Mucins MUC5B and MUC5AC in distal airways and honeycomb spaces: Comparison among idiopathic pulmonary fibrosis/usual interstitial pneumonia, fibrotic nonspecific interstitial pneumonitis, and control lungs

American Journal of Respiratory and Critical Care Medicine

Volumn 193, Issue 4, 2016, Pages 462-464

  Conti, Caterina ^a,b   Montero Fernandez, Angeles ^c   Borg, Elaine ^d   Osadolor, Tina ^a   Viola, Patrizia ^a   De Lauretis, Angelo ^a   Stock, Carmel J ^a   Bonifazi, Martina ^a   Bonini, Matteo ^a   Caramori, Gaetano ^e   Lindahl, Gisela ^a   Blasi, Francesco B ^b   Nicholson, Andrew G ^c   Wells, Athol U ^a   Sestini, Piersante ^f   Renzoni, Elisabetta ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^e UNIVERSITY OF FERRARA   (Italy)

^f UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; MUCIN 5AC; MUCIN 5B; MUC5AC PROTEIN, HUMAN; MUC5B PROTEIN, HUMAN;

ADULT; ANTIGEN ANTIBODY REACTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; IDIOPATHIC DISEASE; IDIOPATHIC NONSPECIFIC INTERSTITIAL PNEUMONITIS; IMMUNOFLUORESCENCE; INTERSTITIAL PNEUMONIA; LETTER; LUNG BIOPSY; LUNG CAPACITY; LUNG PARENCHYMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATION CONTROL; SMOKING; SYSTEMIC SCLEROSIS; SYSTEMIC SCLEROSIS ASSOCIATED NONSPECIFIC INTERSTITIAL PNEUMONITIS; AGED; BIOPSY; GENE EXPRESSION; GENETICS; INTERSTITIAL LUNG DISEASE; LUNG; MIDDLE AGED; PATHOLOGY;

AGED; BIOPSY; FEMALE; GENE EXPRESSION; HUMANS; IDIOPATHIC INTERSTITIAL PNEUMONIAS; IDIOPATHIC PULMONARY FIBROSIS; LUNG; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; MUCIN 5AC; MUCIN-5B;

EID: 84975125157     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201507-1322LE     Document Type: Letter

References (16)

1. Renzoni E, Srihari V, Sestini P. Pathogenesis of idiopathic pulmonary fibrosis: review of recent findings. F1000Prime Rep 2014;6:69.
2. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 2011;364:1503-1512.
3. Wang C, Zhuang Y, Guo W, Cao L, Zhang H, Xu L, Fan Y, Zhang D, Wang Y. Mucin 5B promoter polymorphism is associated with susceptibility to interstitial lung diseases in Chinese males. PLoS One 2014;9:e104919.
4. Zhang GY, Liao T, Gao WY. MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 2011;365:178.
5. Peljto AL, Selman M, Kim DS, Murphy E, Tucker L, Pardo A, Lee JS, Ji W, Schwarz MI, Yang IV, et al. The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries. Chest 2015;147: 460-464.
6. Borie R, Crestani B, Dieude P, Nunes H, Allanore Y, Kannengiesser C, Airo P, Matucci-Cerinic M, Wallaert B, Israel-Biet D, et al. The MUC5B variant is associated with idiopathic pulmonary fibrosis but not with systemic sclerosis interstitial lung disease in the European Caucasian population. PLoS One 2013;8: e70621.
7. Horimasu Y, Ohshimo S, Bonella F, Tanaka S, Ishikawa N, Hattori N, Kohno N, Guzman J, Costabel U. MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis. Respirology 2015;20:439-444.
8. Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, Broderick SM, Wade MS, Hysi P, Scuirba J, et al. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med 2013;1: 309-317.
9. Wei R, Li C, Zhang M, Jones-Hall YL, Myers JL, Noth I, Liu W. Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes. Transl Res 2014;163: 494-502.
10. Stock CJ, Sato H, Fonseca C, Banya WA, Molyneaux PL, Adamali H, Russell AM, Denton CP, Abraham DJ, Hansell DM, et al. Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis. Thorax 2013;68: 436-441.
11. Peljto AL, Zhang Y, Fingerlin TE, Ma SF, Garcia JGN, Richards TJ, Silveira LJ, Lindell KO, Steele MP, Loyd JE, et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA 2013;309: 2232-2239.
12. Seibold MA, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS One 2013;8: e58658.
13. Plantier L, Crestani B, Wert SE, Dehoux M, Zweytick B, Guenther A, Whitsett JA. Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. Thorax 2011;66:651-657.
14. Conti C, Montero-Fernandez A, Nicholson AG, Osadolor T, Blasi F, De Lauretis A, Wells AU, Sestini P, Renzoni E. Distribution of mucins MUC5B and MUC5AC in distal airways and honeycomb spaces: a comparison between UIP and other ILD patterns [abstract]. Am J Respir Crit Care Med 2015;191: A2161.
15. Wells AU, Desai SR, Rubens MB, Goh NS, Cramer D, Nicholson AG, Colby TV, du Bois RM, Hansell DM. Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography. Am J Respir Crit Care Med 2003;167: 962-969.
16. Nakano Y, Evans CM, Yang IV, Schwarz MI, Schwartz DA. MUC5B promoter variant rs35705950 affects MUC5B expression and this effect is localized to the distal airways in IPF [abstract]. Am J Respir Crit Care Med 2015;191:A3446.