메뉴 건너뛰기




Volumn 7, Issue MAY, 2016, Pages

NADPH oxidase-derived ROS induced by chronic intermittent hypoxia mediates hypersensitivity of lung vagal C fibers in rats

Author keywords

Airway hypersensitivity; Chronic intermittent hypoxia; Lung vagal C fibers; NADPH oxidase; Reactive oxygen species

Indexed keywords

ADENOSINE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; APOCYNIN; CAPSAICIN; MANGANESE TETRAKIS(1 METHYL 4 PYRIDYL)PORPHYRIN; MEMBRANE PROTEIN; PROTEIN P47PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; UNCLASSIFIED DRUG;

EID: 84974627515     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2016.00166     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 33846818524 scopus 로고    scopus 로고
    • Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
    • Abramov, A. Y., Scorziello, A., and Duchen, M. R. (2007). Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci. 27, 1129-1138. doi: 10.1523/JNEUROSCI.4468-06.2007
    • (2007) J. Neurosci , vol.27 , pp. 1129-1138
    • Abramov, A.Y.1    Scorziello, A.2    Duchen, M.R.3
  • 2
    • 67650245608 scopus 로고    scopus 로고
    • Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial
    • Alonso-Fernandez, A., Garcia-Rio, F., Arias, M. A., Hernanz, A., de la Pena, M., Pierola, J., et al. (2009). Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial. Thorax 64, 581-586. doi: 10.1136/thx.2008.100537
    • (2009) Thorax , vol.64 , pp. 581-586
    • Alonso-Fernandez, A.1    Garcia-Rio, F.2    Arias, M.A.3    Hernanz, A.4    de la Pena, M.5    Pierola, J.6
  • 3
    • 18144439066 scopus 로고
    • Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium
    • Chakraborti, S., Gurtner, G. H., and Michael, J. R. (1989). Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium. Am. J. Physiol. 257, L430-437.
    • (1989) Am. J. Physiol , vol.257 , pp. L430-L437
    • Chakraborti, S.1    Gurtner, G.H.2    Michael, J.R.3
  • 4
    • 16344396656 scopus 로고    scopus 로고
    • Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome
    • Ciftci, T. U., Ciftci, B., Guven, S. F., Kokturk, O., and Turktas, H. (2005). Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome. Respir. Med. 99, 529-534. doi: 10.1016/j.rmed.2004.10.011
    • (2005) Respir. Med , vol.99 , pp. 529-534
    • Ciftci, T.U.1    Ciftci, B.2    Guven, S.F.3    Kokturk, O.4    Turktas, H.5
  • 5
    • 0021299663 scopus 로고
    • Afferent vagal C fibre innervation of the lungs and airways and its functional significance
    • Coleridge, J. C., and Coleridge, H. M. (1984). Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99, 1-110. doi: 10.1007/bfb0027715
    • (1984) Rev. Physiol. Biochem. Pharmacol , vol.99 , pp. 1-110
    • Coleridge, J.C.1    Coleridge, H.M.2
  • 6
    • 84870427719 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia increases apnoea index in sleeping rats
    • Edge, D., Bradford, A., and O'Halloran, K. D. (2012). Chronic intermittent hypoxia increases apnoea index in sleeping rats. Adv. Exp. Med. Biol. 758, 359-363. doi: 10.1007/978-94-007-4584-1_48
    • (2012) Adv. Exp. Med. Biol , vol.758 , pp. 359-363
    • Edge, D.1    Bradford, A.2    O'Halloran, K.D.3
  • 7
    • 0042423422 scopus 로고    scopus 로고
    • Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats
    • Gu, Q., Ruan, T., Hong, J. L., Burki, N., and Lee, L. Y. (2003). Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats. J. Appl. Physiol. 95, 1315-1324. doi: 10.1152/japplphysiol.00107.2003
    • (2003) J. Appl. Physiol , vol.95 , pp. 1315-1324
    • Gu, Q.1    Ruan, T.2    Hong, J.L.3    Burki, N.4    Lee, L.Y.5
  • 8
    • 0033845835 scopus 로고    scopus 로고
    • Prostaglandin E(2) enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat
    • Ho, C. Y., Gu, Q., Hong, J. L., and Lee, L. Y. (2000). Prostaglandin E(2) enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat. Am. J. Respir. Crit. Care Med. 162, 528-533. doi: 10.1164/ajrccm.162.2.9910059
    • (2000) Am. J. Respir. Crit. Care Med , vol.162 , pp. 528-533
    • Ho, C.Y.1    Gu, Q.2    Hong, J.L.3    Lee, L.Y.4
  • 9
    • 0034899135 scopus 로고    scopus 로고
    • Sensitivity of vagal afferent endings to chemical irritants in the rat lung
    • Ho, C. Y., Gu, Q., Lin, Y. S., and Lee, L. Y. (2001). Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir. Physiol. 127, 113-124. doi: 10.1016/S0034-5687(01)00241-9
    • (2001) Respir. Physiol , vol.127 , pp. 113-124
    • Ho, C.Y.1    Gu, Q.2    Lin, Y.S.3    Lee, L.Y.4
  • 10
    • 84975491744 scopus 로고    scopus 로고
    • Obstructive sleep apnea syndrome: links betwen pathophysiology and cardiovascular complications
    • Hopps, E., and Caimi, G. (2015). Obstructive sleep apnea syndrome: links betwen pathophysiology and cardiovascular complications. Clin. Invest. Med. 38, E362-E370.
