Detection of Subtle Cognitive Changes after mTBI Using a Novel Tablet-Based Task

Journal of Neurotrauma

Volumn 33, Issue 13, 2016, Pages 1237-1246

  Fischer, Tara D ^a   Red, Stuart D ^a   Chuang, Alice Z ^b   Jones, Elizabeth B ^a   McCarthy, James J ^a   Patel, Saumil S ^c   Sereno, Anne B ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

assessment tools; behavioral assessment; cognitive function; head trauma; outcome measures

Indexed keywords

ADULT; AGED; ANTIPOINT TASK; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; COGNITIVE FUNCTION TEST; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; INTERMETHOD COMPARISON; MALE; PRO POINT TASK; RECEIVER OPERATING CHARACTERISTIC; RESPONSE TIME; SENSITIVITY AND SPECIFICITY; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY; BRAIN CONCUSSION; COMPLICATION; EYE MOVEMENT; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PERSONAL DIGITAL ASSISTANT; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; STANDARDS; YOUNG ADULT;

ADULT; BRAIN CONCUSSION; COGNITIVE DYSFUNCTION; COMPUTERS, HANDHELD; EYE MOVEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84975769703     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2015.3990     Document Type: Article

References (64)

1. Faul, M., Xu, L., Wald, M.M., and Coronado, V.G. (2010). Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths 2002-2006. Centers for Disease Control and Prevention: Atlanta, GA.
2. Centers for Disease Control and Prevention. (2003). Report to Congress on mild traumatic brain injury in the United States: steps to prevent a serious public health problem. Available at: www.cdc.gov/ traumaticbraininjury/pdf/mtbireport-a.pdf. Accessed September 26, 2015.
3. Bigler, E. (2013). Neuroimaging biomarkers in mild traumatic brain injury (mTBI). Neuropsychol. Rev. 23, 169-209.
4. Borich, M. R., Cheung, K. L., Jones, P., Khramova, V., Gavrailoff, L., Boyd, L.A, and Virji-Babul, N. (2013). Concussion: current concepts in diagnosis and management. J. Neurol. Phys. Ther. 37, 133-9.
5. Levin, H.S. and Diaz-Arrastia, R.R. (2015). Diagnosis, prognosis, and clinical management of mild traumatic brain injury. Lancet Neurol. 14, 506-517.
6. Iverson, G.L. (2005). Outcome from mild traumatic brain injury. Curr. Opin. Psychiatry 18, 301-317.
7. McCauley, S. R., Boake, C., Pedroza, C., Brown, S. A., Levin, H. S., Goodman, H. S., and Merritt, S.G. (2008). Correlates of persistent postconcussional disorder: DSM-IV criteria versus ICD-10. J. Clin. Exp. Neuropsychol. 30, 360-379.
8. Meares, Susanne, Shores, Arthur E., Taylor, Alan J., Batchelor, Jennifer, Gurka, Joseph, and Marosszeky, J.E. (2011). The prospective course of postconcussion syndrome: The role of mild traumatic brain injury. Neuropsychology 25, 454-465.
9. Ingebrigsten, T., Waterloo, L., Marup-Jensen, S., Attner, E., and Romner, B. (1998). Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients. J. Neurol. 245, 609-612.
10. Sheedy, J. Harvey, E., Faux, S., Geffen, G., and Shores, E. (2009). Emergency department assessment of mild traumatic brain injury and the prediction of postconcussive symptoms: A 3-month prospective study. J. Head Trauma Rehabil. 24, 33-43.
11. Waljas, M., Lange, R.T., Haulinen, U., Huhtala, H., Dastidar, P., Hartikainen, K., Ohman, J., and Iverson, G.L. (2014). Biopsychosocial outcome after uncomplicated mild traumatic brain injury. J. Neurotrauma 31, 108-124.
