The Syrian conflict and infectious diseases

Expert Review of Anti-Infective Therapy

Volumn 14, Issue 6, 2016, Pages 547-555

  Ozaras, Resat ^a   Leblebicioglu, Hakan ^b   Sunbul, Mustafa ^b   Tabak, Fehmi ^a   Balkan, Ilker Inanc ^a   Yemisen, Mucahit ^a   Sencan, Irfan ^c,d   Ozturk, Recep ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^c SAKARYA UNIVERSITY   (Turkey)

^d MINISTRY OF HEALTH   (Turkey)

Author keywords

infectious diseases; Refugee health; Syria

Indexed keywords

CHOLERA; CONFLICT; DISEASE RE-EMERGENCE; EGYPT; EPIDEMIC; HEALTH CARE; HEALTH CARE FACILITY; HEALTH CARE PERSONNEL; HEALTH CARE POLICY; HUMAN; INFECTION; IRAQ; JORDAN; LEBANON; MEASLES; MEDICAL STAFF; MIGRATION; POLIOMYELITIS; REFUGEE; REFUGEE CAMP; REVIEW; SANITATION; SCREENING TEST; SKIN LEISHMANIASIS; SYRIAN ARAB REPUBLIC; TUBERCULOSIS; TURKEY (REPUBLIC); ADVERSE EFFECTS; AFRICA; COMMUNICABLE DISEASES, EMERGING; ETHNOLOGY; EUROPE; HEALTH SERVICE; INCIDENCE; MIDDLE EAST; STATISTICS AND NUMERICAL DATA; SUPPLY AND DISTRIBUTION; TRENDS; WAR EXPOSURE;

AFRICA, NORTHERN; COMMUNICABLE DISEASES, EMERGING; EUROPE; HEALTH SERVICES; HUMANS; INCIDENCE; MIDDLE EAST; REFUGEES; SYRIA; WAR EXPOSURE;

EID: 84975223718     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1080/14787210.2016.1177457     Document Type: Review

References (70)

