Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis among Apparently Healthy Adults

American Journal of Kidney Diseases

Volumn 68, Issue 1, 2016, Pages 58-67

  Denic, Aleksandar ^a   Alexander, Mariam P ^a   Kaushik, Vidhu ^a   Lerman, Lilach O ^a   Lieske, John C ^a   Stegall, Mark D ^a   Larson, Joseph J ^a   Kremers, Walter K ^a   Vrtiska, Terri J ^a   Chakkera, Harini A ^b   Poggio, Emilio D ^c   Rule, Andrew D ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

aging; arteriosclerosis; biopsy; chronic kidney disease (CKD) risk factor; contrast computed tomographic (CT) scan; high resolution imaging; hypertension; kidney function; kidney macrostructure; kidney microstructure; kidney volume; living kidney donor; nephron hypertrophy; Nephrosclerosis; subclinical renal pathology

Indexed keywords

ADULT; ARTERIOSCLEROSIS; ARTICLE; BODY MASS; BORDERLINE HYPERTENSION; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CROSS-SECTIONAL STUDY; FEMALE; FIBROSING ALVEOLITIS; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; IMAGE PROCESSING; KIDNEY BIOPSY; KIDNEY CORTEX; KIDNEY DONOR; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY STRUCTURE; MAJOR CLINICAL STUDY; MALE; NEPHROSCLEROSIS; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TUBULAR ATROPHY; CLINICAL TRIAL; HYPERTROPHY; MULTICENTER STUDY; NEPHRON; PATHOLOGY;

ADULT; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERTROPHY; MALE; NEPHRONS; NEPHROSCLEROSIS;

EID: 84975175121     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2015.12.029     Document Type: Article

References (50)

