Anti-VEGF PolysiRNA Polyplex for the Treatment of Choroidal Neovascularization

Molecular Pharmaceutics

Volumn 13, Issue 6, 2016, Pages 1988-1995

  Lee, Jihwang ^a   Ryoo, Na Kyung ^b,c   Han, Hyounkoo ^a   Hong, Hye Kyoung ^b   Park, Ji Yeon ^b   Park, Sang Jun ^b,c   Kim, Yong Kyu ^b,c   Sim, Changbeom ^a   Kim, Kwangmeyung ^d   Woo, Se Joon ^b,c   Park, Kyu Hyung ^b,c   Kim, Hyuncheol ^a  

^a Sogang University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

choroidal neovascularization; intravitreal injection; polyplex; polysiRNA

Indexed keywords

MESSENGER RNA; NANOCARRIER; SMALL INTERFERING RNA; VASCULOTROPIN ANTIBODY; HYALURONIC ACID; POLYETHYLENEIMINE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL MEMBRANE; CHOROID; CONTROLLED STUDY; DRUG EFFICACY; DRUG UPTAKE; GENE DELIVERY SYSTEM; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; RETINA; RNA TRANSLATION; RNAI THERAPEUTICS; SUBRETINAL NEOVASCULARIZATION; VITREOUS BODY; ZETA POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMISTRY; CHOROIDAL NEOVASCULARIZATION; DISEASE MODEL; DRUG EFFECTS; EXPERIMENTAL MELANOMA; HUMAN; INTRAVITREAL DRUG ADMINISTRATION; MACULAR DEGENERATION; METABOLISM; PROCEDURES; TISSUE DISTRIBUTION;

ANIMALS; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; HUMANS; HYALURONIC ACID; INTRAVITREAL INJECTIONS; MACULAR DEGENERATION; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; POLYETHYLENEIMINE; RETINA; RNA, MESSENGER; RNA, SMALL INTERFERING; RNAI THERAPEUTICS; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84973650214     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00148     Document Type: Article

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