Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?

Circulation Research

Volumn 118, Issue 7, 2016, Pages 1143-1150

  Harper, Shavonn C ^a   Brack, Andrew ^b   Macdonnell, Scott ^c,d   Franti, Michael ^c,d   Olwin, Bradley B ^e   Bailey, Beth A ^f   Rudnicki, Michael A ^g,h   Houser, Steven R ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Cardiovascular Research ^*  (United States)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f URSINUS COLLEGE   (United States)

^g OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^h UNIVERSITY OF OTTAWA   (Canada)

Author keywords

aging; growth factors; myocardium; myokines; pathological hypertrophy

Indexed keywords

GROWTH DIFFERENTIATION FACTOR; GROWTH DIFFERENTIATION FACTOR 11; MYOSTATIN; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; GDF11 PROTEIN, HUMAN; GDF11 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN;

AGE; AGED; AGING; ARTICLE; BIOCHEMICAL COMPOSITION; CARDIAC MUSCLE; CARDIOVASCULAR EFFECT; DISEASES; DRUG EFFICACY; HUMAN; MUSCLE DISEASE; MUSCLE INJURY; NONHUMAN; PRIORITY JOURNAL; SATELLITE CELL CULTURE; SKELETAL MUSCLE; TARGET TISSUE; ANIMAL; ANIMAL MODEL; BLOOD; C57BL MOUSE; CACHEXIA; CELL CULTURE; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; HEART; HYPERTROPHY; INJURIES; MUSCLE; MUSCULAR DISEASES; PARABIOSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; REGENERATION; REPRODUCIBILITY; SIGNAL TRANSDUCTION; SINGLE BLIND PROCEDURE;

AGING; ANIMALS; BONE MORPHOGENETIC PROTEINS; CACHEXIA; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GROWTH DIFFERENTIATION FACTORS; HEART; HUMANS; HYPERTROPHY; MICE, INBRED C57BL; MODELS, ANIMAL; MUSCLE, SKELETAL; MUSCLES; MUSCULAR DISEASES; MYOCARDIUM; MYOSTATIN; PARABIOSIS; RECOMBINANT PROTEINS; REGENERATION; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SINGLE-BLIND METHOD; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 84975476185     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.307962     Document Type: Article

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