1. S.Hargreaves Europe’s migrants face unacceptable humanitarian situation. Lancet Infect Dis. 2016;16:27–28.
2. World Health Organization. Donor update Syrian Arab Republic-Quarter 3 report [cited 2016 Feb26]. Available from: http://www.who.int/hac/syria_donorupdate_18102013.pdf?ua=1
3. World Bank world development indicators. 2012 [cited 2016 Feb26]. Available from: http://data.worldbank.org/sites/default/files/wdi-2012-ebook.pdf
4. United Nations Population Division. World Population Prospects The 2010 Revision Volume II: Demographic Profiles. [cited 2016 Feb26]. Available from: http://www.un.org/en/development/desa/population/publications/pdf/trends/WPP2010/WPP2010_Volume-II_Demographic-Profiles.pdf
5. World Health Organization. Syrian Arab Republic: NCD country profile. [cited 2016 Feb26]. Available from: http://www.who.int/gho/countries/syr.pdf?ua=1
6. Z.B.Taleb, R.Bahelah, F.M.Fouad, et al. Syria: health in a country undergoing tragic transition. Int J Public Health. 2015;60(suppl 1):63–72.• This review shows that the health-care figures in Syria before the conflict are improving.
7. United Nations data, country profile, Syrian Arab Republic. [cited 2016 Feb26]. Available from: http://data.un.org/CountryProfile.aspx?crName=Syrian%20Arab%20Republic
8. World Health Organization. Health in Syrian Arab Republic 2013. [cited 2016 Feb26]. Available from: http://www.who.int/hac/syria_dashboard_6june2013_final_small_.pdf
9. Save the Children. A devastating toll. The impact of three years of war on the health of Syria’s children; 2014 [cited 2016 Feb26]. Available from: http://reliefweb.int/sites/reliefweb.int/files/resources/SAVE_THE_CHILDREN_A_DEVASTATING_TOLL.PDF
10. The UN Refugee Agency, Syria regional refugee response. [cited 2016 Feb26]. http://data.unhcr.org/syrianrefugees/regional.php•• This website of United Nations provides up-to-date information and statistics about Syrian refugees.
11. W.Kimbrough, V.Saliba, M.Dahab, et al. The burden of tuberculosis in crisis-affected populations: a systematic review. Lancet Infect Dis. 2012;12:950–965.
12. S.T.Cookson, H.Abaza, K.R.Clarke, et al. Impact of and response to increased tuberculosis prevalence among Syrian refugees compared with Jordanian tuberculosis prevalence: case study of a tuberculosis public health strategy. Conflict Health. 2015;9:18.
13. J.H.van Loenhout-Rooyackers. Risk of tuberculosis in the inadequate handling of refugees seeking asylum. Ned Tijdschr Geneeskd. 1994;138(50):2496–2500.
14. J.C.Murray, K.F.Ortblad, C.Guinovart, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):1005–1070.
15. World Health Organisation. Global tuberculosis report; 2015 [cited 2016 Feb26]. Available from: http://www.who.int/tb/publications/global_report/en/
16. F.P.Mockenhaupt, K.A.Barbre, M.Jensenius, et al. Profile of illness in Syrian refugees: A GeoSentinel analysis, 2013 to 2015. Euro Surveill. 2016 Mar 10;21(10):1–5.
17. Lebanon Millennium Development Goals Report 2013–2014. [cited 2016 Feb26]. Available from: http://planipolis.iiep.unesco.org/upload/Lebanon/Lebanon_MDG_2013-2014.pdf
18. M.A.McDowell, S.Rafati, M.Ramalho-Ortigao, et al. Leishmaniasis: middle East and North Africa research and development priorities. PLoS Negl Trop Dis. 2011;5:e1219.
19. World Health Organization. Leishmaniasis: diagnosis, detection and surveillance. Geneva: WHO; 2013. [cited 2016 Feb26]. Available from:: http://www.who.int/leishmaniasis/surveillance/en/
20. Weekly Epidemiological Bulletin 2014, Syrian Ministry of Health. [cited 2016 Feb26, Available from: http://www.moh.gov.sy
21. K.Hayani, A.Dandashli, E.Weisshaar. Cutaneous leishmaniasis in Syria: clinical features, current status and the effects of war. Acta Derm Venereol. 2015;95(1):62–66.• A comprehensive paper describing epidemiological and clinical features of cutaneous leishmaniasis in Syria.
22. H.Leblebicioglu, R.Ozaras. The Syrian conflict and infectious disease challenges. Travel Med Infect Dis. 2015;13(6):443–444.
23. A.J.Magill, M.Grogl, R.A.GasserJr, et al. Visceral infection caused by Leishmania tropica in veterans of operation desert storm. N Engl J Med. 1993;328:1383–1387.
24. D.P.Eiras, L.A.Kirkman, H.W.Murray. Cutaneous leishmaniasis: current treatment practices in the USA for returning travelers. Curr Treat Options Infect Dis. 2015;7(1):52–62.
25. M.S.Gurel, Y.Yesilova, M.K.Olgen, et al. Cutaneous leishmaniasis in Turkey. Turkiye Parazitol Derg. 2012;36:121–129.
26. Data provided by Republic of Turkey Ministry of Health, Turkish Public Health Association. Available from: http://www.thsk.gov.tr/en/
