Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes

FASEB Journal

Volumn 30, Issue 1, 2016, Pages 141-148

  Zwart, Sara R ^a   Gregory, Jesse F ^b   Zeisel, Steven H ^c   Gibson, Charles R ^d   Mader, Thomas H ^e   Kinchen, Jason M ^f   Ueland, Per M ^g   Ploutz Snyder, Robert ^a   Heer, Martina A ^h   Smith, Scott M ⁱ  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Coastal Eye Associates ^*  (United States)

^e Cooper Landing ^*  (United States)

^f METABOLON INC   (United States)

^g UNIVERSITY OF BERGEN   (Norway)

^h UNIVERSITY OF BONN   (Germany)

ⁱ NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANDROGEN; CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; ENZYME; FERRITIN; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; METHIONINE SYNTHASE REDUCTASE; PRASTERONE; PYRIDOXINE; RIBOFLAVIN; TESTOSTERONE; VITAMIN B GROUP; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; SHMT PROTEIN, HUMAN; VITAMIN;

ADULT; ARTICLE; CARBON METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; COSMONAUT; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIATION; GENOTYPE; HUMAN; MALE; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPACE FLIGHT; TESTOSTERONE BLOOD LEVEL; VISUAL DISORDER; AGED; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; VISION;

ADULT; AGED; ANDROGENS; FEMALE; FERREDOXIN-NADP REDUCTASE; GENOTYPE; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SPACE FLIGHT; VISUAL PERCEPTION; VITAMINS;

EID: 84974784600     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-278457     Document Type: Article

References (38)

