Testing Rare-Variant Association without Calling Genotypes Allows for Systematic Differences in Sequencing between Cases and Controls

PLoS Genetics

Volumn 12, Issue 5, 2016, Pages

  Hu, Yi Juan ^a   Liao, Peizhou ^a   Johnston, H Richard ^a   Allen, Andrew S ^b   Satten, Glen A ^c  

^a EMORY UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BTBD18 GENE; EXON; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HAPLOTYPE; HOMOZYGOTE; HUMAN; INTRON; NEXT GENERATION SEQUENCING; SINGLE NUCLEOTIDE VARIANT; SYSTEMATIC ERROR; VALIDATION PROCESS; ALGORITHM; CASE CONTROL STUDY; DNA SEQUENCE; GENETIC VARIATION; GENETICS; GENOTYPE; HIGH THROUGHPUT SEQUENCING; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; SOFTWARE; STATISTICAL MODEL;

ALGORITHMS; CASE-CONTROL STUDIES; GENETIC VARIATION; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; LIKELIHOOD FUNCTIONS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SOFTWARE;

EID: 84974555829     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006040     Document Type: Article

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