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1
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84898731305
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A controlled trial of renal denervation for resistant hypertension
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COI: 1:CAS:528:DC%2BC2cXmsVWrurg%3D, PID: 24678939, Only major sham-controlled trial of renal denervation. It did not demonstrate any difference between renal denervation and sham procedure with respect to office blood pressure
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Bhatt DL, Kandzari DE, O’Neill WW, D’Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370(15):1393–401. Only major sham-controlled trial of renal denervation. It did not demonstrate any difference between renal denervation and sham procedure with respect to office blood pressure.
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(2014)
N Engl J Med
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Bhatt, D.L.1
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D’Agostino, R.4
Flack, J.M.5
Katzen, B.T.6
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2
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84903935402
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Renal denervation and Symplicity HTN-3: “Dubium sapientiae initium” (doubt is the beginning of wisdom)
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COI: 1:CAS:528:DC%2BC2cXhtVOgtL%2FF, PID: 24989489
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Papademetriou V, Tsioufis C, Doumas M. Renal denervation and Symplicity HTN-3: “Dubium sapientiae initium” (doubt is the beginning of wisdom). Circ Res. 2014;115(2):211–4.
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Circ Res
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Papademetriou, V.1
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84906573276
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Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings
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PID: 25151320
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Esler M. Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings. J Am Soc Hypertens. 2014;8(8):593–8.
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J Am Soc Hypertens
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Esler, M.1
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Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
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Symplicity HTN-2 Investigators, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):1903–9.
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5
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64049084640
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Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
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PID: 19332353
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Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275–81.
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6
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84948439672
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A randomized trial of intensive versus standard blood-pressure control
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Group SR, Wright Jr JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103–16.
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N Engl J Med
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Group, S.R.1
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Whelton, P.K.4
Snyder, J.K.5
Sink, K.M.6
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7
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27544498604
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Treatment of resistant hypertension
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COI: 1:CAS:528:DC%2BD2MXht1Cmu7nI, PID: 16157072
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Taler SJ. Treatment of resistant hypertension. Curr Hypertens Rep. 2005;7(5):323–9.
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Curr Hypertens Rep
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Taler, S.J.1
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8
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84919719002
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Hypertension and new treatment approaches targeting the sympathetic nervous system
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COI: 1:CAS:528:DC%2BC2MXltVektw%3D%3D, PID: 25541034
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Laffin LJ, Bakris GL. Hypertension and new treatment approaches targeting the sympathetic nervous system. Curr Opin Pharmacol. 2015;21:20–4.
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Laffin, L.J.1
Bakris, G.L.2
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9
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84903908799
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Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3
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PID: 24858423
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Bakris GL, Townsend RR, Liu M, Cohen SA, D’Agostino R, Flack JM, et al. Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3. J Am Coll Cardiol. 2014;64(11):1071–8.
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J Am Coll Cardiol
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Bakris, G.L.1
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Flack, J.M.6
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10
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84930344607
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12-month blood pressure results of catheter-based renal artery denervation for resistant hypertension: the SYMPLICITY HTN-3 trial
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PID: 25835443, 12-month ambulatory and office blood pressure results from SYMPLICITY HTN-3. Data support no further reduction in office or ambulatory BP after 1-year of follow-up
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Bakris GL, Townsend RR, Flack JM, Brar S, Cohen SA, D’Agostino R, et al. 12-month blood pressure results of catheter-based renal artery denervation for resistant hypertension: the SYMPLICITY HTN-3 trial. J Am Coll Cardiol. 2015;65(13):1314–21. 12-month ambulatory and office blood pressure results from SYMPLICITY HTN-3. Data support no further reduction in office or ambulatory BP after 1-year of follow-up.
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(2015)
J Am Coll Cardiol
, vol.65
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, pp. 1314-1321
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Bakris, G.L.1
Townsend, R.R.2
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Brar, S.4
Cohen, S.A.5
D’Agostino, R.6
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11
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84929267450
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Frequency of renal artery stenosis after renal denervation in patients with resistant arterial hypertension
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PID: 25846764
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Lambert T, Nahler A, Reiter C, Schwarz S, Gammer V, Blessberger H, et al. Frequency of renal artery stenosis after renal denervation in patients with resistant arterial hypertension. Am J Cardiol. 2015;115(11):1545–8.
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Am J Cardiol
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Lambert, T.1
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12
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84957431259
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Mid-term vascular safety of renal denervation assessed by follow-up MR imaging
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PID: 26253780
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Schmid A, Schmieder R, Lell M, Janka R, Veelken R, Schmieder RE, et al. Mid-term vascular safety of renal denervation assessed by follow-up MR imaging. Cardiovasc Intervent Radiol. 2016;39(3):426–32.
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Schmid, A.1
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Schmieder, R.E.6
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13
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84905981330
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Anatomic assessment of sympathetic peri-arterial renal nerves in man
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PID: 25125292
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Sakakura K, Ladich E, Cheng Q, Otsuka F, Yahagi K, Fowler DR, et al. Anatomic assessment of sympathetic peri-arterial renal nerves in man. J Am Coll Cardiol. 2014;64(7):635–43.
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Sakakura, K.1
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Fowler, D.R.6
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14
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84924426046
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Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
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PID: 25400162
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Kandzari DE, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M, et al. Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J. 2015;36(4):219–27.
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Eur Heart J
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Kandzari, D.E.1
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Brar, S.3
Devireddy, C.M.4
Esler, M.5
Fahy, M.6
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15
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84944037367
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Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation
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PID: 26483099, Preclinical porcine model of renal denervation established following negative results of SYMPLICITY HTN-3 that characterizes the types of ablations needed to maximally decrease norepinephrine levels and renal vasculature axon density
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Mahfoud F, Tunev S, Ewen S, Cremers B, Ruwart J, Schulz-Jander D, et al. Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation. J Am Coll Cardiol. 2015;66(16):1766–75. Preclinical porcine model of renal denervation established following negative results of SYMPLICITY HTN-3 that characterizes the types of ablations needed to maximally decrease norepinephrine levels and renal vasculature axon density.
