Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation

Journal of the American College of Cardiology

Volumn 66, Issue 16, 2015, Pages 1766-1775

  Mahfoud, Felix ^a   Tunev, Stefan ^b   Ewen, Sebastian ^a   Cremers, Bodo ^a   Ruwart, Jennifer ^b   Schulz Jander, Daniel ^b   Linz, Dominik ^a   Davies, Justin ^c   Kandzari, David E ^d   Whitbourn, Robert ^e   Böhm, Michael ^a   Melder, Robert J ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b MEDTRONIC INC   (United States)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d PIEDMONT HEART INSTITUTE   (United States)

^e ST VINCENT S HOSPITAL   (Australia)

Author keywords

branch treatment; optimized techniques; resistant hypertension

Indexed keywords

NORADRENALIN;

ABLATION CATHETER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LESION; ARTICLE; CATHETER ABLATION; CELL DENSITY; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; KIDNEY CORTEX; KIDNEY DENERVATION; MALE; NERVE FIBER; NONHUMAN; PIG; PRIORITY JOURNAL; SAFETY; TREATMENT RESPONSE; ANIMAL; CELL COUNT; DENERVATION; FEMALE; INNERVATION; KIDNEY; KIDNEY ARTERY; PROCEDURES; SURGERY;

ANIMALS; AXONS; CATHETER ABLATION; CELL COUNT; DENERVATION; FEMALE; KIDNEY; MALE; RENAL ARTERY; SWINE;

EID: 84944037367     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.08.018     Document Type: Article

References (31)

1. M. Böhm, D. Linz, C. Ukena, M. Esler, and F. Mahfoud Renal denervation for the treatment of cardiovascular high risk-hypertension or beyond? Circ Res 115 2014 400 409
2. F. Mahfoud, T.F. Lüscher, B. Andersson, and et al. Expert consensus document from the European Society of Cardiology on catheter-based renal denervation Eur Heart J 34 2013 2149 2157
3. F. Mahfoud, M. Böhm, M. Azizi, and et al. Proceedings from the European Clinical Consensus Conference for Renal Denervation: considerations on future clinical trial design Eur Heart J 36 2015 2219 2227
4. G.F. DiBona Physiology in perspective: the wisdom of the body. Neural control of the kidney Am J Physiol Regul Integr Comp Physiol 289 2005 R633 R641
5. M. Esler The sympathetic system and hypertension Am J Hypertens 13 2000 99S 105S
6. M. Esler The 2009 Carl Ludwig Lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management J Appl Physiol 108 2010 227 237
7. F. Mahfoud, and T.F. Lüscher Renal denervation: symply trapped by complexity? Eur Heart J 36 2015 199 202
8. M.D. Esler, H. Krum, P.A. Sobotka, and et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (the SYMPLICITY HTN-2 trial): a randomised controlled trial Lancet 376 2010 1903 1909
9. M. Azizi, M. Sapoval, P. Gosse, and et al. Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial Lancet 385 2015 1957 1965
10. S. Desch, T. Okon, D. Heinemann, and et al. Randomized sham-controlled trial of renal sympathetic denervation in mild resistant hypertension Hypertension 65 2015 1202 1208
11. D.L. Bhatt, D.E. Kandzari, W.W. O'Neill, and et al. A controlled trial of renal denervation for resistant hypertension N Engl J Med 370 2014 1393 1401
12. D.E. Kandzari, D.L. Bhatt, S. Brar, and et al. Predictors of blood pressure response in the SYMPLICITY HTN-3 trial Eur Heart J 36 2015 219 227
13. T.F. Lüscher, and F. Mahfoud Renal nerve ablation after SYMPLICITY HTN-3: confused at the higher level? Eur Heart J 35 2014 1706 1711
14. C.S. Zuern, C. Eick, K.D. Rizas, and et al. Impaired cardiac baroreflex sensitivity predicts response to renal sympathetic denervation in patients with resistant hypertension J Am Coll Cardiol 62 2013 2124 2130
15. P. Gal, M.R. de Jong, J.J. Smit, and et al. Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study J Hum Hypertens 29 2015 292 295
16. M. Esler Illusions of truths in the SYMPLICITY HTN-3 trial: generic design strengths but neuroscience failings J Am Soc Hypertens 8 2014 593 598
17. F. Mahfoud, E.R. Edelman, and M. Böhm Catheter-based renal denervation is no simple matter: lessons to be learned from our anatomy? J Am Coll Cardiol 64 2014 644 646
18. K. Sakakura, E. Ladich, Q. Cheng, and et al. Anatomic assessment of sympathetic peri-arterial renal nerves in man J Am Coll Cardiol 64 2014 635 643
19. A.R. Tzafriri, F. Mahfoud, J.H. Keating, and et al. Innervation patterns may limit response to endovascular renal denervation J Am Coll Cardiol 64 2014 1079 1087
20. J.R. Henegar, Y. Zhang, C. Hata, I. Narciso, M.E. Hall, and J.E. Hall Catheter-based radiofrequency renal denervation: location effects on renal norepinephrine Am J Hypertens 28 2015 909 914
21. F. Mahfoud, S. Tunev, J. Ruwart, and et al. Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries Circ Cardiovasc Interv 7 2014 813 820
22. H. Krum, M.P. Schlaich, P.A. Sobotka, and et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the SYMPLICITY HTN-1 study Lancet 383 2014 622 629
23. J. Rosa, P. Widimsky, P. Tousek, and et al. Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study Hypertension 65 2015 407 413
24. F. Mahfoud, C. Ukena, R.E. Schmieder, and et al. Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension Circulation 128 2013 132 140
25. A. Persu, Y. Jin, M. Azizi, and et al. Blood pressure changes after renal denervation at 10 European expert centers J Hum Hypertens 28 2014 150 156
26. H. Krum, M. Schlaich, R. Whitbourn, and et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study Lancet 373 2009 1275 1281
27. D. Linz, A. van Hunnik, M. Hohl, and et al. Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats Circ Arrhythm Electrophysiol 8 2015 466 474
28. E.E. Vink, R. Goldschmeding, A. Vink, and et al. Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study Nephrol Dial Transplant 29 2014 1608 1610
29. M. Böhm, F. Mahfoud, C. Ukena, and et al. First report of the global SYMPLICITY registry on the effect of renal artery denervation in patients with uncontrolled hypertension Hypertension 65 2015 766 774
30. A. Persu, M. Sapoval, M. Azizi, and et al. Renal artery stenosis following renal denervation: a matter of concern J Hypertens 32 2014 2101 2105
31. L.C. Booth, E.E. Nishi, S.T. Yao, and et al. Reinnervation of renal afferent and efferent nerves at 5.5 and 11 months after catheter-based radiofrequency renal denervation in sheep Hypertension 65 2015 393 400