    • (2015) Clin. Invest. Med , vol.38 , pp. E362-E370
    • Hopps, E.1    Caimi, G.2
  • 11
    • 80052472579 scopus 로고    scopus 로고
    • Airway inflammation and hypersensitivity induced by chronic smoking
    • Kou, Y. R., Kwong, K., and Lee, L. Y. (2011). Airway inflammation and hypersensitivity induced by chronic smoking. Respir. Physiol. Neurobiol. 178, 395-405. doi: 10.1016/j.resp.2011.03.004
    • (2011) Respir. Physiol. Neurobiol , vol.178 , pp. 395-405
    • Kou, Y.R.1    Kwong, K.2    Lee, L.Y.3
  • 12
    • 0029064428 scopus 로고
    • Role of vagal afferents in the acute ventilatory responses to inhaled wood smoke in rats
    • Kou, Y. R., Wang, C. Y., and Lai, C. J. (1995). Role of vagal afferents in the acute ventilatory responses to inhaled wood smoke in rats. J. Appl. Physiol. 78, 2070-2078.
    • (1995) J. Appl. Physiol , vol.78 , pp. 2070-2078
    • Kou, Y.R.1    Wang, C.Y.2    Lai, C.J.3
  • 13
    • 78650176969 scopus 로고    scopus 로고
    • Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats
    • Kuo, T. B., Yuan, Z. F., Lin, Y. S., Lin, Y. N., Li, W. S., Yang, C. C., et al. (2011). Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats. Respir. Physiol. Neurobiol. 175, 70-79. doi: 10.1016/j.resp.2010.09.010
    • (2011) Respir. Physiol. Neurobiol , vol.175 , pp. 70-79
    • Kuo, T.B.1    Yuan, Z.F.2    Lin, Y.S.3    Lin, Y.N.4    Li, W.S.5    Yang, C.C.6
  • 14
    • 0031908662 scopus 로고    scopus 로고
    • Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats
    • Lai, C. J., and Kou, Y. R. (1998). Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats. J. Appl. Physiol. 84, 30-36.