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(2015)
J Am Coll Cardiol
, vol.66
, Issue.16
, pp. 1766-1775
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Mahfoud, F.1
Tunev, S.2
Ewen, S.3
Cremers, B.4
Ruwart, J.5
Schulz-Jander, D.6
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16
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84898720409
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Renal denervation for resistant hypertension?
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COI: 1:CAS:528:DC%2BC2cXmsVWru70%3D, PID: 24678938
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Messerli FH, Bangalore S. Renal denervation for resistant hypertension? N Engl J Med. 2014;370(15):1454–7.
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Messerli, F.H.1
Bangalore, S.2
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17
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84947863698
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Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
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COI: 1:CAS:528:DC%2BC2MXhsFehsbjL, PID: 26414968
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Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet. 2015;386(10008):2059–68.
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(2015)
Lancet
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Williams, B.1
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Morant, S.3
Webb, D.J.4
Sever, P.5
McInnes, G.6
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18
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84921596261
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Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 Study
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COI: 1:CAS:528:DC%2BC2MXktFWrtA%3D%3D, PID: 25421981
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Rosa J, Widimsky P, Tousek P, Petrak O, Curila K, Waldauf P, et al. Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 Study. Hypertension. 2015;65(2):407–13.
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(2015)
Hypertension
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Rosa, J.1
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19
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84954397218
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Role of adding spironolactone and renal denervation in true resistant hypertension: one-year outcomes of randomized PRAGUE-15 Study
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COI: 1:CAS:528:DC%2BC28XitVKju7g%3D, PID: 26693818
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Rosa J, Widimsky P, Waldauf P, Lambert L, Zelinka T, Taborsky M, et al. Role of adding spironolactone and renal denervation in true resistant hypertension: one-year outcomes of randomized PRAGUE-15 Study. Hypertension. 2016;67(2):397–403.
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Hypertension
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Rosa, J.1
Widimsky, P.2
Waldauf, P.3
Lambert, L.4
Zelinka, T.5
Taborsky, M.6
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20
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84929606094
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Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial
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PID: 25631070
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Azizi M, Sapoval M, Gosse P, Monge M, Bobrie G, Delsart P, et al. Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet. 2015;385(9981):1957–65.
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Lancet
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Azizi, M.1
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21
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84981203568
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Renal denervation vs pharmacotherapy for resistant hypertension: a meta-analysis
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Meta-analysis of 9 renal denervation versus pharmacotherapy trials in resistant hypertension, of which 6 were randomized. When only accounting for 6 randomized trials there was no difference in blood pressure lowering with renal denervation versus pharmacotherapy
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Sun D, Li C, Li M, Liu J, Wen S. Renal denervation vs pharmacotherapy for resistant hypertension: a meta-analysis. J Clin Hypertens (Greenwich). 2015. doi:10.1111/jch.12742. Meta-analysis of 9 renal denervation versus pharmacotherapy trials in resistant hypertension, of which 6 were randomized. When only accounting for 6 randomized trials there was no difference in blood pressure lowering with renal denervation versus pharmacotherapy.
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(2015)
J Clin Hypertens (Greenwich).
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Sun, D.1
Li, C.2
Li, M.3
Liu, J.4
Wen, S.5
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22
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First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension
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PID: 25691618, First published data from a prospective registry created to document the long-term safety and effectiveness of renal denervation in a real world patient population with hypertension. It also aims to gather data for other diseases characterized by elevated sympathetic drive
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Bohm M, Mahfoud F, Ukena C, Hoppe UC, Narkiewicz K, Negoita M, et al. First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension. Hypertension. 2015;65(4):766–74. First published data from a prospective registry created to document the long-term safety and effectiveness of renal denervation in a real world patient population with hypertension. It also aims to gather data for other diseases characterized by elevated sympathetic drive.
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(2015)
Hypertension
, vol.65
, Issue.4
, pp. 766-774
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Bohm, M.1
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Negoita, M.6
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23
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84938347412
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Refractory hypertension: evidence of heightened sympathetic activity as a cause of antihypertensive treatment failure
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COI: 1:CAS:528:DC%2BC2MXpslGgsLg%3D, PID: 25987662
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Dudenbostel T, Acelajado MC, Pisoni R, Li P, Oparil S, Calhoun DA. Refractory hypertension: evidence of heightened sympathetic activity as a cause of antihypertensive treatment failure. Hypertension. 2015;66(1):126–33.
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Hypertension
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Li, P.4
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Calhoun, D.A.6
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24
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84924755264
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Medication adherence and resistant hypertension
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Hyman DJ, Pavlik V. Medication adherence and resistant hypertension. J Hum Hypertens. 2015;29(4):213–8.
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J Hum Hypertens
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Hyman, D.J.1
Pavlik, V.2
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25
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84957843588
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Renal sympathetic denervation by CT-guided ethanol injection: a phase II pilot trial of a novel technique
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COI: 1:STN:280:DC%2BC28vnslWgsQ%3D%3D, PID: 26634740
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Ricke J, Seidensticker M, Becker S, Schiefer J, Adamchic I, Lohfink K, et al. Renal sympathetic denervation by CT-guided ethanol injection: a phase II pilot trial of a novel technique. Cardiovasc Intervent Radiol. 2016;39(2):251–60.
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Cardiovasc Intervent Radiol
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Ricke, J.1
Seidensticker, M.2
Becker, S.3
Schiefer, J.4
Adamchic, I.5
Lohfink, K.6
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