27. A.Alawieh, U.Musharrafieh, A.Jaber, et al. Revisiting leishmaniasis in the time of war: the Syrian conflict and the Lebanese outbreak. Int J Infect Dis. 2014;29:115–119.
28. M.Saroufim, K.Charafeddine, G.Issa, et al. Ongoing epidemic of cutaneous leishmaniasis among Syrian refugees, Lebanon. Emerg Infect Dis. 2014;20:1712–1715.
29. Leishmania-Lebanon Republic of Lebanon Ministry of Public Health. [cited 2016 Feb26]. Available from: www.moph.gov.lb.
30. World Health Organization. Situation report, Syrian Arab Republic, Jordan, Lebanon, Iraq. [cited 2016 Feb26]. Available from: http://www.who.int/hac/crises/syr/sitreps/syria_regional_sitrep_5_20june2013.pdf
31. Jordan Ministry of Health, The protocol of dealing with cutaneous leishmaniasis. Jordan: Directorate of Infectious Diseases, Minister of Health. [cited 2016 Feb26]. Available from: http://www.dcd.gov.jo/EIndex.asp?id=900
32. Global Polio Eradication Initiative. Polio this week; 2014 [cited 2016 Feb26.] Available from: http:// polioeradication.org/Dataandmonitoring/Poliothisweek.aspx
33. Z.Sahloul, A.Coutts, F.M.Fouad, et al. Health response system for Syria: beyond official narrative. Lancet. 2014;383(9915):407.• This short report describes the polio outbreak in Syria and the problems in vaccination and the management of the outbreak.
34. World Health Ogranisation. Polio outbreak in the Middle East: update. [cited 2016 Feb26]. Available from: http://www.who.int/csr/don/2014_3_21polio/en
35. Republic of Turkey, Ministry of Health. [cited 2016 Feb26]. Available from: http://www.saglik.gov.tr/TR/belge/1-32053/cocuk-felci-asilama-calismalari-basladi.html
36. UNICEF news note: Measles vaccination campaign aims to immunize over 2.6 million Syrian children. Damascus, Syria; [updated 2015 Apr 24; cited 2016 Feb 26]. Available from: http://www.unicef.org/media/media_81686.html
37. S.Pousins. Syrian crisis: health experts say more can be done. Lancet. 2015;385:931–934.
38. Medecins Sans Frontieres press release. Syria: Measles epidemic signals growing humanitarian needs; [updated 2013 Jun 18; cited 2016 Feb 26]. Available from: http://www.msf.org/article243/syria-measles-epidemic-signals-growing-humanitarian-needs
39. Lebanon Ministry of Public Health. Past years: annual reports. [cited 2016 Feb26]. Available from: http://www.moph.gov.lb/Prevention/Surveillance/Pages/PastYears.aspx
40. World Health Organization, Regional Office for Eastern Mediterranean. Lebanon launches nationwide polio immunization campaign. Beirut; [updated 2014 Apr 10; cited 2016 Feb 26]. Available from: http://www.emro.who.int/media/news/lebanon-polio-campaign.html
41. Jordan Ministry of Health, Communicable Disease System. [cited 2016 Feb26]. Available from: http://www.moh.gov.jo/EN/Pages/mainind.aspx?ind=http%3a//apps.moh.gov.jo/reports/headermain.jsp?firstjsp=epimedsituationmenu&lang_ parameter=english
42. World Health Organization. Iraq health situation reports. [cited 2016 Feb26]. Available from: http://www.who.int/hac/crises/irq/sitreps/iraq_measles_cases_evolution_june2015.pdf
43. G.Jones, S.Haeghebaert, B.Merlin, et al. Measles outbreak in a refugee settlement in Calais, France: January to February 2016. Euro Surveill. 2016 Mar 17;21(11):1–4.
44. World Health Organization, press archive. WHO warns of increased risk of disease epidemics in Syria and in neighbouring countries as summer approaches. [updated 2013 Jun 3; cited 2016 Feb 26]. Available from: http://www.emro.who.int/press-releases/2013/disease-epidemics-syria.html
45. S.L.Sharara, S.S.Kanj War and infectious diseases: challenges of the Syrian civil war. PLoS Pathog. 2014;10:e1004438.•• This review comprehensively discusses the infectious challenges in Syria during the conflict.
46. World Health Organization, news. Ministry of Health, WHO and partners step up response to cholera outbreak in Iraq. Baghdad; [updated 2015 Sep 20; cited 2016 Feb 26]. Available from: http://www.emro.who.int/irq/iraq-news/response-to-cholera-outbreak-stepped-up.html
47. S.Angeletti, G.Ceccarelli, S.Vita, et al. Sanitary Bureau of Asylum Seekers Center of Castelnuovo di Porto. Unusual microorganisms and antimicrobial resistances in a group of Syrian migrants: sentinel surveillance data from an asylum seekers centre in Italy. Travel Med Infect Dis. 2016 Mar 15. doi:10.1016/j.tmaid.2016.03.005. pii: S1477-8939(16)00035-1 [Epub ahead of print]
48. R.Rafei, F.Dabboussi, M.Hamze, et al. First report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war. Int J Infect Dis. 2014;21:21–23.
49. F.Heydari, C.Mammina, F.Koksal. NDM-1-producing Acinetobacter baumannii ST85 now in Turkey, including one isolate from a Syrian refugee. J Med Microbiol. 2015;64(9):1027–1029.
