A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas

Journal of Neurosurgery

Volumn 124, Issue 5, 2016, Pages 1300-1309

  Lau, Darryl ^a   Hervey Jumper, Shawn L ^a   Chang, Susan ^a   Molinaro, Annette M ^a,b   McDermott, Michael W ^a   Phillips, Joanna J ^a   Berger, Mitchel S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Division of Epidemiology and Biostatistics   (United States)

Author keywords

Aminolevulinic acid; Cellularity; Fluorescence; Glioblastoma; High grade glioma; Oncology

Indexed keywords

AMINOLEVULINIC ACID;

ABDOMINAL DISCOMFORT; ADULT; ARTICLE; CANCER SURGERY; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CORRELATIONAL STUDY; DIZZINESS; FEMALE; FLUORESCENCE; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOTENSION; INTRAOPERATIVE PERIOD; MAJOR CLINICAL STUDY; MALE; NAUSEA; OPEN STUDY; OUTCOME ASSESSMENT; PATIENT SAFETY; PHASE 2 CLINICAL TRIAL; PHOTOSENSITIVITY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TUMOR BIOPSY; TUMOR RECURRENCE; VOMITING; BIOPSY; BRAIN; BRAIN NEOPLASMS; CELL COUNT; CLASSIFICATION; CLINICAL TRIAL; COMPUTER ASSISTED SURGERY; FLUORESCENCE IMAGING; GLIOBLASTOMA; MIDDLE AGED; PATHOLOGY; PEROPERATIVE CARE; PROGNOSIS; STATISTICS;

AMINOLEVULINIC ACID; BIOPSY; BRAIN; BRAIN NEOPLASMS; CELL COUNT; FEMALE; GLIOBLASTOMA; GLIOMA; HUMANS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OPTICAL IMAGING; PROGNOSIS; STATISTICS AS TOPIC; SURGERY, COMPUTER-ASSISTED;

EID: 84975117274     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2015.5.JNS1577     Document Type: Article

References (37)

