Anatomic and Physiologic Changes of the Aging Kidney

Clinics in Geriatric Medicine

Volumn 29, Issue 3, 2013, Pages 555-564

  Karam, Zeina ^a   Tuazon, Jennifer ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Functional reserve; Glomerular filtration rate; Glomerulosclerosis; Osmoregulation; Renal blood flow; Renal mass; Renin angiotensin system; Senescence

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANGIOTENSIN II; FIBRONECTIN; NITRIC OXIDE; TRANSFORMING GROWTH FACTOR BETA;

ACID BASE BALANCE; AGING; ARTERIOSCLEROSIS; CAPILLARY PERMEABILITY; GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY; KIDNEY BLOOD FLOW; KIDNEY CONCENTRATING CAPACITY; KIDNEY CORTEX; KIDNEY CYST; KIDNEY FIBROSIS; KIDNEY MEDULLA; KIDNEY SIZE; NONHUMAN; OSMOREGULATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEINURIA; REVIEW; SENESCENCE; SODIUM ABSORPTION; WATER ABSORPTION;

FUNCTIONAL RESERVE; GLOMERULAR FILTRATION RATE; GLOMERULOSCLEROSIS; OSMOREGULATION; RENAL BLOOD FLOW; RENAL MASS; RENIN-ANGIOTENSIN SYSTEM; SENESCENCE;

AGING; CELL AGING; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY CONCENTRATING ABILITY; ORGAN DYSFUNCTION SCORES; OXIDATIVE STRESS; RENAL CIRCULATION; RENAL INSUFFICIENCY; WATER-ELECTROLYTE IMBALANCE;

EID: 84880114285     PISSN: 07490690     EISSN: 18798853     Source Type: Journal    
DOI: 10.1016/j.cger.2013.05.006     Document Type: Review

References (54)