12. Mounce, L.T., Williams, W.H., Jones, J.M., Harris, A., Haslam, S.A., and Jetten, J. (2013). Neurogenic and psychogenic acute postconcussion symptoms can be identified after mild traumatic brain injury. J. Head Trauma Rehabil. 28, 397-405.
13. Ponsford, J., Willmott, C., Rothwell, A., Cameron, P., Kelly, A.M., Nelms, R., Curran, C., and Ng, K. (2000). Factors influencing outcome following mild traumatic brain injury in adults. J. Int. Neuropsychol. Soc. 6, 568-579.
14. Ponsford, J., Cameron, P., Fitzgerald, M., Grant, M., and Mikock-Walus, A. (2011). Long-term outcomes after uncomplicated mild traumatic brain injury: A comparison with trauma controls. J. Neurotrauma 28, 937-946.
15. Reuben, A, Sampson, P, Harris, AR, Williams, H, and Yates, P. (2014). Postconcussion syndrome (PCS) in the emergency department: predicting and pre-empting persistent symptoms following a mild traumatic brain injury. Emerg. Med. J. 31, 72-77.
16. Eierud, C., Craddock, C., Fletcher, S., Aulakh, M., King-Casas, B., Kuehl, D., and LaConte, S.M. (2014). Neuroimaging after mild traumatic brain injury: review and meta-analysis. NeuroImage Clin. 4, 283-294.
17. Tate, D.F., Shenton, M.E., and Bigler, E. (2012). Introduction to the brain imaging and behavior special issue on neuroimaging findings in mild traumatic brain injury. Brain Imaging Behav. 2, 103-107.
18. Panenka, W.J., Lange, R.T., Bouix, S., Shewchuk, J.R., Heran, M.K., Brubacher, J.R., Eckbo, R., Shenton, M.E., and Iverson, G. (2015). Neuropsychological outcome and diffusion tensor imaging in complicated versus uncomplicated mild traumatic brain injury. PLoS One 10.
19. Shenton, M.E., Hamoda, H.M., Schneiderman, J.S., Bouix, S., Pasternak, O., Rathi, Y., Vu, M.A., Purohit, M.P., Helmer, K., Koerte, I., Lin, A.P., Westin, C.F., Kikinis, R., Kubicki, M., Stern, R.A., and Zafonte, R. (2012). A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav. 6, 137-192.
20. Kim, N., Branch, C.A., Kim, M., and Lipton, M. (2013). Whole brain approaches for identification of microstructural abnormalities in individual patients: comparison of techniques applied to mild traumatic brain injury. PLoS One 8.
21. Hasan, K.M., Wilde, E.A., Miller, E.R., Patel, K.V., Staewen, T.D., Frisby, M.L., Garza, H.M., McCarthy, J.J., Hunter, J.V., Levin, H.S., Robertson, C.S., and Narayana, P. (2014). Serial atlas-based diffusion tensor imaging study of uncomplicated mild traumatic brain injury in adults. J. Neurotrauma 31, 466-475.
22. Hugenholtz, H., Stuss, D.T., Stethem, L.L., and Richard, M. (1988). How long does it take to recover from a mild concussion? Neurosurgery 22, 853-858.
23. Leigh, R.J. and Zee, D.S. (1999). The Neurology of Eye Movements. 3rd ed. Oxford University Press: New York.
24. Kaminski, H.J. and Leigh, R.J. (2002). Neurobiology of eye movements. From molecules to behavior. Foreward. Ann. N.Y. Acad Sci. 956, xiii.
25. Leigh, R. J. and Kennard, C. (2004). Using saccades as a research tool in the clinical neurosciences. Brain 124, 460-477.
26. Everling, S. and Fischer, B. (1998). The antisaccade: A review of basic research and clinical studies. Neuropsychologia 36, 855-899.
27. Hallett, P.E. (1978). Primary and secondary saccades to goals defined by instructions. Vision Res. 18, 1279-1296.
