Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

Cell Death and Disease

Volumn 6, Issue 10, 2015, Pages

  Bertrand, T ^a   Lesept, F ^a   Chevilley, A ^a   Lenoir, S ^a   Aimable, M ^a   Briens, A ^a   Hommet, Y ^a   Bardou, I ^a   Parcq, J ^a   Vivien, D ^a  

^a UNIVERSITÉ DE CAEN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; APROTININ; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOTYROSINE; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; EGFR PROTEIN, HUMAN; PLAT PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM TRANSPORT; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; EXCITOTOXICITY; FIBRINOLYSIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; VIDEO MICROSCOPY; CALCIUM SIGNALING; CHEMISTRY; FEMALE; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CALCIUM SIGNALING; CELL SURVIVAL; FEMALE; HUMANS; PROTEIN CONFORMATION; RECEPTOR CROSS-TALK; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84975247150     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.296     Document Type: Article

References (32)

1. Thorsen S, Glas-Greenwalt P, Astrup T. Differences in the binding to fibrin of urokinase and tissue plasminogen activator. Thromb Diath Haemorrh 1972; 28: 65-74.
2. Polavarapu R, Gongora MC, Yi H, Ranganthan S, Lawrence D a, Strickland D et al. Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood 2007; 109: 3270-3278.
3. Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 1997; 17: 543-552.
4. Shin CY, Kundel M, Wells DG. Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation. J Neurosci 2004; 24: 9425-9433.
5. Gorter JA, Van Vliet EA, Rauwerda H, Breit T, Stad R, van Schaik L et al. Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat. Epilepsia 2007; 48: 53-64.
6. Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T. Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins. FEBS Lett 2005; 579: 6879-6884.
7. Rijken DC, Hoylaerts M, Collen D. Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator. J Biol Chem 1982; 257: 2920-2925.
8. Baranes D, Lederfein D, Huang Y, Chen M, Bailey CH, Kandel ER. Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron 1998; 21: 813-825.
9. Liot G, Roussel BD, Lebeurrier N, Benchenane K, López-Atalaya JP, Vivien D et al. Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity. J Neurochem 2006; 98: 1458-1464.
10. Lee H-Y, Hwang I-Y, Im H, Koh J-Y, Kim Y-H. Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons. J Neurochem 2007; 101: 1236-1247.
11. Pittman RN, Ivins JK, Buettner HM. Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth. J Neurosci 1989; 9: 4269-4286.
12. Seeds NW, Basham ME, Haffke SP. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene. Proc Nat. Acad Sci USA 1999; 96: 14118-14123.
13. Kim Y. Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator. Science 1999; 284: 647-650.
14. Henry VJ, Lecointre M, Laudenbach V, Ali C, Macrez R, Jullienne A et al. High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate. Neurobiol Dis 2013; 50: 201-208.
15. Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 2001; 7: 59-64.
16. Wang Y, Tsirka S, Strickland S, Stieg P, Soriano S, Lipton S. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 1998; 4: 228-231.
17. Samson AL, Nevin ST, Croucher D, Niego B, Daniel PB, Weiss TW et al. Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. J Neurochem 2008; 107: 1091-1101.
18. Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM et al. Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptordependent signaling and neurotoxicity. Cell Death Differ 2012; 19: 1983-1991.
19. Wu F, Echeverry R, Wu J, An J, Haile WB, Cooper DS et al. Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway. Mol Cell Neurosci 2013; 52: 9-19.
20. Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M et al. Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain. J Neurosci 2012; 32: 9848-9858.
21. Haile WB, Wu J, Echeverry R, Wu F, An J, Yepes M. Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α. J Cereb Blood Flow Metab 2012; 32: 57-69.
22. Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P et al. Tissue plasminogen activator prevents white matter damage following stroke. J Exp Med 2011; 208: 1229-18.
23. Macrez R, Obiang P, Gauberti M, Roussel B, Baron A, Parcq J et al. Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis. Stroke 2011; 42: 2315-2322.
24. Liot G, Benchenane K, Léveillé F, López-Atalaya JP, Fernández-Monreal M, Ruocco A et al. 2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo. J Cereb Blood Flow Metab 2004; 24: 1153-1159.
25. Baron A, Montagne A, Cassé F, Launay S, Maubert E, Ali C et al. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ 2010; 17: 860-871.
26. Rijken DC, Collen D. Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture. J Biol Chem 1981; 256: 7035-7041.
27. Wallén P, Pohl G, Bergsdorf N, Rånby M, Ny T, Jörnvall H. Purification and characterization of a melanoma cell plasminogen activator. Eur J Biochem 1983; 132: 681-686.
28. Reddrop C, Moldrich RX, Beart PM, Farso M, Liberatore GT, Howells DW et al. Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activatorinduced potentiation of excitotoxic injury. Stroke 2005; 36: 1241-1246.
29. Mantuano E, Lam MS, Gonias SL. LRP1 assembles unique co-receptor systems to initiate cell-signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem 2013; 288: 34009-34018.
30. Fleury V, Angles-Cano E. Characterization of the binding of plasminogen to fibrin surfaces: the role of carboxy-terminal lysines. Biochemistry 1991; 30: 7630-7638.
31. Nicole O, Ali C, Docagne F, Plawinski L, MacKenzie ET, Vivien D et al. Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway. J Neurosci 2001; 21: 3024-3033.
32. Koh JY, Gwag BJ, Lobner D, Choi DW. Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 1995; 268: 573-575.