Mucking around in the genome: MUC5B in idiopathic pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 193, Issue 4, 2016, Pages 355-357

  Kolb, Martin ^a,b   White, Eric S ^c   Gauldie, Jack ^b,d  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN 5B;

ALLELE; DISEASE COURSE; EDITORIAL; ENDOPLASMIC RETICULUM STRESS; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM CELL; MACROPHAGE FUNCTION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; FEMALE; GENETICS; MALE; PROMOTER REGION;

FEMALE; GENE EXPRESSION; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MALE; MUCIN-5B; PROMOTER REGIONS, GENETIC;

EID: 84975230722     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201512-2360ED     Document Type: Editorial

References (14)

1. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 2011;364:1503-1512.
2. Conti C, Montero-Fernandez A, Borg E, Osadolor T, Viola P, De Lauretis A, Stock CJ, Bonifazi M, Bonini M, Caramori G, et al. Mucins MUC5B and MUC5AC in distal airways and honeycomb spaces: comparison between idiopathic pulmonary fibrosis/usual interstitial pneumonia, fibrotic nonspecific interstitial pneumonitis, and control lungs. Am J Respir Crit Care Med 2016;193:462-464.
3. Nakano Y, Yang IV, Walts AD, Watson AM, Helling BA, Fletcher AA, Lara AR, Schwarz MI, Evans CM, Schwartz DA. MUC5B promoter variant rs35705950 affects MUC5B expression in the distal airways in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2016;193: 464-466.
4. Marian AJ. Challenges in medical applications of whole exome/ genome sequencing discoveries. Trends Cardiovasc Med 2012;22: 219-223.
5. Renzoni E, Srihari V, Sestini P. Pathogenesis of idiopathic pulmonary fibrosis: review of recent findings. F1000Prime Rep 2014;6:69.
6. Peljto AL, Zhang Y, Fingerlin TE, Ma SF, Garcia JG, Richards TJ, Silveira LJ, Lindell KO, Steele MP, Loyd JE, et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA 2013;309: 2232-2239.
7. Scholand MB, Wolff R, Crossno PF, Sundar K, Winegar M, Whipple S, Carey P, Sunchild N, Coon H. Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype. Cough 2014;10:3.
8. Morris A, Gibson K, Collman RG. The lung microbiome in idiopathic pulmonary fibrosis: what does it mean and what should we do about it? Am J Respir Crit Care Med 2014;190:850-852.
9. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, et al. Muc5b is required for airway defence. Nature 2014;505:412-416.
10. Todd NW, Atamas SP, Luzina IG, Galvin JR. Permanent alveolar collapse is the predominant mechanism in idiopathic pulmonary fibrosis. Expert Rev Respir Med 2015;9:411-418.
11. Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, Günther A, Klepetko W, Bates JH, Smith B, Geiser T, et al. Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis. Am J Respir Cell Mol Biol 2015;52: 232-243.
12. Liptzin DR, Watson AM, Murphy E, Kroehl ME, Dishop MK, Galambos C, Evans CM, Schwarz MI, Deterding RR, Schwartz DA. MUC5B expression and location in surfactant protein C mutations in children. Pediatr Pulmonol 2015;50: 1270-1276.
13. Plantier L, Crestani B, Wert SE, Dehoux M, Zweytick B, Guenther A, Whitsett JA. Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. Thorax 2011;66:651-657.
14. Kropski JA, Lawson WE, Young LR, Blackwell TS. Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech 2013;6:9-17.