50. A.Lerner, E.Solter, E.Rachi, et al. Detection and characterization of carbapenemase-producing Enterobacteriaceae in wounded Syrian patients admitted to hospitals in northern Israel. Eur J Clin Microbiol Infect Dis. 2016;35(1):149–154.
51. R.Rafei, H.Pailhoriès, M.Hamze, et al. Molecular epidemiology of Acinetobacter baumannii in different hospitals in Tripoli, Lebanon using bla(OXA-51-like) sequence based typing. BMC Microbiol. 2015;16(15):103.
52. World Health Organization, news. WHO hosts advocacy event for Syrian refugees in Cairo. [updated 2015 May 21; cited 2016 Feb 26]. Available from: http://www.emro.who.int/egy/egypt-news/who-hosts-advocacy-event-for-syrian-refugees-in-cairo.html
53. I.A.Aziz, C.V.Hutchinson, J.Maltby. Quality of life of Syrian refugees living in camps in the Kurdistan Region of Iraq. PeerJ. 2014;2:e670.
54. World Health Organization. Update on current cholera outbreak in Iraq, SITREP situation report 18. [updated 2015 Nov 5; cited 2016 Feb 26]. Available from: http://www.emro.who.int/images/stories/SITREP_18EXT_REV.pdf?ua=1
55. World Health Organization, regional situation report, September 2015. WHO response to the Syrian crisis. [cited 2016 Feb26]. Available from: http://www.emro.who.int/images/stories/WHO_SitRep_September2015.pdf
56. United Nations. Regional refugee & resilience plan 2015–2016, regional strategic overview. [cited 2016 Feb26]. Available from: http://www.3rpsyriacrisis.org/wp-content/uploads/2015/01/3RP-Report-Overview.pdf
57. S.E.Parkinson, O.Behrouzan. Negotiating health and life: Syrian refugees and the politics of access in Lebanon. Soc Sci Med. 2015;146:324–331.
58. World Health Organization. Lebanese Epi-Monitor Updates & Reviews. Volume 2, issue 3. [updated 2015 Mar 19; cited 2016 Feb 26]. Available from: http://www.emro.who.int/images/stories/lebanon/NO_2_3_Mumps_March_2015.pdf?ua=1
59. Republic of Turkey, Prime Ministry Disaster & Emergency Management Authority. Disaster Report. [cited 2016 Feb 26]. Available from: https://www.afad.gov.tr/TR/IcerikDetay1.aspx?ID=16&IcerikID=848
60. H.Leblebicioglu. Managing health and infections in refugees: Turkey’s experience. Int J Infect Dis. 2016;45(Supp 1):56.
61. Republic of Turkey, Prime Ministry Disaster & Emergency Management Authority. Syrian Refugees in Turkey, 2013. Field survey results. [cited 2016 Feb26]. Available from: https://www.afad.gov.tr/Dokuman/TR/61-2013123015505-syrian-refugees-in-turkey-2013_print_12.11.2013_eng.pdf
62. The United Nations Refugee Agency. Winterization plan for the refugee crisis in Europe. [updated Nov 2015–Feb 2016; cited 2016 Feb 26]. Available from: http://www.unhcr.org/563b26049.html
63. World Health Organization. Health Topics. [cited 2016 Feb26]. Available from: http://www.euro.who.int/en/health-topics/health-determinants/migration-and-health/migrant-health-in-the-european-region/migration-and-health-key-issues#292115
64. European Centre for Disease Prevention and Control, Communicable disease risks associated with the movement of refugees in Europe during the winter season10 November 2015. [cited 2016 Feb26]. Available from: http://ecdc.europa.eu/en/publications/Publications/refugee-migrant-health-in-european-winter-rapid-risk-assessment.pdf• This report highlights the infectious disease risks in Europe associated with the refugees in winter season and preventive measures.
65. Health Affairs Blog, D.Göpffarth, S.Bauhoff. The Public health dimension of Germany’s refugee crisis. [updated 2015 Oct 22; cited 2016 Feb 26]. Available from: http://healthaffairs.org/blog/2015/10/22/the-public-health-dimension-of-germanys-refugee-crisis/
66. World Health Organization. Frequently asked questions on migration and health. cited 2016 Feb26]. Available from: http://www.who.int/features/qa/88/en/• World Health Organization’s website discussing the questions including screening, vaccination, triage, and care of immigrants and refugees.
67. WHO Migration and Heath: Key Issues. [cited 2016 Feb26]. Available from: http://www.euro.who.int/en/health-topics/health-determinants/migration-and-health/migrant-health-in-the-european-region/migration-and-health-key-issues#292929
68. B.D.Gushulak, D.W.MacPherson. Globalization of infectious diseases: the impact of migration. Clin Infect Dis. 2004;38(12):1742–1748.
69. G.F.Gensini, M.H.Yacoub, A.A.Conti. The concept of quarantine in history: from plague to SARS. J Infect. 2004;49(4):257–261.
70. United Nations High Commissioner for Refugees. Practical guide to the systematic use of standards & indicators in UNHCR operations. 2nd ed. [updated Feb 2006; cited 2016 Feb 26]. Available from: http://www.unhcr.org/40eaa9804.pdf