    • (1998) J. Appl. Physiol , vol.84 , pp. 30-36
    • Lai, C.J.1    Kou, Y.R.2
  • 15
    • 33744944517 scopus 로고    scopus 로고
    • Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats
    • Lai, C. J., Yang, C. C., Hsu, Y. Y., Lin, Y. N., and Kuo, T. B. (2006). Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats. J. Appl. Physiol. 100, 1974-1982. doi: 10.1152/japplphysiol.01051.2005
    • (2006) J. Appl. Physiol , vol.100 , pp. 1974-1982
    • Lai, C.J.1    Yang, C.C.2    Hsu, Y.Y.3    Lin, Y.N.4    Kuo, T.B.5
  • 16
    • 0037316130 scopus 로고    scopus 로고
    • Obstructive sleep apnoea syndrome-an oxidative stress disorder
    • Lavie, L. (2003). Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med. Rev. 7, 35-51. doi: 10.1053/smrv.2002.0261
    • (2003) Sleep Med. Rev , vol.7 , pp. 35-51
    • Lavie, L.1
  • 17
    • 0035116372 scopus 로고    scopus 로고
    • Afferent properties and reflex functions of bronchopulmonary C-fibers
    • Lee, L. Y., and Pisarri, T. E. (2001). Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir. Physiol. 125, 47-65. doi: 10.1016/S0034-5687(00)00204-8
    • (2001) Respir. Physiol , vol.125 , pp. 47-65
    • Lee, L.Y.1    Pisarri, T.E.2
  • 18
    • 0028795394 scopus 로고
    • Obstructive sleep apnea syndrome and bronchial hyperreactivity
    • Lin, C. C., and Lin, C. Y. (1995). Obstructive sleep apnea syndrome and bronchial hyperreactivity. Lung 173, 117-126. doi: 10.1007/BF02981471
    • (1995) Lung , vol.173 , pp. 117-126
    • Lin, C.C.1    Lin, C.Y.2
  • 19
    • 84873468667 scopus 로고    scopus 로고
    • Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C fibers to intravenous agonists
    • Lin, Y. J., Lin, Y. S., Lai, C. J., Yuan, Z. F., Ruan, T., and Kou, Y. R. (2013). Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C fibers to intravenous agonists. J. Appl. Physiol. 114, 361-370. doi: 10.1152/japplphysiol.00977.2012
    • (2013) J. Appl. Physiol , vol.114 , pp. 361-370
    • Lin, Y.J.1    Lin, Y.S.2    Lai, C.J.3    Yuan, Z.F.4    Ruan, T.5    Kou, Y.R.6
  • 20
    • 66149119054 scopus 로고    scopus 로고
    • Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors
    • Lin, Y. S., Lin, R. L., Bien, M. Y., Ho, C. Y., and Kou, Y. R. (2009). Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. J. Appl. Physiol. 106, 1142-1152. doi: 10.1152/japplphysiol.91229.2008
    • (2009) J. Appl. Physiol , vol.106 , pp. 1142-1152
    • Lin, Y.S.1    Lin, R.L.2    Bien, M.Y.3    Ho, C.Y.4    Kou, Y.R.5
  • 21
    • 77949571119 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor
    • Marcus, N. J., Li, Y. L., Bird, C. E., Schultz, H. D., and Morgan, B. J. (2010). Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor. Respir. Physiol. Neurobiol. 171, 36-45. doi: 10.1016/j.resp.2010.02.003
    • (2010) Respir. Physiol. Neurobiol , vol.171 , pp. 36-45
    • Marcus, N.J.1    Li, Y.L.2    Bird, C.E.3    Schultz, H.D.4    Morgan, B.J.5
  • 22
    • 0036216024 scopus 로고    scopus 로고
    • Effects of various reactive oxygen species on the guinea pig trachea and its epithelium
    • Matyas, S., Pucovsky, V., and Bauer, V. (2002). Effects of various reactive oxygen species on the guinea pig trachea and its epithelium. Jpn. J. Pharmacol. 88, 270-278. doi: 10.1254/jjp.88.270
    • (2002) Jpn. J. Pharmacol , vol.88 , pp. 270-278
    • Matyas, S.1    Pucovsky, V.2    Bauer, V.3
  • 23
    • 84920896801 scopus 로고    scopus 로고
    • Metabolic dysfunction in obstructive sleep apnea: a critical examination of underlying mechanisms
    • Mesarwi, O. A., Sharma, E. V., Jun, J. C., and Polotsky, V. Y. (2015). Metabolic dysfunction in obstructive sleep apnea: a critical examination of underlying mechanisms. Sleep Biol. Rhythms 13, 2-17. doi: 10.1111/sbr.12078
    • (2015) Sleep Biol. Rhythms , vol.13 , pp. 2-17