1. A.D. Rule, and R.J. Glassock GFR estimating equations: getting closer to the truth? Clin J Am Soc Nephrol 8 8 2013 1414 1420
2. H.J. Mattix, C.Y. Hsu, S. Shaykevich, and G. Curhan Use of the albumin/creatinine ratio to detect microalbuminuria: implications of sex and race J Am Soc Nephrol 13 4 2002 1034 1039
3. H. Hricak, C. Cruz, R. Romanski, and et al. Renal parenchymal disease: sonographic-histologic correlation Radiology 144 1 1982 141 147
4. E.M. Chung, R.M. Conran, J.W. Schroeder, I.R. Rohena-Quinquilla, and V.J. Rooks From the radiologic pathology archives: pediatric polycystic kidney disease and other ciliopathies: radiologic-pathologic correlation Radiographics 34 1 2014 155 178
5. A.T. Rosenfield, and N.J. Siegel Renal parenchymal disease: histopathologic-sonographic correlation AJR Am J Roentgenol 137 4 1981 793 798
6. P.J. Patel Renal parenchymal disease: histopathologic-sonographic correlation Urol Int 41 4 1986 289 291
7. J.F. Platt, J.H. Ellis, J.M. Rubin, M.A. DiPietro, and A.B. Sedman Intrarenal arterial Doppler sonography in patients with nonobstructive renal disease: correlation of resistive index with biopsy findings AJR Am J Roentgenol 154 6 1990 1223 1227
8. S.D. Roger, A.M. Beale, W.R. Cattell, and J.A. Webb What is the value of measuring renal parenchymal thickness before renal biopsy? Clin Radiol 49 1 1994 45 49
9. G.J. Lonergan, R.R. Rice, and E.S. Suarez Autosomal recessive polycystic kidney disease: radiologic-pathologic correlation Radiographics 20 3 2000 837 855
10. S. Moghazi, E. Jones, J. Schroepple, and et al. Correlation of renal histopathology with sonographic findings Kidney Int 67 4 2005 1515 1520
11. E.C. Lorenz, T.J. Vrtiska, J.C. Lieske, and et al. Prevalence of renal artery and kidney abnormalities by computed tomography among healthy adults Clin J Am Soc Nephrol 5 3 2010 431 438
12. A.D. Rule, K. Sasiwimonphan, J.C. Lieske, M.T. Keddis, V.E. Torres, and T.J. Vrtiska Characteristics of renal cystic and solid lesions based on contrast-enhanced computed tomography of potential kidney donors Am J Kidney Dis 59 5 2012 611 618
13. X. Duan, A.D. Rule, H. Elsherbiny, and et al. Automated assessment of renal cortical surface roughness from computerized tomography images and its association with age Acad Radiol 21 11 2014 1441 1445
14. X. Wang, T.J. Vrtiska, R.T. Avula, and et al. Age, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney Kidney Int 85 3 2014 677 685
15. S. Johnson, R. Rishi, A. Andone, and et al. Determinants and functional significance of renal parenchymal volume in adults Clin J Am Soc Nephrol 6 1 2011 70 76
16. A.D. Rule, H. Amer, L.D. Cornell, and et al. The association between age and nephrosclerosis on renal biopsy among healthy adults Ann Intern Med 152 9 2010 561 567
17. A.D. Rule, M.H. Semret, H. Amer, and et al. Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors Mayo Clin Proc 86 4 2011 282 290
18. H.E. Elsherbiny, M.P. Alexander, W.K. Kremers, and et al. Nephron hypertrophy and glomerulosclerosis and their association with kidney function and risk factors among living kidney donors Clin J Am Soc Nephrol 9 11 2014 1892 1902
19. T. Samuel, W.E. Hoy, R. Douglas-Denton, M.D. Hughson, and J.F. Bertram Determinants of glomerular volume in different cortical zones of the human kidney J Am Soc Nephrol 16 10 2005 3102 3109
20. E. Mancilla, C. Avila-Casado, N. Uribe-Uribe, and et al. Time-zero renal biopsy in living kidney transplantation: a valuable opportunity to correlate predonation clinical data with histological abnormalities Transplantation 86 12 2008 1684 1688
21. Y. Ohashi, G. Thomas, S. Nurko, and et al. Association of metabolic syndrome with kidney function and histology in living kidney donors Am J Transplant 13 9 2013 2342 2351
22. L.J. Melton 3rd The threat to medical-records research N Engl J Med 337 20 1997 1466 1470
23. E.D. Poggio, A.D. Rule, R. Tanchanco, and et al. Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors Kidney Int 75 10 2009 1079 1087
24. P.A. Yushkevich, J. Piven, H.C. Hazlett, and et al. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability Neuroimage 31 3 2006 1116 1128
25. W.J. Conover Practical Nonparametric Statistics 3rd ed. 1999 Wiley New York, NY
26. C.E. Alpers The kidney V. Kumar, AA N. Fausto, J.C. Aster, Robbins and Cotran Pathologic Basis of Disease 2010 Saunders-Elsevier Philadelphia, PA 905 970
27. I. Ishikawa Acquired cystic disease: mechanisms and manifestations Semin Nephrol 11 6 1991 671 684
28. M. Kessler, P. Testevuide, B. Aymard, and T.C. Huu Acquired renal cystic disease mimicking adult polycystic kidney disease in a patient undergoing long-term hemodialysis Am J Nephrol 11 6 1991 513 517
29. P.A. Preisig, and H.A. Franch Renal epithelial cell hyperplasia and hypertrophy Semin Nephrol 15 4 1995 327 340
30. J.S. Liu, I. Ishikawa, and T. Horiguchi Incidence of acquired renal cysts in biopsy specimens Nephron 84 2 2000 142 147
31. R. Konda, H. Sato, F. Hatafuku, T. Nozawa, N. Ioritani, and T. Fujioka Expression of hepatocyte growth factor and its receptor C-met in acquired renal cystic disease associated with renal cell carcinoma J Urol 171 6, pt 1 2004 2166 2170
32. C.M. Burchfiel, R.E. Tracy, P.H. Chyou, and J.P. Strong Cardiovascular risk factors and hyalinization of renal arterioles at autopsy. The Honolulu Heart Program Arterioscler Thromb Vasc Biol 17 4 1997 760 768
33. M. Kubo, Y. Kiyohara, I. Kato, and et al. Risk factors for renal glomerular and vascular changes in an autopsy-based population survey: the Hisayama Study Kidney Int 63 4 2003 1508 1515
34. T. Ninomiya, M. Kubo, Y. Doi, and et al. Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study J Am Soc Nephrol 18 7 2007 2135 2142
35. W.E. Hoy, R.N. Douglas-Denton, M.D. Hughson, A. Cass, K. Johnson, and J.F. Bertram A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy Kidney Int Suppl 83 2003 S31 S37
36. M. Hughson, A.B. Farris 3rd, R. Douglas-Denton, W.E. Hoy, and J.F. Bertram Glomerular number and size in autopsy kidneys: the relationship to birth weight Kidney Int 63 6 2003 2113 2122
37. W.E. Hoy, M.D. Hughson, J.F. Bertram, R. Douglas-Denton, and K. Amann Nephron number, hypertension, renal disease, and renal failure J Am Soc Nephrol 16 9 2005 2557 2564
38. W. Metcalfe How does early chronic kidney disease progress? A background paper prepared for the UK Consensus Conference on early chronic kidney disease Nephrol Dial Transplant 22 suppl 9 2007 ix26 ix30
39. V.A. Luyckx, and B.M. Brenner Low birth weight, nephron number, and kidney disease Kidney Int Suppl 97 2005 S68 S77
40. V.A. Luyckx, K. Shukha, and B.M. Brenner Low nephron number and its clinical consequences Rambam Maimonides Med J 2 4 2011 e0061
41. A. Tobar, Y. Ori, S. Benchetrit, and et al. Proximal tubular hypertrophy and enlarged glomerular and proximal tubular urinary space in obese subjects with proteinuria PLoS One 8 9 2013 e75547
42. V.G. Puelles, W.E. Hoy, M.D. Hughson, B. Diouf, R.N. Douglas-Denton, and J.F. Bertram Glomerular number and size variability and risk for kidney disease Curr Opin Nephrol Hypertens 20 1 2011 7 15
43. V.G. Puelles, M.A. Zimanyi, T. Samuel, and et al. Estimating individual glomerular volume in the human kidney: clinical perspectives Nephrol Dial Transplant 27 5 2012 1880 1888
44. P. Rossing, L. Tarnow, F.S. Nielsen, B.V. Hansen, B.M. Brenner, and H.H. Parving Low birth weight. A risk factor for development of diabetic nephropathy? Diabetes 44 12 1995 1405 1407
45. T. Nakagawa, M. Mazzali, D.H. Kang, and et al. Hyperuricemia causes glomerular hypertrophy in the rat Am J Nephrol 23 1 2003 2 7
46. M.D. Hughson, V.G. Puelles, W.E. Hoy, R.N. Douglas-Denton, S.A. Mott, and J.F. Bertram Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race Nephrol Dial Transplant 29 7 2014 1399 1409
47. N. Shiraishi, K. Kitamura, Y. Kohda, K. Iseki, and K. Tomita Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population Clin Exp Nephrol 18 3 2014 461 468
48. Z. Karam, and J. Tuazon Anatomic and physiologic changes of the aging kidney Clin Geriatr Med 29 3 2013 555 564
49. D. Bolignano, F. Mattace-Raso, E.J. Sijbrands, and C. Zoccali The aging kidney revisited: a systematic review Ageing Res Rev 14 2014 65 80
50. J.E. Martin, and M.T. Sheaff Renal ageing J Pathol 211 2 2007 198 205