28. Munoz, D. P. and Everling, S. (2004). Look away: the anti-saccade task and the voluntary control of eye movement. Nat. Rev. Neurosci. 5, 218-228.
29. Hutton, S.B. (2008). Cognitive control of saccadic eye movements. Brain Cogn. 68, 327-40.
30. Sereno, A.B., Babin, S.L., Hood, A.J., and Jeter, C.B. (2009). Executive functions: Eye movements and neuropsychiatric disorders. in: Encyclopedia of Neuroscience, Volume 4. L.R. Squire (ed). Elsevier: UK, pps. 117-122.
31. Murray, E.A., Bussey, T.J., and Wise, S.P. (2000). Role of prefrontal cortex in a network for arbitrary visumotor mapping. Exp. Brain Res. 133, 114-129.
32. Guitton, D., Buchtel, H.A., and Douglas, R.M. (1985). Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Exp. Brain Res. 58, 455-472.
33. Koken, P.W. and Erkelens, C. (1992). Influences of hand movements on eye movements in tracking tasks in man. Exp. Brain Res. 88, 657-664.
34. Ariff, G., Donchin, O., Nanayakkara, T., and Shadmehr, R. (2002). A real-time state predictor in motor control: study of saccadic eye movements during unseen reaching movements. J. Neurosci 22, 7721-7729.
35. Carey, DP, Della Sala, S, and Ietswaart, M. (2002). Neuropsychological perspectives on eye-hand coordination in visually-guided reaching. Prog. Brain Res. 140, 311-327.
36. Muri, R.M., Kaluzny, P., Nirkko, A., Frosch, M., and Wiesendanger, M. (1999). Eye-hand coordination in uni-and bimanual goal-oriented tasks. Exp. Brain Res. 128, 200-204.
37. Heitger, M.H., Anderson, T.J., and Jones, R.D. (2002). Saccade sequences as markers for cerebral dysfunction following mild closed head injury. Prog. Brain Res. 140, 433-48.
38. Heitger, M.H., Anderson, T.J., Jones, R.D., Dalrymple-Alford, J.C., Frampton, C.M., and Ardagh, M.W. (2004). Eye movement and visuomotor arm movement deficits following mild closed head injury. Brain 127, 575-90.
39. Heitger, M.H., Jones, R.D., Dalrymple-Alford, J.C., Frampton, C.M., Ardagh, M.W., andAnderson, T.J. (2006).Motor deficits and recovery during the first year following mild closed head injury. Brain Inj. 20, 807-24.
40. Heitger,M.H., Jones, R.D.,Macleod, A.D., Snell, D.L., Frampton, C.M., and Anderson, T.J. (2009). Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain 132, 2850-2870.
41. Maruta, J., Suh, M., Niogi, S. N., Mukherjee, P., and Ghajar, J. (2010). Visual tracking synchronization as a metric for concussion screening. J. Head Trauma Rehabil. 25, 293-305.
42. Mullen, S.J., Yucel, Y.H., Cusimano, M., Schweizer, T.A., Oentoro, A., and Gupta, N. (2014). Saccadic eye movements in mild traumatic brain injury: A pilot study. Can. J. Neurol. Sci. 41, 58-65.
43. Cifu, D.X., Wares, J.R., Hoke, K.W., Wetzel, P.A., Gitchel, G., and Carne, W. (2014). Differential eye movements in mild traumatic brain injury versus normal controls. J. Head Trauma Rehabil. 30, 21-28.
44. Galetta, K., Barrett, J., Allen, M., and Madda, F. (2011). The King-Devick test as a determinant of head trauma and concussion in boxers and MMA fighters. Neurology 76, 1456-62.
45. Galetta, K.M., Brandes, L.E., Maki, K., Dziemianowicz, M.S., Laudano, E., Allen, M., and Balcer, L.J. (2011). The King-Devick test and sports-related concussion: study of a rapid visual screening tool in a collegiate cohort. J. Neurol. Sci. 309, 34-39.
46. Galetta, M.S., Galetta, K.M., McCrossin, J., Wilson, J.A, Moster, S., Galetta, S.L., and Master, C.L. (2013). Saccades and memory: baseline associations of the King-Devick and SCAT2 SAC tests in professional ice hockey players. J. Neurol. Sci. 328, 18-31.