    • Mesarwi, O.A.1    Sharma, E.V.2    Jun, J.C.3    Polotsky, V.Y.4
  • 24
    • 84857233841 scopus 로고    scopus 로고
    • Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species
    • Mittal, M., Gu, X. Q., Pak, O., Pamenter, M. E., Haag, D., Fuchs, D. B., et al. (2012). Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. Free. Radic. Biol. Med. 52, 1033-1042. doi: 10.1016/j.freeradbiomed.2011.12.004
    • (2012) Free. Radic. Biol. Med , vol.52 , pp. 1033-1042
    • Mittal, M.1    Gu, X.Q.2    Pak, O.3    Pamenter, M.E.4    Haag, D.5    Fuchs, D.B.6
  • 25
    • 65349186285 scopus 로고    scopus 로고
    • The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice
    • Nisbet, R. E., Graves, A. S., Kleinhenz, D. J., Rupnow, H. L., Reed, A. L., Fan, T. H., et al. (2009). The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Am. J. Respir. Cell Mol. Biol. 40, 601-609. doi: 10.1165/2008-0145OC
    • (2009) Am. J. Respir. Cell Mol. Biol , vol.40 , pp. 601-609
    • Nisbet, R.E.1    Graves, A.S.2    Kleinhenz, D.J.3    Rupnow, H.L.4    Reed, A.L.5    Fan, T.H.6
  • 26
    • 65549160457 scopus 로고    scopus 로고
    • NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia
    • Peng, Y. J., Nanduri, J., Yuan, G., Wang, N., Deneris, E., Pendyala, S., et al. (2009). NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J. Neurosci. 29, 4903-4910. doi: 10.1523/JNEUROSCI.4768-08.2009
    • (2009) J. Neurosci , vol.29 , pp. 4903-4910
    • Peng, Y.J.1    Nanduri, J.2    Yuan, G.3    Wang, N.4    Deneris, E.5    Pendyala, S.6
  • 27
    • 0036342349 scopus 로고    scopus 로고
    • Ventilatory changes during intermittent hypoxia: importance of pattern and duration
    • Prabhakar, N. R., and Kline, D. D. (2002). Ventilatory changes during intermittent hypoxia: importance of pattern and duration. High Alt. Med. Biol. 3, 195-204. doi: 10.1089/15270290260131920
    • (2002) High Alt. Med. Biol , vol.3 , pp. 195-204
    • Prabhakar, N.R.1    Kline, D.D.2
  • 28
    • 0035061344 scopus 로고    scopus 로고
    • Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms
    • Prabhakar, N. R. (2001). Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J. Appl. Physiol. 90, 1986-1994.
    • (2001) J. Appl. Physiol , vol.90 , pp. 1986-1994
    • Prabhakar, N.R.1
  • 29
    • 80052453224 scopus 로고    scopus 로고
    • Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance
    • Prabhakar, N. R. (2011). Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance. Respir. Physiol. Neurobiol. 178, 375-380. doi: 10.1016/j.resp.2011.05.012
    • (2011) Respir. Physiol. Neurobiol , vol.178 , pp. 375-380
    • Prabhakar, N.R.1
  • 30
    • 84899109832 scopus 로고    scopus 로고
    • Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors
    • Ruan, T., Lin, Y. J., Hsu, T. H., Lu, S. H., Jow, G. M., and Kou, Y. R. (2014). Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors. PLoS ONE 9:e91763. doi: 10.1371/journal.pone.0091763
    • (2014) PLoS ONE , vol.9
    • Ruan, T.1    Lin, Y.J.2    Hsu, T.H.3    Lu, S.H.4    Jow, G.M.5    Kou, Y.R.6
  • 31
    • 84892969411 scopus 로고    scopus 로고
    • Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2
    • Schulz, R., Murzabekova, G., Egemnazarov, B., Kraut, S., Eisele, H. J., Dumitrascu, R., et al. (2014). Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2. J. Hypertens. 32, 300-305. doi: 10.1097/HJH.0000000000000016
    • (2014) J. Hypertens , vol.32 , pp. 300-305
    • Schulz, R.1    Murzabekova, G.2    Egemnazarov, B.3    Kraut, S.4    Eisele, H.J.5    Dumitrascu, R.6
  • 32
    • 84870555575 scopus 로고    scopus 로고
    • Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1
    • Shen, M. Y., Luo, Y. L., Yang, C. H., Ruan, T., and Lai, C. J. (2012). Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303, R1175-R1185. doi: 10.1152/ajpregu.00227.2012
