDR-TJ. Journal of Bacteriology 193, 2365-2366, doi: 10.1128/JB.00226-11 (2011
27. Huang, H. et al. Complete genome sequence of Acinetobacter baumannii MDR-TJ and insights into its mechanism of antibiotic resistance. The Journal of Antimicrobial Chemotherapy 67, 2825-2832, doi: 10.1093/jac/dks327 (2012
28. Lesho, E. et al. Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections. The Journal of Infectious Diseases 208, 1142-1151, doi: 10.1093/infdis/jit293 (2013
29. Park, J. Y. et al. Complete genome sequence of multidrug-resistant Acinetobacter baumannii strain 1656-2, which forms sturdy biofilm. Journal of Bacteriology 193, 6393-6394, doi: 10.1128/JB.06109-11 (2011
30. Adams, M. D. et al. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. Journal of Bacteriology 190, 8053-8064, doi: 10.1128/JB.00834-08 (2008
31. Beceiro, A. et al. Biological Cost of Different Mechanisms of Colistin Resistance and Their Impact on Virulence in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy 58, 518-526, doi: 10.1128/AAC.01597-13 (2014
32. Carpenter, C. D. et al. The Vps/VacJ ABC transporter is required for intercellular spread of Shigella flexneri. Infection and Immunity 82, 660-669, doi: 10.1128/IAI.01057-13 (2014
33. Takaku, C. et al. Campylobacter lari: molecular and comparative analyses of the virulence-Associated chromosome locus J (vacJ) gene homologue, including the promoter region. Br J Biomed Sci 66, 85-92 (2009
34. Malinverni, J. C., & Silhavy, T. J. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proceedings of the National Academy of Sciences of the United States of America 106, 8009-8014, doi: 10.1073/pnas.0903229106 (2009
35. Hu, W. S., Lin, J. F., Lin, Y. H., & Chang, H. Y. Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Antimicrobial Agents and Chemotherapy 53, 3248-3255, doi 10.1128/AAC.00079-09 (2009
36. Hong, M., Gleason, Y., Wyckoff, E. E., & Payne, S. M. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Infection and Immunity 66, 4700-4710 (1998
37. Audet, A., Nantel, G., & Proulx, P. Phospholipase A activity in growing Escherichia coli cells. Biochimica et Biophysica Acta 348 334-343 (1974
38. Roma-Rodrigues, C., Santos, P. M., Benndorf, D., Rapp, E., & Sa-Correia, I. Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome. Journal of Proteomics 73, 1461-1478, doi: 10.1016/j.jprot.2010.02.003 (2010
39. Woodford, N. et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. International Journal of Antimicrobial Agents 27, 351-353, doi: 10.1016/j.ijantimicag.2006.01.004 (2006
40. Bolger, A. M., Lohse, M., & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics, doi: 10.1093/bioinformatics/btu170 (2014
41. Zerbino, D. R., & Birney, E. Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Research 18, 821-829 doi: 10.1101/gr.074492.107 (2008
42. Assefa, S., Keane, T. M., Otto, T. D., Newbold, C., & Berriman, M. ABACAS: algorithm-based automatic contiguation of assembled sequences. Bioinformatics 25, 1968-1969, doi: 10.1093/bioinformatics/btp347 (2009
43. Tsai, I. J., Otto, T. D., & Berriman, M. Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gaps. Genome Biology 11, R41, doi: 10.1186/gb-2010-11-4-r41 (2010
44. Seemann, T. Prokka: rapid prokaryotic genome annotation. Bioinformatics 30, 2068-2069, doi: 10.1093/bioinformatics/btu153 (2014
45. Li, H., & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760, doi 10.1093/bioinformatics/btp324 (2009
46. Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079, doi: 10.1093/bioinformatics/btp352 (2009
47. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. Basic local alignment search tool. J Mol Biol 215, 403-410, doi 10.1016/S0022-2836(05)80360-2 (1990