1. Lindeman R.D., Tobin J., Shock N.W. Longitudinal studies on the rate of decline in renal function with age. JAm Geriatr Soc 1985, 33:278-285.
2. Perico N., Remuzzi G., Benigni A. Aging and the kidney. Curr Opin Nephrol Hypertens 2011, 20:312-317.
3. Kanasaki K., Kitada M., Koya D. Pathophysiology of the aging kidney and therapeutic interventions. Hypertens Res 2012, 35:1121-1128.
4. Yang H., Fogo A. Cell senescence in the aging kidney. JAm Soc Nephrol 2010, 21:1436-1439.
5. Zhou X., Saxena R., Liu Z., et al. Renal senescence in 2008: progress and challenges. Int Urol Nephrol 2008, 40:823-839.
6. Martin J.E., Sheaff M.T. Renal ageing. JPathol 2007, 211:198-205.
7. Glassock R., Rule A. The implications of anatomic and functional changes in the aging kidney: with an emphasis on the glomeruli. Kidney Int 2010, 80:270-277.
8. Ruler A.D., Amer H., Cornell L.D., et al. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med 2010, 152:561-567.
9. McLachlan M., Wasserman P. Changes in the size and distensibility of the aging kidney. Br J Radiol 1981, 54:488-491.
10. Rao U.V., Wagner H.N. Normal weights of human organs. Radiology 1972, 102:337-339.
11. Kasiske B.L., Umen A.J. The influence of age, sex, race and body habitus on kidney weight in humans. Arch Pathol Lab Med 1986, 110:55-60.
12. Goyal V.K. Changes with age in the human kidney. Exp Gerontol 1982, 17:321-331.
13. Hoy W.E., Douglas-Denton R.N., Highson M.D., et al. Astereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 2003, 63:S31-S37.
14. Abdi R., Slakey D., Kittur D. Heterogeneity of glomerular size in normal donor kidneys: impact of race. Am J Kidney Dis 1998, 32:43-46.
15. Rule A.D., Semret M.H., Amer H., et al. Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors. Mayo Clin Proc 2011, 86:282-290.
16. Anderson S., Brenner B.M. Effects of aging on the renal glomerulus. Am J Med 1986, 80(3):435-442.
17. Lauks S.P., McClachlan M.S. Aging and simple cysts of the kidney. Br J Radiol 1981, 54(637):12-14.
18. Lindeman R.D., Goldman R. Anatomic and physiologic age changes in the kidney. Exp Gerontol 1986, 21(4-5):379-406.
19. Takizawa T., Takasaki I., Shionoiri H., et al. Progression of glomerulosclerosis, renal hypertrophy, and an increased expression of fibronectin in the renal cortex associated with aging and salt-induced hypertension in Dahl salt-sensitive rats. Life Sci 1997, 61(16):1553-1558.
20. Gagliano N., Arioso B., Santanbrogio B., et al. Age-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex. JGerontol A Biol Sci Med Sci 2000, 55(8):365-372.
21. McDonald R.K., Solomon D.H., Shock N.W. Aging as a factor in the renal hemodynamic changes induced by a standard pyrogen. JClin Invest 1951, 5:457-462.
22. Kubo M., Kyiohara Y., Kato I., et al. Risk factors of renal glomerular and vascular changes in an autopsy based population survey: the Hisayama study. Kidney Int 2003, 63:1508-1515.
23. McLachlan M.S., Guthrie J.C., Anderson C.K., et al. Vascular and glomerular changes in the ageing kidney. JPathol 1977, 121:65-78.
24. Hollenberg N.K., Adams D.F., Solomon H.S., et al. Senescence and the renal vasculature in normal man. Circ Res 1974, 34:309-316.
25. Thomas M.C., Tikellis C., Burns W.M., et al. Interactions between renin angiotensin system and advanced glycation in the kidney. JAm Soc Nephrol 2005, 16:2976-2984.
26. Ruiz-Torres M.P., Bosch R.J., O'Valle F., et al. Age-related increase in expression of TGF-beta1 in the rat kidney: relationship to morphologic changes. JAm Soc Nephrol 1998, 9:782-791.
27. Weidmann P., De Myttenaere-Bursztein S., Maxwell M.H., et al. Effect of aging on plasma renin and aldosterone in normal man. Kidney Int 1975, 8:325-333.
28. Cogan M.G. Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 1990, 15:451-458.
29. Norman J.T. The role of angiotensin II in renal growth. Ren Physiol Biochem 1991, 14:175-185.
30. Choudhury D., Levi M. Kidney aging-inevitable or preventable. Nat Rev Nephrol 2011, 7:706-717.
31. Ma L.J., Nakamura S., Aldigier A.C., et al. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. JAm Soc Nephrol 2005, 16:966-976.
32. Weinstein J., Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis 2010, 17(4):302-307.
33. Llorens S., Fernandez A.P., Nava E. Cardiovascular and renal alterations on the nitric oxide pathway in spontaneous hypertension and ageing. Clin Hemorheol Microcirc 2007, 37:149-156.
34. Fortepiani L.A., Yanes L., Zhang H., et al. Role of androgens in mediating renal injury in aging SHR. Hypertension 2003, 42:952-955.
35. Rowe J.W., Andres R.A., Tobin J.D., et al. The effect of age on creatinine clearance in man: a cross-sectional and longitudinal study. JGerontol 1976, 311:155-163.
36. Epstein M. Aging and the kidney. JAm Soc Nephrol 1996, 7:1106-1122.
37. Fliser D., Zeler M., Nowack R., et al. Renal function reserve in healthy elderly subjects. JAm Soc Nephrol 1993, 3:1371-1377.
38. Hollenberg N.K., Rivera A., Meinking A., et al. Age, renal perfusion and function in island dwelling indigenous Kuna Americans of Panama. Nephron 1999, 82:131-138.
39. Rule A.D., Cornell L.D., Poggio E.D. Senile nephrosclerosis-does it explain the decline in glomerular filtration rate with aging?. Nephron Physiol 2011, 119(Suppl 1):6-11.
40. Davies D.F., Shock N.W. Age changes in glomerular filtration, effective renal plasma flow and tubular excretory capacity in adult males. JClin Invest 1950, 29:496-506.
41. Davies D.F., Shock N.W. Renal blood flow. JClin Invest 1950, 29:496-500.
42. Bolton W.K., Benton F.R., Maclay J.G., et al. Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. Am J Pathol 1976, 85:227-302.
43. Cohen M.P., Ku L. Age-related changes in sulfation of basement membrane glycosaminoglycans. Exp Gerontol 1976, 18:447-450.
44. Schalekamp M.A., Krauss X.H., Schalekamp-Kuyken M.P., et al. Studies on themechanism of hypernatriuresis in essential hypertension in relation to measurement of plasma renin concentration, body fluid compartment and renal function. Clin Sci 1971, 41:219-231.
45. Lindeman R.D., Lee D.T., Yiegst M.J., et al. Influence of age, renal disease, hypertension, diuretics and calcium on the antidiuretic responses to suboptimal infusions of vasopressin. JLab Clin Med 1966, 68:202-223.
46. Preisser L., Teillet L., Aliotti S., et al. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Am J Physiol Renal Physiol 2000, 279:F144-F152.
47. Rowe J.W., Shock N.W., DeFronzo R.A. The influence of age on renal response to water deprivation in man. Nephron 1976, 17:270-278.
48. Lindeman R.D., Van Burenc H.C., Raisz L.G. Osmolar renal concentrating ability in healthy young men and hospitalized patients without renal disease. NEngl J Med 1960, 262:1306-1309.
49. Faubert P.F., Porush J.G. Renal disease in the elderly 1998, Marcel Dekker, New York, p. 15-128. 2nd edition.
50. Epstein M., Hollenberg N.K. Age as a determinant of renal sodium conservation in normal man. JLab Clin Med 1976, 87:411-417.
51. Miller M. Hormonal aspects of fluid and sodium balance in the elderly. Endocrinol Metab Clin North Am 1995, 24:233-253.
52. Wagner E.A., Falciglia G.A., Amlal H., et al. Short-term exposure to a high-protein diet differentially affects glomerular filtration rate but not acid-base balance in older compared to younger adults. JAm Diet Assoc 2007, 107:1404-1408.
53. Perez G.O., Lespier L., Jacobi J. Hyporeninemia and hypoaldosteronism in diabetes mellitus. Arch Intern Med 1977, 137:852-855.
54. Phelps K.R., Lieberman R.L., Oh M.S., et al. Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. Metabolism 1980, 29:186-199.