Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator

Neuropharmacology

Volumn 108, Issue , 2016, Pages 111-119

  Gregg, Ryan A ^a   Hicks, Callum ^a   Nayak, Sunil U ^a   Tallarida, Christopher S ^a   Nucero, Paul ^a   Smith, Garry R ^b   Reitz, Allen B ^b   Rawls, Scott M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Fox Chase Chemical Diversity Center   (United States)

Author keywords

Bath salts; Behavioral sensitization; Cathinone; Ceftriaxone; Conditioned place preference; GLT 1; Glutamate; MDPV

Indexed keywords

3,4 METHYLENEDIOXYPYROVALERONE; CATHINONE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; 1,3 BENZODIOXOLE DERIVATIVE; 3,4-METHYLENEDIOXYPYROVALERONE; ALKALOID; CEFTRIAXONE; EXCITATORY AMINO ACID TRANSPORTER 2; PYRROLIDINE DERIVATIVE; SLC1A2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CONTROLLED STUDY; DOWN REGULATION; LOCOMOTION; MALE; NEUROCHEMISTRY; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REWARD; SENSITIZATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ALKALOIDS; ANIMALS; BENZODIOXOLES; CEFTRIAXONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID TRANSPORTER 2; LOCOMOTION; MALE; PYRROLIDINES; RATS; REWARD;

EID: 84975733498     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.04.014     Document Type: Article

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