A rapid method for the separation of vitamin D and its metabolites by ultra-high performance supercritical fluid chromatography-mass spectrometry

Journal of Chromatography A

Volumn 1440, Issue , 2016, Pages 191-200

  Jumaah, Firas ^a   Larsson, Sara ^b   Essén, Sofia ^a   Cunico, Larissa P ^a   Holm, Cecilia ^b   Turner, Charlotta ^a   Sandahl, Margareta ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Mass spectrometry; Method development; Orthogonal column screening; Plasma; Ultra high performance supercritical fluid chromatography; Vitamin D2 and D3 metabolites

Indexed keywords

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BIOMOLECULES; COLUMN CHROMATOGRAPHY; EFFLUENT TREATMENT; ELECTROSPRAY IONIZATION; GAS CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; METABOLITES; PLASMAS; SPECTROMETRY; SUPERCRITICAL FLUIDS; UNSATURATED COMPOUNDS; VITAMINS;

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; COEFFICIENT OF DETERMINATION; ELECTROSPRAY IONIZATION (ESI); METHOD DEVELOPMENT; PHYSIO-CHEMICAL PROPERTIES; SUPER CRITICAL FLUID CHROMATOGRAPHY; ULTRA HIGH PERFORMANCE; VITAMIN-D;

CHROMATOGRAPHY;

1 AMINOANTHRACENE; 1 HYDROXYVITAMIN D2; 1,25 DIHYDROXYERGOCALCIFEROL; 25 HYDROXYERGOCALCIFEROL; ALFACALCIDOL; AMMONIUM FORMATE; ANTHRACENE DERIVATIVE; CALCIFEDIOL; CALCITRIOL; COLECALCIFEROL; ERGOCALCIFEROL; FORMIC ACID; METHANOL; SECALCIFEROL; TACALCITOL; UNCLASSIFIED DRUG; VITAMIN D; DIHYDROXY-VITAMIN D3;

ARTICLE; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; BACKPRESSURE; CHEMICAL STRUCTURE; COLUMN TEMPERATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION; ELECTROSPRAY; ELUTION; FLOW RATE; HUMAN; INTERMETHOD COMPARISON; IONIZATION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MASS SPECTROMETRY; MEASUREMENT PRECISION; MEASUREMENT REPEATABILITY; METABOLITE; PRESSURE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE; ULTRA HIGH PEFORMANCE SUPERCRITICAL FLUID CHROMATOGRAPHY; VISCOSITY; VITAMIN BLOOD LEVEL; ANALOGS AND DERIVATIVES; BLOOD; BLOOD ANALYSIS; CALIBRATION; METABOLISM; PROCEDURES; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

BLOOD CHEMICAL ANALYSIS; CALCIFEDIOL; CALIBRATION; CHOLECALCIFEROL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; HUMANS; LIMIT OF DETECTION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; VITAMIN D;

EID: 84975678710     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2016.02.043     Document Type: Article

References (30)

