In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation

Transfusion Medicine and Hemotherapy

Volumn 43, Issue 3, 2016, Pages 190-197

  Johnson, Lacey ^a   Hyland, Ryan ^a   Tan, Shereen ^a   Tolksdorf, Frank ^b   Sumian, Chryslain ^c   Seltsam, Axel ^d   Marks, Denese ^a  

^a AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

^b MacoPharma International GmbH   (Germany)

^c MacoPharma   (France)

^d Institute Springe   (Germany)

Author keywords

Pathogen inactivation; Plasma carryover; Platelet concentrates; UVC

Indexed keywords

BETA3 INTEGRIN; CD47 ANTIGEN; CD63 ANTIGEN; FIBRINOGEN RECEPTOR; GLUCOSE; GLYCOPROTEIN IB ALPHA; LACTIC ACID; PADGEM PROTEIN; PHOSPHATIDYLSERINE;

ARTICLE; BLOOD COMPONENT; CLINICAL ASSESSMENT; COMPARATIVE STUDY; GLUCOSE INTAKE; HUMAN; HYPOTONIC SHOCK RESPONSE; IN VITRO STUDY; PATHOGENESIS; PLASMA; PLASMA CARRYOVER; PLATELET MICROPARTICLE; SHOCK; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE METABOLISM; THROMBOCYTE PRESERVATION; THROMBOELASTOGRAPHY; ULTRAVIOLET C RADIATION;

EID: 84973474076     PISSN: 16603796     EISSN: 16603818     Source Type: Journal    
DOI: 10.1159/000441830     Document Type: Article

References (31)