1. Mader, T. H., Gibson, C. R., Pass, A. F., Kramer, L. A., Lee, A. G., Fogarty, J., Tarver, W. J., Dervay, J. P., Hamilton, D. R., Sargsyan, A., Phillips, J. L., Tran, D., Lipsky, W., Choi, J., Stern, C., Kuyumjian, R., and Polk, J. D. (2011) Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 118, 2058-2069
2. Marshall-Bowman, K., Barratt, M. R., and Gibson, C. R. (2013) Ophthalmic changes and increased intracranial pressure associated with long duration spaceflight: an emerging understanding. Acta Astronaut. 87, 77-87
3. Zwart, S. R., Gibson, C. R., Mader, T. H., Ericson, K., Ploutz-Snyder, R., Heer, M., and Smith, S. M. (2012) Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. J. Nutr. 142, 427-431
4. Davis, S. R., Quinlivan, E. P., Shelnutt, K. P., Maneval, D. R., Ghandour, H., Capdevila, A., Coats, B. S., Wagner, C., Selhub, J., Bailey, L. B., Shuster, J. J., Stacpoole, P. W., and Gregory III, J. F. (2005) The methylenetetrahydrofolate reductase 677C→T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women. J. Nutr. 135, 1040-1044
5. Kluijtmans, L. A., Young, I. S., Boreham, C. A., Murray, L., McMaster, D., McNulty, H., Strain, J. J., McPartlin, J., Scott, J. M., and Whitehead, A. S. (2003) Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 101, 2483-2488
6. Glueck, C. J., Aregawi, D., Goldenberg, N., Golnik, K. C., Sieve, L., and Wang, P. (2005) Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia. J. Lab. Clin. Med. 145, 72-82
7. Finsterer, J., Kuntscher, D., Brunner, S., and Krugluger, W. (2007) Pseudotumor cerebri from sinus venous thrombosis, associated with polycystic ovary syndrome and hereditary hypercoagulability. Gynecol. Endocrinol. 23, 179-182
8. Klein, A., Stern, N., Osher, E., Kliper, E., and Kesler, A. (2013) Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women. Curr. Eye Res. 38, 972-976
9. Smith, S. M., Heer, M., Wang, Z., Huntoon, C. L., and Zwart, S. R. (2012) Long-duration space flight and bed rest effects on testosterone and other steroids. J. Clin. Endocrinol. Metab. 97, 270-278, correction 3390
10. Shin, S. Y., Fauman, E. B., Petersen, A. K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., Yang, T. P., Walter, K., Menni, C., Chen, L., Vasquez, L., Valdes, A. M., Hyde, C. L., Wang, V., Ziemek, D., Roberts, P., Xi, L., Grundberg, E., Waldenberger, M., Richards, J. B., Mohney, R. P., Milburn, M. V., John, S. L., Trimmer, J., Theis, F. J., Overington, J. P., Suhre, K., Brosnan, M. J., Gieger, C., Kastenmüller, G., Spector, T. D., Soranzo, N., and Soranzo, N.; Multiple Tissue Human Expression Resource (MuTHER) Consortium. (2014) An atlas of genetic influences on human blood metabolites. Nat. Genet. 46, 543-550
11. Zwart, S. R., Crawford, G. E., Gillman, P. L., Kala, G., Rodgers, A. S., Rogers, A., Inniss, A. M., Rice, B. L., Ericson, K., Coburn, S., Bourbeau, Y., Hudson, E., Mathew, G., Dekerlegand, D. E., Sams, C. F., Heer, M. A., Paloski, W. H., and Smith, S. M. (2009) Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans. J. Appl. Physiol. 107, 54-62
12. Zwart, S. R., Morgan, J. L., and Smith, S. M. (2013) Iron status and its relations with oxidative damage and bone loss during long-duration space flight on the International Space Station. Am. J. Clin. Nutr. 98, 217-223
13. García-Minguillán, C. J., Fernandez-Ballart, J. D., Ceruelo, S., Ríos, L., Bueno, O., Berrocal-Zaragoza, M. I., Molloy, A. M., Ueland, P. M., Meyer, K., and Murphy, M. M. (2014) Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine. Genes Nutr. 9, 435
14. Vijaya Lakshmi, S. V., Naushad, S. M., Seshagiri Rao, D., and Kutala, V. K. (2013) Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease. Cell Biochem. Biophys. 67, 353-361
15. Demir, M., Guven, D., Koc, A., Ozdemir, S., and Can, E. (2013) Retinal nerve fiber layer thickness in women with polycystic ovary syndrome. J. Ophthalmol. 2013, 752186
16. Wenner, M. M., Taylor, H. S., and Stachenfeld, N. S. (2013) Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. Am. J. Physiol. Endocrinol. Metab. 305, E818-E825
17. Sprung, V. S., Cuthbertson, D. J., Pugh, C. J., Daousi, C., Atkinson, G., Aziz, N. F., Kemp, G. J., Green, D. J., Cable, N. T., and Jones, H. (2013) Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary sydrome but can be improved by exercise training. J. Physiol. 591, 1475-1487
18. Randeva, H. S., Tan, B. K., Weickert, M. O., Lois, K., Nestler, J. E., Sattar, N., and Lehnert, H. (2012) Cardiometabolic aspects of the polycystic ovary syndrome. Endocr. Rev. 33, 812-841
19. Daan, N. M., Louwers, Y. V., Koster, M. P., Eijkemans, M. J., de Rijke, Y. B., Lentjes, E. W., Fauser, B. C., and Laven, J. S. (2014) Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? Fertil. Steril. 102, 1444-1451.e3
20. March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I., Norman, R. J., and Davies, M. J. (2010) The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod. 25, 544-551
21. Maleedhu, P., M, V., S S B, S., Kodumuri, P. K., and Devi D, V. (2014) Status of homocysteine in polycystic ovary syndrome (PCOS). J. Clin. Diagn. Res. 8, 31-33
22. Loverro, G., Lorusso, F., Mei, L., Depalo, R., Cormio, G., and Selvaggi, L. (2002) The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecol. Obstet. Invest. 53, 157-162
23. Grodnitskaya, E. E., and Kurtser, M. A. (2012) Homocysteine metabolism in polycystic ovary syndrome. Gynecol. Endocrinol. 28, 186-189
24. Yilmaz, M., Bukan, N., Ersoy, R., Karakoç, A., Yetkin, I., Ayvaz, G., Cakir, N., and Arslan, M. (2005) Glucose intolerance, insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndrome. Hum. Reprod. 20, 2414-2420
25. Shin, S. H., Kim, Y. M., Kim, H. Y., Lee, Y. J., and Nam, S. O. (2014) Idiopathic intracranial hypertension associated with polycystic ovarian syndrome. Pediatr. Int. 56, 411-413
26. Avisar, I., Gaton, D. D., Dania, H., and Stiebel-Kalish, H. (2012) The prevalence of polycystic ovary syndrome in women with idiopathic intracranial hypertension. Scientifica (Cairo) 2012, 708042
27. Örnek, N., İnal, M., Tulmaç, O. B., Özcan-Daǧ, Z., and Örnek, K. (2015) Ocular blood flow in polycystic ovary syndrome. J. Obstet. Gynaecol. Res. 41, 1080-1086
28. Sirek, A. S., Garcia, K., Foy, M., Ebert, D., Sargsyan, A., Wu, J. H., and Dulchavsky, S. A. (2014) Doppler ultrasound of the central retinal artery in microgravity. Aviat. Space Environ. Med. 85, 3-8
29. Jones, K. J. (1988) Steroid hormones and neurotrophism: relationship to nerve injury. Metab. Brain Dis. 3, 1-18
30. Heimark, D., McAllister, J., and Larner, J. (2014) Decreased myoinositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr. J. 61, 111-117
31. Liu, D. M., Torchen, L. C., Sung, Y., Paparodis, R., Legro, R. S., Grebe, S. K., Singh, R. J., Taylor, R. L., and Dunaif, A. (2014) Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome. Hum. Reprod. 29, 2764-2772
32. Kurzrock, R., and Cohen, P. R. (2007) Polycystic ovary syndrome in men: Stein-Leventhal syndrome revisited. Med. Hypotheses 68, 480-483
33. Kapoor, K. G. (2009) Secondary pseudotumour cerebri in a patient undergoing sexual reassignment therapy [comment]. Clin. Exp. Optom. 92, 519-520, author reply 520
34. Mowl, A. D., Grogg, J. A., and Klein, J. (2009) Secondary pseudotumour cerebri in a patient undergoing sexual reassignment therapy. Clin. Exp. Optom. 92, 449-453
35. Sanborn, T. A., Kowle, R. L., and Sallach, H. J. (1975) Regulation of enzymes of serine and one-carbon metabolism by testosterone in rat prostate, liver, and kidney. Endocrinology 97, 1000-1007
36. Gaughan, D. J., Kluijtmans, L. A., Barbaux, S., McMaster, D., Young, I. S., Yarnell, J. W., Evans, A., and Whitehead, A. S. (2001) The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 157, 451-456
37. Nilsson, T. K., Böttiger, A. K., Henríquez, P., and Serra Majem, L. (2014) MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. Mol. Med. Rep. 10, 2706-2712
38. Liang, S., Zhou, Y., Wang, H., Qian, Y., Ma, D., Tian, W., Persaud-Sharma, V., Yu, C., Ren, Y., Zhou, S., and Li, X. (2014) The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism. BioMed Res. Int. 2014, 560183