메뉴 건너뛰기




Volumn 76, Issue 11, 2016, Pages 3156-3165

Myeloid-derived suppressor cells endow stem-like qualities to breast cancer cells through IL6/STAT3 and NO/NOTCH cross-talk signaling

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; NOTCH RECEPTOR; STAT3 PROTEIN; MESSENGER RNA; NITRIC OXIDE;

EID: 84975090456     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-2528     Document Type: Article
Times cited : (223)

References (46)
  • 2
    • 84855360800 scopus 로고    scopus 로고
    • Targeting and utilizing primary tumors as live vaccines: Changing strategies
    • Yang X, Mortenson ED, Fu YX. Targeting and utilizing primary tumors as live vaccines: changing strategies. Cell Mol Immunol 2012;9:20-6.
    • (2012) Cell Mol Immunol , vol.9 , pp. 20-26
    • Yang, X.1    Mortenson, E.D.2    Fu, Y.X.3
  • 4
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM.The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 5
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W.Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005;5:263-74.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 6
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea-a paradigm shift
    • Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea-a paradigm shift. Cancer Res 2006;66:1883-90.
    • (2006) Cancer Res , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 7
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-84.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 8
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - An integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005;5:744-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 9
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 10
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007;449:557-63.
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5    Bell, G.W.6
  • 11
    • 84887512876 scopus 로고    scopus 로고
    • CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis
    • Katoh H, Wang D, Daikoku T, Sun H, Dey SK, Dubois RN. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 2013;24:631-44.
    • (2013) Cancer Cell , vol.24 , pp. 631-644
    • Katoh, H.1    Wang, D.2    Daikoku, T.3    Sun, H.4    Dey, S.K.5    Dubois, R.N.6
  • 12
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 13
    • 84884354300 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing micro-RNA101 and suppressing the corepressor CtBP2
    • Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing micro-RNA101 and suppressing the corepressor CtBP2. Immunity 2013;39:611-21.
    • (2013) Immunity , vol.39 , pp. 611-621
    • Cui, T.X.1    Kryczek, I.2    Zhao, L.3    Zhao, E.4    Kuick, R.5    Roh, M.H.6
  • 14
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009;16:91-102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • DeNardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6
  • 15
    • 84900459331 scopus 로고    scopus 로고
    • IL-22(+)CD4 (+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22(+)CD4 (+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 2014;40:772-84.
    • (2014) Immunity , vol.40 , pp. 772-784
    • Kryczek, I.1    Lin, Y.2    Nagarsheth, N.3    Peng, D.4    Zhao, L.5    Zhao, E.6
  • 16
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    • Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 2009;457:102-6.
    • (2009) Nature , vol.457 , pp. 102-106
    • Kim, S.1    Takahashi, H.2    Lin, W.W.3    Descargues, P.4    Grivennikov, S.5    Kim, Y.6
  • 17
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011;475:222-5.
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3    Kitamura, T.4    Zhang, J.5    Campion, L.R.6
  • 18
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 19
    • 84861399789 scopus 로고    scopus 로고
    • S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites
    • Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C, et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012;21:642-54.
    • (2012) Cancer Cell , vol.21 , pp. 642-654
    • Deng, J.1    Liu, Y.2    Lee, H.3    Herrmann, A.4    Zhang, W.5    Zhang, C.6
  • 20
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007;117:3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 21
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 22
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009;15:103-13.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 23
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44 (+)CD24(-) stem cell-like breast cancer cells in human tumors
    • Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44 (+)CD24(-) stem cell-like breast cancer cells in human tumors. J Clin Invest 2011;121:2723-35.
    • (2011) J Clin Invest , vol.121 , pp. 2723-2735
    • Marotta, L.L.1    Almendro, V.2    Marusyk, A.3    Shipitsin, M.4    Schemme, J.5    Walker, S.R.6
  • 24
    • 80255137100 scopus 로고    scopus 로고
    • Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells
    • Kryczek I, Liu S, Roh M, Vatan L, Szeliga W, Wei S, et al. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer 2012;130:29-39.
    • (2012) Int J Cancer , vol.130 , pp. 29-39
    • Kryczek, I.1    Liu, S.2    Roh, M.3    Vatan, L.4    Szeliga, W.5    Wei, S.6
  • 25
    • 84900459331 scopus 로고    scopus 로고
    • IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 2014;40:772-84.
    • (2014) Immunity , vol.40 , pp. 772-784
    • Kryczek, I.1    Lin, Y.2    Nagarsheth, N.3    Peng, D.4    Zhao, L.5    Zhao, E.6
  • 26
    • 84884126500 scopus 로고    scopus 로고