1. Schlenke P: Pathogen inactivation technologies for cellular blood components: an update. Transfus Med Hemother 2014; 41: 309-325.
2. Chin S, Williams B, Gottlieb P, Margolis-Nunno H, Ben-Hur E, Hamman J, Jin R, Dubovi E, Horowitz B: Virucidal short wavelength ultraviolet light treatment of plasma and factor viii concentrate: protection of proteins by antioxidants. Blood 1995; 86: 4331-4336.
3. Gomes AA, Silva-Junior AC, Oliveira EB, Asad LM, Reis NC, Felzenszwalb I, Kovary K, Asad NR: Reactive oxygen species mediate lethality induced by far-UV in Escherichia coli cells. Redox Rep 2005; 10: 91-95.
4. Mohr H, Steil L, Gravemann U, Thiele T, Hammer E, Greinacher A, Muller TH, Volker U: A novel approach to pathogen reduction in platelet concentrates using short-wave ultraviolet light. Transfusion 2009; 49: 2612-2624.
5. Bashir S, Cookson P, Wiltshire M, Hawkins L, Sonoda L, Thomas S, Seltsam A, Tolksdorf F, Williamson LM, Cardigan R: Pathogen inactivation of platelets using ultraviolet C light: effect on in vitro function and recovery and survival of platelets. Transfusion 2013; 53: 990-1000.
6. Mohr H, Gravemann U, Bayer A, Muller TH: Sterilization of platelet concentrates at production scale by irradiation with short-wave ultraviolet light. Transfusion 2009; 49: 1956-1963.
7. Sandgren P, Tolksdorf F, Struff WG, Gulliksson H: In-vitro quality of platelet concentrates treated with short-wave ultraviolet light. Transfusion 2010; 50 (suppl):66A.
8. Tynngard N, Trinks M, Berlin G: In vitro function of platelets treated with ultraviolet C light for pathogen inactivation: a comparative study with nonirradiated and gamma-irradiated platelets. Transfusion 2015; 55: 1169-1177.
9. Johnson L, Loh YS, Kwok M, Marks DC: In vitro assessment of buffy-coat derived platelet components suspended in SSP+ treated with the Intercept Blood System. Transfus Med 2013; 23: 121-129.
10. Picker SM, Oustianskaia L, Schneider V, Gathof BS: Functional characteristics of apheresis-derived platelets treated with ultraviolet light combined with either amotosalen-HCl (S-59) or riboflavin (vitamin B2) for pathogen-reduction. Vox Sang 2009; 97: 26-33.
11. Johnson L, Winter KM, Reid S, Hartkopf-Theis T, Marschner S, Goodrich RP, Marks DC: The effect of pathogen reduction technology (Mirasol) on platelet quality when treated in additive solution with low plasma carryover. Vox Sang 2011; 101: 208-214.
12. Thiele T, Pohler P, Kohlmann T, Sumnig A, Aurich K, Selleng K, Westphal A, Bakchoul T, Petersmann A, Muller TH, Greinacher A, Seltsam A: Tolerance of platelet concentrates treated with UVC-light only for pathogen reduction-a phase I clinical trial. Vox Sang 2015; 109: 44-51.
13. Johnson L, Coorey CP, Marks DC: The hemostatic activity of cryopreserved platelets is mediated by phosphatidylserine-expressing platelets and platelet microparticles. Transfusion 2014; 54: 1917-1926.
14. Seghatchian J, Tolksdorf F: Characteristics of the THERAFLEX UV-platelets pathogen inactivation system-an update. Transfus Apher Sci 2012; 46: 221-229.
15. Johnson L, Winter KM, Hartkopf-Theis T, Reid S, Kwok M, Marks DC: Evaluation of the automated collection and extended storage of apheresis platelets in additive solution. Transfusion 2012; 52: 503-509.
16. Seltsam A, Muller TH: UVC irradiation for pathogen reduction of platelet concentrates and plasma. Transfus Med Hemother 2011; 38: 43-54.
17. Sandgren P, Tolksdorf F, Struff WG, Gulliksson H: In vitro effects on platelets irradiated with short-wave ultraviolet light without any additional photoactive reagent using the THERAFLEX UV-platelets method. Vox Sang 2011; 101: 35-43.
18. Dijkstra-Tiekstra MJ, Kuipers W, Setroikromo AC, Wildt-Eggen JD: Platelet capacity of various platelet pooling systems for buffy coat-derived platelet concentrates. Transfusion 2008; 48: 2114-2121.
19. Goodrich RP, Li J, Pieters H, Crookes R, Roodt J, Heyns Adu P: Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects. Vox Sang 2006; 90: 279-285.
20. van der Meer PF, Kerkhoffs JL, Curvers J, Scharenberg J, de Korte D, Brand A, de Wildt-Eggen J: In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an in vitro rating system. Vox Sang 2010; 98: 517-524.
21. Holme S, Moroff G, Murphy S: A multi-laboratory evaluation of in vitro platelet assays: the tests for extent of shape change and response to hypotonic shock. Biomedical Excellence for Safer Transfusion Working Party of the International Society of Blood Transfusion. Transfusion 1998; 38: 31-40.
22. Verhaar R, Dekkers DW, De Cuyper IM, Ginsberg MH, de Korte D, Verhoeven AJ: UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood 2008; 112: 4935-4939.
23. Zhi L, Chi X, Vostal JG: In vitro and in vivo characterization of ultraviolet light C-irradiated human platelets in a 2 event mouse model of transfusion. PLoS One 2013; 8:e79869.
24. Van Aelst B, Devloo R, Vandekerckhove P, Compernolle V, Feys HB: Ultraviolet C light pathogen inactivation treatment of platelet concentrates preserves integrin activation but affects thrombus formation kinetics on collagen in vitro. Transfusion 2015; 55: 2404-2414.
25. Keuren JF, Magdeleyns EJ, Govers-Riemslag JW, Lindhout T, Curvers J: Effects of storage-induced platelet microparticles on the initiation and propagation phase of blood coagulation. Br J Haematol 2006; 134: 307-313.
26. Maslanka K, Uhrynowska M, Lopacz P, Wrobel A, Smolenska-Sym G, Guz K, Lachert E, Ostas A, Brojer E: Analysis of leucocyte antibodies, cytokines, lysophospholipids and cell microparticles in blood components implicated in post-transfusion reactions with dyspnoea. Vox Sang 2015; 108: 27-36.
27. Pohler P, Muller M, Winkler C, Schaudien D, Sewald K, Muller TH, Seltsam A: Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products. Transfusion 2015; 55: 337-347.
28. Castro E, Girones N, Guerrero N, Barea L, Fresno M: The effectiveness of UVC pathogen inactivation system on reducing the Trypanosoma cruzi and Leishmania infantum burden in platelets. Vox Sang 2008; 95(suppl 1):290.
29. Castro E, Gonzalez LM, Rubio JM, Ramiro R, Girones N, Montero E: The efficacy of the ultraviolet C pathogen inactivation system in the reduction of Babesia divergens in pooled buffy coat platelets. Transfusion 2014; 54: 2207-2216.
30. Steinmann E, Gravemann U, Friesland M, Doerrbecker J, Muller TH, Pietschmann T, Seltsam A: Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products. Transfusion 2013; 53: 1010-1018.
31. Seed CR, Kiely P, Keller AJ: Residual risk of transfusion transmitted human immunodeficiency virus, hepatitis B virus, hepatitis C virus and human T lymphotrophic virus. Intern Med J 2005; 35: 592-598.