Arrhythmic risk assessment in genotyped families with arrhythmogenic right ventricular cardiomyopathy

Europace

Volumn 18, Issue 4, 2016, Pages 610-616

  Protonotarios, Alexandros ^a   Anastasakis, Aris ^b   Panagiotakos, Demosthenes B ^c   Antoniades, Loizos ^d   Syrris, Petros ^e   Vouliotis, Apostolos ^b   Stefanadis, Christodoulos ^b   Tsatsopoulou, Adalena ^a   McKenna, William J ^e   Protonotarios, Nikos ^a  

^a Yannis Protonotarios Medical Centre   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c HAROKOPIO UNIVERSITY   (Greece)

^d Larnaca General Hospital   (Cyprus)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arrhythmia; Arrhythmogenic right ventricular cardiomyopathy; Risk factors; Sudden death

Indexed keywords

ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GENETIC MARKER;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOSOMAL MUTATION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; FEMALE; GENE MUTATION; GENOTYPE; HEART DEPOLARIZATION; HEART LEFT VENTRICLE FAILURE; HEART REPOLARIZATION; HEART RIGHT VENTRICLE DYSPLASIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; MALE; PACEMAKER IMPLANTATION; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK ASSESSMENT; SUDDEN CARDIAC DEATH; ADOLESCENT; AGED; AMBULATORY ELECTROCARDIOGRAPHY; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; DEATH, SUDDEN, CARDIAC; DISEASE FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; GENETIC ASSOCIATION STUDY; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GREECE; HEART LEFT VENTRICLE FUNCTION; HEREDITY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; MUTATION; ODDS RATIO; PATHOPHYSIOLOGY; PEDIGREE; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SEX DIFFERENCE; STATISTICAL MODEL; TACHYCARDIA, VENTRICULAR; TIME FACTOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DEATH, SUDDEN, CARDIAC; DISEASE-FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GREECE; HEREDITY; HUMANS; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; ODDS RATIO; PEDIGREE; PHENOTYPE; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; TACHYCARDIA, VENTRICULAR; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; YOUNG ADULT;

EID: 84975728196     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/euv061     Document Type: Article

References (23)

1. Marcus FI, FontaineGH, Guiraudon G, Frank R, Laurenceau JL, MalergueCet al. Right ventricular dysplasia: A report of 24 adult cases. Circulation 1982;65:384-98
2. Thiene G, Nava A, Corrado D, Rossi L, Pennelli N. Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med 1988;318:129-33
3. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H et al. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace 2011;13:1077-109
4. Quarta G, Muir A, Pantazis A, Syrris P, Gehmlich K, Garcia-Pavia P et al. Familial evaluation in arrhythmogenic right ventricular cardiomyopathy: impact of genetics and revised task force criteria. Circulation 2011;123:2701-9
5. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, BluemkeDAet al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J 2010;31:806-14
6. Protonotarios N, Anastasakis A, Antoniades L, Chlouverakis G, Syrris P, Basso C et al. Arrhythmogenic right ventricular cardiomyopathy/dysplasia on the basis of the revised diagnostic criteria in affected families with desmosomal mutations. Eur Heart J 2011;32:1097-104
7. Turrini P, Corrado D, Basso C, Nava A, Bauce B, Thiene G. Dispersion of ventricular depolarization-repolarization: A noninvasive marker for risk stratification in arrhythmogenic right ventricular cardiomyopathy. Circulation 2001;103:3075-80
8. Corrado D, Leoni L, Link MS, Della Bella P, Gaita F, Curnis A et al. Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation 2003;108: 3084-91
9. Wichter T, Paul M,Wollmann C, Acil T, Gerdes P, AshrafOet al. Implantable cardioverter/ defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: single-center experience of long-term follow-up and complications in 60 patients. Circulation 2004;109:1503-8
10. Hulot JS, Jouven X, Empana JP, Frank R, Fontaine G. Natural history and risk stratification of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circulation 2004;110:1879-84
11. Pinamonti B, Dragos AM, Pyxaras SA, Merlo M, Pivetta A, BarbatiG et al. Prognostic predictors in arrhythmogenic right ventricular cardiomyopathy: results from a 10-year registry. Eur Heart J 2011;32:1105-13
12. Corrado D, Calkins H, Link MS, Leoni L, Favale S, Bevilacqua M et al. Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy/ dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia. Circulation 2010;122:1144-52
13. Bhonsale A, James CA, Tichnell C, Murray B, Gagarin D, Philips B et al. Incidence and predictors of implantable cardioverter-defibrillator therapy in patientswith arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverterdefibrillator implantation for primary prevention. J Am Coll Cardiol 2011;58:1485-96
14. Sawant AC, Bhonsale A, Te Riele AS, Tichnell C, Murray B, Russell SD et al. Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations. J Am Heart Assoc 2014;3: doi: 10.1161/JAHA.114.001471
15. James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H et al. Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 2013;62:1290-7
16. te Riele AS, James CA, Bhonsale A, Groeneweg JA, Camm CF, Murray B et al. Malignant arrhythmogenic right ventricular dysplasia/cardiomyopathy with a normal 12-lead electrocardiogram: A rare but underrecognized clinical entity. Heart Rhythm 2013;10:1484-91
17. Bhonsale A, James CA, Tichnell C, Murray B, Madhavan S, Philips B et al. Risk stratification in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. Circ Arrhythm Electrophysiol 2013;6:569-78
18. Zorzi A, Migliore F, Elmaghawry M, Silvano M, Marra MP, Niero A et al. Electrocardiographic predictors of electroanatomic scar size in arrhythmogenic right ventricular cardiomyopathy: implications for arrhythmic risk stratification. J Cardiovasc Electrophysiol 2013;24:1321-7
19. Protonotarios A, Patrianakos A, Spanoudaki E, Kochiadakis G, Michalodimitrakis E, Vardas P. Left dominant arrhythmogenic cardiomyopathy: A morbid association of ventricular arrhythmias and unexplained infero-lateral T-wave inversion. J Electrocardiol 2013;46:352-5
20. Sen-Chowdhry S, Syrris P, Prasad SK, Hughes SE, Merrifield R, Ward D et al. Leftdominant arrhythmogenic cardiomyopathy: An under-recognized clinical entity. J Am Coll Cardiol 2008;52:2175-87
21. te Riele AS, Bhonsale A, James CA, Rastegar N, Murray B, Burt JR et al. Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratification of arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 2013;62:1761-9
22. Migliore F, Zorzi A, Silvano M, Bevilacqua M, Leoni L, MarraMPet al. Prognostic value of endocardial voltage mapping in patients with arrhythmogenic right ventricular cardiomyopathy/ dysplasia. Circ Arrhyth Electrophysiol 2013;6:167-76
23. Rigato I, Bauce B, Rampazzo A, Zorzi A, Pilichou K, Mazzotti E et al. Compound and digenic heterozygosity predicts lifetime arrhythmic outcome and sudden cardiac death in desmosomal gene-related arrhythmogenic right ventricular cardiomyopathy. Circ Cardiovasc Genet 2013;6:533-42.