    • Phase III trial of sunitinib in combination with capecitabine versus capecitabine monotherapy for the treatment of patients with pretreated metastatic breast cancer
    • Crown JP, Dieras V, Staroslawska E, Yardley DA, Bachelot T, Davidson N, et al. Phase III trial of sunitinib in combination with capecitabine versus capecitabine monotherapy for the treatment of patients with pretreated metastatic breast cancer. J Clin Oncol 2013;31:2870-8.
    • (2013) J Clin Oncol , vol.31 , pp. 2870-2878
    • Crown, J.P.1    Dieras, V.2    Staroslawska, E.3    Yardley, D.A.4    Bachelot, T.5    Davidson, N.6
  • 27
    • 84894047241 scopus 로고    scopus 로고
    • A phase II, randomized, multicenter study evaluating the combination of lapatinib and vinorelbine in women with ErbB2 overexpressing metastatic breast cancer
    • Janni W, Sarosiek T, Karaszewska B, Pikiel J, Staroslawska E, Potemski P, et al. A phase II, randomized, multicenter study evaluating the combination of lapatinib and vinorelbine in women with ErbB2 overexpressing metastatic breast cancer. Breast Cancer Res Treat 2014;143:493-505.
    • (2014) Breast Cancer Res Treat , vol.143 , pp. 493-505
    • Janni, W.1    Sarosiek, T.2    Karaszewska, B.3    Pikiel, J.4    Staroslawska, E.5    Potemski, P.6
  • 28
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003;9:562-7.
    • (2003) Nat Med , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 29
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 30
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 2006;203:871-81.
    • (2006) J Exp Med , vol.203 , pp. 871-881
    • Kryczek, I.1    Zou, L.2    Rodriguez, P.3    Zhu, G.4    Wei, S.5    Mottram, P.6
  • 33
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 34
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1:555-67.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 35
    • 48649090161 scopus 로고    scopus 로고
    • Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion
    • Choi JH, Park JT, Davidson B, Morin PJ, Shih Ie M, Wang TL. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res 2008;68:5716-23.
    • (2008) Cancer Res , vol.68 , pp. 5716-5723
    • Choi, J.H.1    Park, J.T.2    Davidson, B.3    Morin, P.J.4    Shih Ie, M.5    Wang, T.L.6
  • 36
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research N. Integrated genomic analyses of ovarian carcinoma. Nature 2011;474:609-15.
    • (2011) Nature , vol.474 , pp. 609-615
    • Cancer Genome Atlas Research N1
  • 37
    • 0034661719 scopus 로고    scopus 로고
    • +myeloid cells derived from tumorbearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation
    • +myeloid cells derived from tumorbearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol 2000;165:779-85.
    • (2000) J Immunol , vol.165 , pp. 779-785
    • Kusmartsev, S.A.1    Li, Y.2    Chen, S.H.3
  • 38
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-74.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 39
    • 84899959071 scopus 로고    scopus 로고
    • Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    • Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, et al. Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother 2014;63: 513-28.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 513-528
    • Panni, R.Z.1    Sanford, D.E.2    Belt, B.A.3    Mitchem, J.B.4    Worley, L.A.5    Goetz, B.D.6
  • 40
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, Zhao E, Kryczek I, Vatan L, Sadovskaya A, Ludema G, et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 2014;147:1393-404.
    • (2014) Gastroenterology , vol.147 , pp. 1393-1404
    • Wan, S.1    Zhao, E.2    Kryczek, I.3    Vatan, L.4    Sadovskaya, A.5    Ludema, G.6
  • 41
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 2009;58:49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 42
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, et al. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010;6:141-52.
    • (2010) Cell Stem Cell , vol.6 , pp. 141-152
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3    Bleau, A.M.4    Brennan, C.W.5    Hambardzumyan, D.6
  • 43
    • 79957933050 scopus 로고    scopus 로고
    • Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells
    • Mukherjee T, Kim WS, Mandal L, Banerjee U. Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. Science 2011;332:1210-3.
    • (2011) Science , vol.332 , pp. 1210-1213
    • Mukherjee, T.1    Kim, W.S.2    Mandal, L.3    Banerjee, U.4
  • 44
    • 77955534002 scopus 로고    scopus 로고
    • The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity
    • Park S, Jiang Z, Mortenson ED, Deng L, Radkevich-Brown O, Yang X, et al. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell 2010;18:160-70.
    • (2010) Cancer Cell , vol.18 , pp. 160-170
    • Park, S.1    Jiang, Z.2    Mortenson, E.D.3    Deng, L.4    Radkevich-Brown, O.5    Yang, X.6
  • 45
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • Denardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov 2011;1:54-67.
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • Denardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5    Madden, S.F.6
  • 46
    • 84859899567 scopus 로고    scopus 로고
    • Acute myeloid leukemia stem cells and CD33-targeted immunotherapy
    • Walter RB, Appelbaum FR, Estey EH, Bernstein ID. Acute myeloid leukemia stem cells and CD33-targeted immunotherapy. Blood 2012;119:6198-208.
    • (2012) Blood , vol.119 , pp. 6198-6208
    • Walter, R.B.1    Appelbaum, F.R.2    Estey, E.H.3    Bernstein, I.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.