    • (2012) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.303 , pp. R1175-R1185
    • Shen, M.Y.1    Luo, Y.L.2    Yang, C.H.3    Ruan, T.4    Lai, C.J.5
  • 33
    • 77950851985 scopus 로고    scopus 로고
    • Chronic cough and obstructive sleep apnea in a community-based pulmonary practice
    • Sundar, K. M., Daly, S. E., Pearce, M. J., and Alward, W. T. (2010). Chronic cough and obstructive sleep apnea in a community-based pulmonary practice. Cough 6:2. doi: 10.1186/1745-9974-6-2
    • (2010) Cough , vol.6 , pp. 2
    • Sundar, K.M.1    Daly, S.E.2    Pearce, M.J.3    Alward, W.T.4
  • 34
    • 33748445549 scopus 로고    scopus 로고
    • Transduction mechanisms in airway sensory nerves
    • Taylor-Clark, T., and Undem, B. J. (2006). Transduction mechanisms in airway sensory nerves. J. Appl. Physiol. 101, 950-959. doi: 10.1152/japplphysiol.00222.2006
    • (2006) J. Appl. Physiol , vol.101 , pp. 950-959
    • Taylor-Clark, T.1    Undem, B.J.2
  • 35
    • 80052450196 scopus 로고    scopus 로고
    • Sensing pulmonary oxidative stress by lung vagal afferents
    • Taylor-Clark, T. E., and Undem, B. J. (2011). Sensing pulmonary oxidative stress by lung vagal afferents. Respir. Physiol. Neurobiol. 178, 406-413. doi: 10.1016/j.resp.2011.05.003
    • (2011) Respir. Physiol. Neurobiol , vol.178 , pp. 406-413
    • Taylor-Clark, T.E.1    Undem, B.J.2
  • 36
    • 84863944863 scopus 로고    scopus 로고
    • Association of obstructive sleep apnea risk or diagnosis with daytime asthma in adults
    • Teodorescu, M., Polomis, D. A., Teodorescu, M. C., Gangnon, R. E., Peterson, A. G., Consens, F. B., et al. (2012). Association of obstructive sleep apnea risk or diagnosis with daytime asthma in adults. J. Asthma 49, 620-628. doi: 10.3109/02770903.2012.689408
    • (2012) J. Asthma , vol.49 , pp. 620-628
    • Teodorescu, M.1    Polomis, D.A.2    Teodorescu, M.C.3    Gangnon, R.E.4    Peterson, A.G.5    Consens, F.B.6
  • 37
    • 33745818879 scopus 로고    scopus 로고
    • Neural and hydroxyl radical mechanisms underlying laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats
    • Tsai, T. L., Chang, S. Y., Ho, C. Y., and Kou, Y. R. (2006). Neural and hydroxyl radical mechanisms underlying laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. J. Appl. Physiol. 101, 328-338. doi: 10.1152/japplphysiol.00064.2006
    • (2006) J. Appl. Physiol , vol.101 , pp. 328-338
    • Tsai, T.L.1    Chang, S.Y.2    Ho, C.Y.3    Kou, Y.R.4
  • 38
    • 66349111412 scopus 로고    scopus 로고
    • Role of ATP in the ROS-mediated laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats
    • Tsai, T. L., Chang, S. Y., Ho, C. Y., and Kou, Y. R. (2009). Role of ATP in the ROS-mediated laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. J. Appl. Physiol. 106, 1584-1592. doi: 10.1152/japplphysiol.91517.2008
    • (2009) J. Appl. Physiol , vol.106 , pp. 1584-1592
    • Tsai, T.L.1    Chang, S.Y.2    Ho, C.Y.3    Kou, Y.R.4
  • 39
    • 0037300275 scopus 로고    scopus 로고
    • Overview of neural pathways in allergy and asthma
    • Widdicombe, J. G. (2003). Overview of neural pathways in allergy and asthma. Pulm Pharmacol Ther. 16, 23-30. doi: 10.1016/S1094-5539(02)00178-5
    • (2003) Pulm Pharmacol Ther , vol.16 , pp. 23-30
    • Widdicombe, J.G.1
  • 40
    • 84874569582 scopus 로고    scopus 로고
    • Making sense of oxidative stress in obstructive sleep apnea: mediator or distracter?
    • Zhang, J., and Veasey, S. (2012). Making sense of oxidative stress in obstructive sleep apnea: mediator or distracter? Front. Neurol. 3:179. doi: 10.3389/fneur.2012.00179
    • (2012) Front. Neurol , vol.3 , pp. 179
    • Zhang, J.1    Veasey, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.