1. Albert FK, Forsting M, Sartor K, Adams HP, Kunze S: Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 34:45-61, 1994
2. Arita H, Kinoshita M, Kagawa N, Fujimoto Y, Kishima H, Hashimoto N, et al: C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic imagehistological analysis. Cancer 118:1619-1627, 2012
3. Barker FG II, Prados MD, Chang SM, Gutin PH, Lamborn KR, Larson DA, et al: Radiation response and survival time in patients with glioblastoma multiforme. J Neurosurg 84:442-448, 1996
4. Chung IW, Eljamel S: Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection. Photodiagn Photodyn Ther 10:362-367, 2013
5. Della Puppa A, Ciccarino P, Lombardi G, Rolma G, Cecchin D, Rossetto M: 5-Aminolevulinic acid fluorescence in high grade glioma surgery: surgical outcome, intraoperative findings, and fluorescence patterns. BioMed Res Int 2014:232561, 2014
6. Della Puppa A, De Pellegrin S, d'Avella E, Gioffrè G, Rossetto M, Gerardi A, et al: 5-aminolevulinic acid (5-ALA) fluorescence guided surgery of high-grade gliomas in eloquent areas assisted by functional mapping. Our experience and review of the literature. Acta Neurochir (Wien) 155:965-972, 2013
7. Dietze A, Berg K: ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies. Photodiagn Photodyn Ther 2:299-307, 2005
8. Díez Valle R, Tejada Solis S, Idoate Gastearena MA, García de Eulate R, Domínguez Echávarri P, Aristu Mendiroz J: Surgery guided by 5-aminolevulinic fluorescence in glioblastoma: volumetric analysis of extent of resection in singlecenter experience. J Neurooncol 102:105-113, 2011
9. Hefti M, von Campe G, Moschopulos M, Siegner A, Looser H, Landolt H: 5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institution. Swiss Med Wkly 138:180-185, 2008
10. Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, et al: Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med 5:201ra119, 2013
11. Kamp MA, Grosser P, Felsberg J, Slotty PJ, Steiger HJ, Reifenberger G, et al: 5-aminolevulinic acid (5-ALA)-induced fluorescence in intracerebral metastases: a retrospective study. Acta Neurochir (Wien) 154:223-228, 2012
12. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95:190-198, 2001
13. Lindner D, Trantakis C, Renner C, Arnold S, Schmitgen A, Schneider J, et al: Application of intraoperative 3D ultrasound during navigated tumor resection. Minim Invasive Neurosurg 49:197-202, 2006
14. Marko NF, Weil RJ, Schroeder JL, Lang FF, Suki D, Sawaya RE: Extent of resection of glioblastoma revisited: personalized survival modeling facilitates more accurate survival prediction and supports a maximum-safe-resection approach to surgery. J Clin Oncol 32:774-782, 2014
15. Nimsky C, Ganslandt O, Buchfelder M, Fahlbusch R: Intraoperative visualization for resection of gliomas: the role of functional neuronavigation and intraoperative 1. 5 T MRI. Neurol Res 28:482-487, 2006
16. Orringer D, Lau D, Khatri S, Zamora-Berridi GJ, Zhang K, Wu C, et al: Extent of resection in patients with glioblastoma: limiting factors, perception of resectability, and effect on survival. J Neurosurg 117:851-859, 2012
17. Panciani PP, Fontanella M, Garbossa D, Agnoletti A, Ducati A, Lanotte M: 5-aminolevulinic acid and neuronavigation in high-grade glioma surgery: results of a combined approach. Neurocirugia (Astur) 23:23-28, 2012
18. Piccirillo SG, Dietz S, Madhu B, Griffiths J, Price SJ, Collins VP, et al: Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin. Br J Cancer 107:462-468, 2012
19. Regula J, MacRobert AJ, Gorchein A, Buonaccorsi GA, Thorpe SM, Spencer GM, et al: Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX-a pilot study. Gut 36:67-75, 1995
20. Roberts DW, Valdés PA, Harris BT, Fontaine KM, Hartov A, Fan X, et al: Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between daminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article. J Neurosurg 114:595-603, 2011
21. Sanai N, Polley MY, McDermott MW, Parsa AT, Berger MS: An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg 115:3-8, 2011
22. Schucht P, Beck J, Abu-Isa J, Andereggen L, Murek M, Seidel K, et al: Gross total resection rates in contemporary glioblastoma surgery: results of an institutional protocol combining 5-aminolevulinic acid intraoperative fluorescence imaging and brain mapping. Neurosurgery 71:927-936, 2012
23. Shinoda J, Yano H, Yoshimura S, Okumura A, Kaku Y, Iwama T, et al: Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium. Technical note. J Neurosurg 99:597-603, 2003
24. Simpson JR, Horton J, Scott C, Curran WJ, Rubin P, Fischbach J, et al: Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26:239-244, 1993
25. Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ: Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 93:1003-1013, 2000
26. Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 7:392-401, 2006
27. Stummer W, Stocker S, Novotny A, Heimann A, Sauer O, Kempski O, et al: In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid. J Photochem Photobiol B 45:160-169, 1998
28. Stummer W, Stocker S, Wagner S, Stepp H, Fritsch C, Goetz C, et al: Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery 42:518-526, 1998
29. Stummer W, Tonn JC, Goetz C, Ullrich W, Stepp H, Bink A, et al: 5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging. Neurosurgery 74:310-320, 2014
30. Utsuki S, Oka H, Sato S, Shimizu S, Suzuki S, Tanizaki Y, et al: Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance. Neurol Med Chir (Tokyo) 47:210-214, 2007
31. Valdés PA, Kim A, Brantsch M, Niu C, Moses ZB, Tosteson TD, et al: d-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro Oncol 13:846-856, 2011
32. Valdés PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, et al: Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg 115:11-17, 2011
33. Vecht CJ, Avezaat CJ, van Putten WL, Eijkenboom WM, Stefanko SZ: The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients. J Neurol Neurosurg Psychiatry 53:466-471, 1990
34. Widhalm G, Minchev G, Woehrer A, Preusser M, Kiesel B, Furtner J, et al: Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies. Neurosurg Rev 35:381-391, 2012
35. Willems PW, Taphoorn MJ, Burger H, Berkelbach van der Sprenkel JW, Tulleken CA: Effectiveness of neuronavigation in resecting solitary intracerebral contrast-enhancing tumors: a randomized controlled trial. J Neurosurg 104:360-368, 2006
36. Wirtz CR, Albert FK, Schwaderer M, Heuer C, Staubert A, Tronnier VM, et al: The benefit of neuronavigation for neurosurgery analyzed by its impact on glioblastoma surgery. Neurol Res 22:354-360, 2000
37. Zhao S, Wu J, Wang C, Liu H, Dong X, Shi C, et al: Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies. PLoS One 8:e63682, 2013