1. DeLuca H.F. Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 2004, 80:1689S-1696S.
2. Holick M.F. Vitamin D status: measurement, interpretation, and clinical application. Ann. Epidemiol. 2009, 19:73-78.
3. Ohyama Y., Yamasaki T. Eight cytochrome P450s catalyze vitamin D metabolism. Front. Biosci. 2004, 9:3007-3018.
4. Ali S.L. Determination of vitamin-D3 in cod-liver oil (Lebertran) by high-pressure liquid-chromatography. Fresen. Z Anal. Chem. 1978, 293:131-134.
5. Byrdwell W.C., DeVries J., Exler J., Harnly J.M., Holden J.M., Holick M.F., Hollis B.W., Horst R.L., Lada M., Lemar L.E., Patterson K.Y., Philips K.M., Tarrago-Trani M.T., Wolf W.R. Analyzing vitamin D in foods and supplements: methodologic challenges. Am. J. Clin. Nutr. 2008, 88:554S-557S.
6. Staffas A., Nyman A. Determination of cholecalciferol (vitamin D3) in selected foods by liquid chromatography: NMKL collaborative study. J. AOAC Int. 2003, 86:400-406.
7. Barger-Lux M.J., Heaney R.P., Dowell S., Chen T.C., Holick M.F. Vitamin D and its major metabolites: Serum levels after graded oral dosing in healthy men. Osteopor. Int. 1998, 8:222-230.
8. Mena-Bravo A., Ferreiro-Vera C., Priego-Capote F., Maestro M.A., Mourino A., Quesada-Gomez J.M., de Castro M.D.L. Quantitative analytical method to evaluate the metabolism of vitamin D. Clin. Chim. Acta 2015, 442:6-12.
9. Malmberg P., Karlsson T., Svensson H., Lonn M., Carlsson N.G., Sandberg A.S., Jennische E., Osmancevic A., Holmang A. A new approach to measuring vitamin D in human adipose tissue using time-of-flight secondary ion mass spectrometry: a pilot study. J. Photochem. Photobiol. B 2014, 138:295-301.
10. Babic N. Analytical methods and performance of the immunoassay methods for determination of vitamin D in comparison to mass spectrometry. J. Med. Biochem. 2012, 31:333-338.
11. Byrdwell W.C. Comparison of analysis of vitamin D-3 in foods using ultraviolet and mass spectrometric detection. J. Agr. Food Chem. 2009, 57:2135-2146.
12. El-Khoury J.M., Reineks E.Z., Wang S.H. Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues. Clin. Biochem. 2011, 44:66-76.
13. Haddad J.G. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J. Clin. Endocr. Metab. 1971, 33:992-
14. Lind C., Chen J., Byrjalsen I. Enzyme immunoassay for measuring 25-hydroxyvitamin D3 in serum. Clin. Chem. 1997, 43:943-949.
15. Hollis B.W., Napoli J.L. Improved radioimmunoassay for vitamin-D and its use in assessing vitamin-D status. Clin. Chem. 1985, 31:1815-1819.
16. Zerwekh J.E. Blood biomarkers of vitamin D status. Am. J. Clin. Nutr. 2008, 87:1087S-1091S.
17. Volmer D.A., Mendes L.R.B.C., Stokes C.S. Analysis of vitamin D metabolic markers by mass spectrometry: current techniques, limitations of the gold standard method, and anticipated future directions. Mass Spectrom. Rev. 2015, 34:2-23.
18. Gathungu R.M., Flarakos C.C., Reddy G.S., Vouros P. The role of mass spectrometry in the analysis of vitamin D compounds. Mass Spectrom. Rev. 2013, 32:72-86.
19. Smith R.M. Supercritical fluids in separation science-the dreams, the reality and the future. J. Chromatogr. A 1999, 856:83-115.
20. Lesellier E., Mith D., Dubrulle I. Method developments approaches in supercritical fluid chromatography applied to the analysis of cosmetics. J. Chromatogr. A 2015, 1423:158-168.
21. Grand-Guillaume Perrenoud A., Veuthey J.L., Guillarme D. Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for the analysis of pharmaceutical compounds. J. Chromatogr. A 2012, 1266:158-167.
22. Yu Yang S.B.H., Miller David J. Estimating flow-rates for sub- and supercritical fluid extractions with linear restrictors. J. Chromatogr. A 1995, 690:131-139.
23. Ding S.J., Schoenmakers I., Jones K., Koulman A., Prentice A., Volmer D.A. Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS/MS. Anal. Bioanal. Chem. 2010, 398:779-789.
24. Soave G. Equilibrium constants from a modified Redlich-Kwong equation of state. Chem. Eng. Sci. 1972, 27:1197.
25. Peneloux A., Rauzy E., Freze R. A consistent correction for Redlich-Kwong-Soave volumes. Fluid Phase Equilibr. 1982, 8:7-23.
26. Pfohl O., Petkov S., Brunner G. PE 2000: A Powerful Tool to Correlate Phase Equilibrium 2000, Herbert UtzVerlag Wissenschaft, München.
27. NIST Standard Reference Data, Thermophysical Properties of Fluid Systems. , 2015 (accessed 04.12.15). http://webbook.nist.gov/chemistry/fluid/.
28. Bouigeon C., Thiebaut D., Caude M. Long packed column supercritical fluid chromatography: influence of pressure drop on apparent efficiency. Anal. Chem. 1996, 68:3622-3630.
29. de Hoffmann E., Stroobant V. Mass Spectrometry: Principles and Applications 2007, John Wiley & Sons Ltd., Chichester. third ed.
30. Shepard R.M., Horst R.L., Hamstra A.J., Deluca H.F. Determination of vitamin-D and its metabolites in plasma from normal and anephric man. Biochem. J. 1979, 182:55-69.