47. Rabinowitz, A. R., Li, X., and Levin, H.S. (2013). Sport and nonsport etiologies of mild traumatic brain injury: similarities and differences. Annu. Rev. Psychol. 65, 301-331.
48. Shatz, P., Pardini, J.E., Lovell, M.R., Collins, M.W., and Podell, K. (2006). Sensitivity and specificity of the ImPACT Test Battery for concussion in athletes. Arch. Clin. Neuropsychol. 1, 91-99.
49. Zhang, M.R., Red, S.D., Lin, A.H., Patel, S.S., and Sereno, A.B. (2013). Evidence of cognitive dysfunction after soccer playing with ball heading using a novel tablet-based approach. PLoS One 8.
50. Funahashi, S., Chafee, M.V., and Goldman-Rakic, P.S. (1993). Prefrontal neuronal activity in rhesus monkeys performing a delayed antisaccade task. Nature 365, 753-756.
51. Desouza, J.F., Menon, R.S., and Everling, S. (2003). Preparatory set associated with pro-saccades and anti-saccades in humans investigated with event-related FMRI. J. Neurophysiol. 89, 1016-1023.
52. McCrea, M. (2001). Standardized mental status testing on the sideline after sport-related concussion. J. Athl. Train. 36, 274-279.
53. Heck, J. and Rosa, R. (2001). Evaluating mild head injury: Incorporating the standardized assessment of concussion. Sport. Med. Updat. 15, 46-52.
54. Naunheim, R.S., Matero, D., and Fucetola, R. (2008). Assessment of patients with mild concussion in the emergency department. J. Head Trauma Rehabil. 23, 116-122.
55. Teasdale, G. and Jennet, B. (1974). Assessment of coma and impaired consciousness: A practical scale. Lancet 2, 81-84.
56. Baker, S.P., O'Neill, B., Haddon, W. Jr., and Long, W. (1974). The Injury Severity Score: A method for describing patients with multiple injuries and evaluating emergency care. J. Trauma 14, 187-196.
57. Taylor, K.S., Anastakis, D.J., and Davis, K.D. (2010). Chronic pain and sensorimotor deficits following peripheral nerve injury. Pain 151, 582-591.
58. Moriarty, O., McGuire, B.E., and Finn, D.P. (2011). The effect of pain on cognitive function: A review of clinical and preclinical research. Prog. Neurobiol. 93, 385-404.
59. Stuss, D.T., Stethem, L.L., Hugenholtz, H, Picton, T., Pivik, K., and Richard, M. (1989). Reaction time after head injury: fatigue, divided and focused attention, and consistency of performance. J. Neurol. Neurosurg. Psychiatry 52, 742-748.
60. Stuss, D.T., Stethem, L.L., Hugenholtz, H., Picton, T., Leech, E.E., and Pelchat, G. (1989). Traumatic brain injury, aging and reaction time. Can. J. Neurol. Sci. 16, 161-167.
61. Segalowitz, S.J., Dywan, J., and Unsal, A. (1997). Attentional factors in response time variability after traumatic brain injury: An ERP study. J. Int. Neuropsychol. Soc. 3, 95-107.
62. Piponnier, J.C., Forget, R., Gagnon, I., McKerral, M., Giguere, J.F., and Faubert, J. (2015). First-and second-order stimuli reaction time measures are highly sensitive to mild traumatic brain injuries. 2015 Aug 31; Epub ahead of print.
63. Barr, W. B. and McCrea, M. (2001). Sensitivity and specificity of standardized neurocognitive testing immediately following sports concussion. J. Int. Neuropsychol. Soc. 7, 693-702.
64. Silverberg, N.D., Luoto, T.M., Öhman, J., and Iverson, G.L. (2014). Assessment of mild traumatic brain injury with the King-Devick Test in an emergency department sample. Brain Inj. 5, 1-4.