Early treatment with intravenous lipid emulsion in a potentially lethal hydroxychloroquine intoxication

Netherlands Journal of Medicine

Volumn 74, Issue 5, 2016, Pages 210-214

  Ten Broeke, R ^a   Mestrom, E ^a   Woo, L ^a   Kreeftenberg, H ^a  

^a CATHARINA HOSPITAL   (Netherlands)

Author keywords

Hydroxychloroquine; Intoxication; Lipid rescue

Indexed keywords

BICARBONATE; CODEINE; DIAZEPAM; DOMPERIDONE; HEART ENZYME; HYDROXYCHLOROQUINE; LIPID EMULSION; NORADRENALIN; POTASSIUM CHLORIDE; VASOCONSTRICTOR AGENT;

ADULT; APNEA; ARTICLE; CARDIOMYOPATHY; CARDIOTOXICITY; CASE REPORT; ELECTROCARDIOGRAPHY; FEMALE; HEART MUSCLE CONDUCTION DISTURBANCE; HEART VENTRICLE CONDUCTION; HUMAN; HYDROXYCHLOROQUINE INTOXICATION; HYPOKALEMIA; HYPOTENSION; INTOXICATION; LIQUID CHROMATOGRAPHY; MALE; MEAN ARTERIAL PRESSURE; PLEURA EFFUSION; QRS COMPLEX; QRS WIDENING; QT PROLONGATION; QTC INTERVAL; TANDEM MASS SPECTROMETRY; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; UNCONSCIOUSNESS; VOMITING; YOUNG ADULT; ARRHYTHMIAS, CARDIAC; COMPLICATION; DRUG OVERDOSE; METABOLISM; PATHOPHYSIOLOGY; SUICIDE ATTEMPT;

ADULT; ARRHYTHMIAS, CARDIAC; CHROMATOGRAPHY, LIQUID; DRUG OVERDOSE; ELECTROCARDIOGRAPHY; FAT EMULSIONS, INTRAVENOUS; FEMALE; HUMANS; HYDROXYCHLOROQUINE; HYPOKALEMIA; HYPOTENSION; MALE; NOREPINEPHRINE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SUICIDE, ATTEMPTED; TANDEM MASS SPECTROMETRY; VASOCONSTRICTOR AGENTS;

EID: 84975219803     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wang LZ, Ong RY, Chin TM, et al. Method development and validation for rapid quantification of hydroxychloroquine in human blood using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2012;5;86-92.
2. Yanturali S, Aksay E, Demir OF, Atilla R. Massive hydroxychloroquine overdose. Acta Anaesthesiol Scand. 2004;48:379-81.
3. Chloroquine and related drugs. In: Poisindex® System [database on the internet]. Ann Arbor (MI): Truven Health Analytics; 2015 [cited 20 Dec 2015]. Available from: www.micromedexsolutions.com. Subscription required to view.
4. Keller T, Schneider A, Lamprecht R, Aderjan R, Tutsch-Bauer E, Kisser W. Fatal chloroquine intoxication. Forensic Sci Int. 1998;96:21-8.
5. Messant I, Jérémie N, Lenfant F, Freysz M. Massive chloroquine intoxication: importance of early treatment and pre-hospital treatment. Resuscitation. 2004;60:343-6.
6. Mébargane B, Bloch V, Hirt D, et al. Blood concentrations are better predictors of chloroquine poisoning severity than plasma concentrations: a prospective study with modelling of the concentration/effect relationships. Clin Toxicol. 2010;48:904-15.
7. Meeran K, Jacobs MG. Chloroquine poisoning, rapidly fatal without treatment. Br Med J. 1993;307:49-50.
8. Frisk-Holmberg M. Chloroquine intoxication. Br J Clin Pharm. 1983;15:502-3.
9. Boereboom FT, Ververs FF, Meulenbelt J, van Dijk A. Hemoperfusion is ineffectual in severe chloroquine poisoning. Crit Care Med. 2000;28:3346-50.
10. De Lange DW, Sikma MA, Meulenbelt J. Extracorporeal membrane oxygenation in the treatment of poisoned patients. Clin Toxicol. 2013;51:385-93.
11. Phipps C, Chan K, Teo F, Ponampalam R. Fatal chloroquine poisoning: A rare cause of sudden cardiac arrest. Ann Acad Med. 2011;40:296-7.
12. Clemessy JL, Favier C, Borron SW, Hantson PE, Vicaut E, Baud FJ. Hypokalaemia related to acute chloroquine ingestion. Lancet. 1995;346:877-80.
13. Clemessy JL, Taboulet P, Hoffmann JR, et al. Treatment of acute chloroquine poisoning: A 5 year experience. Crit Care Med. 1996;24:1189-95.
14. Riou B, Barriot P, Rimailho A, Baud FJ. Treatment of severe chloroquine poisoning. N Engl J Med. 1988;318:1-6.
15. Riou B, Rimailho A, Galliot M, Bourdon R, Huet Y. Protective cardiovascular effects of diazepam in experimental acute chloroquine poisoning. Intensive Care Med. 1988;14:610-16.
16. Clemessy JL, Angel G, Borron SW, et al. Therapeutic trial of diazepam versus placebo in acute chloroquine intoxications of moderate gravity. Intensive Care Med. 1996;22:1400-5.
17. Yanturali S. Diazepam for treatment of massive chloroquine intoxication. Resuscitation. 2004;63:347-8.
18. LipidRescue. http://www.lipidrescue.org/. December 2015.
19. French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol. 2011;49:801-9.
20. Haesendonck, R. Intravenous lipid emulsion for intentional chloroquine poisoning. Clin Toxicol. 2012;50:223.
21. Wong OF, Chan YC, Lam SK, Fung HT, Ho JKY. Clinical experience in the use of intravenous lipid emulsion in hydroxychloroquine and chloroquine overdose with refractory shock. Hong Kong J Emerg Med. 2011;18:243-8.
22. Cao D, Heard K, Foran M, Koyfman A. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015;48:387-97.