In vitro effects on platelets irradiated with short-wave ultraviolet light without any additional photoactive reagent using the THERAFLEX UV-Platelets method

Vox Sanguinis

Volumn 101, Issue 1, 2011, Pages 35-43

  Sandgren, P ^a   Tolksdorf, F ^b   Struff, W G ^b   Gulliksson, H ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MacoPharma International GmbH   (Germany)

Author keywords

Additive solutions; Platelets; Storage

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTATE DEHYDROGENASE;

ARTICLE; BLOOD PH; BLOOD STORAGE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INTERMETHOD COMPARISON; LACTATE DEHYDROGENASE BLOOD LEVEL; MICROORGANISM DETECTION; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE LIFESPAN; THROMBOCYTE SHAPE; ULTRAVIOLET RADIATION;

ADENOSINE TRIPHOSPHATE; BACTERIA; BLOOD PLATELETS; BLOOD PRESERVATION; GLUCOSE; HUMANS; INTEGRIN BETA3; L-LACTATE DEHYDROGENASE; LACTIC ACID; P-SELECTIN; PLATELET COUNT; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET MEMBRANE GLYCOPROTEIN IIB; ULTRAVIOLET RAYS;

EID: 79958844447     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2010.01454.x     Document Type: Article

References (45)

1. Blajchman MA: Protecting the blood supply from emerging pathogens: the role of pathogen inactivation. Transfus Clin Biol 2009; 16:70-74
2. Blajchman MA, Goldman M, Baeza F: Improving the bacteriological safety of platelet transfusions. Transfus Med Rev 2004; 18:11-24
3. Yomtovian R, Lazarus HM, Goodnough LT, et al.: A prospective microbiologic surveillance program to detect and prevent the transfusion of bacterially contaminated platelets. Transfusion 1993; 33:902-909
4. Burstain JM, Brecher ME, Workman K, et al.: Rapid identification of bacterially contaminated platelets using reagent strips: glucose and pH analysis as markers of bacterial metabolism. Transfusion 1997; 37:255-258
5. Wagner SJ, Robinette D: Evaluation of swirling, pH, and glucose tests for the detection of bacterial contamination in platelet concentrates. Transfusion 1996; 12:989-993
6. de Korte D, Curvers J, de Kort WL, et al.: Effects of skin disinfection method, deviation bag, and bacterial screening on clinical safety of platelet transfusions in the Netherlands. Transfusion 2006; 46:476-485
7. Larsen CP, Ezligini F, Hermansen NO, et al.: Six years' experience of using the BacT/ALERT system to screen all platelet concentrates, and additional testing of outdated platelet concentrates to estimate the frequency of false-negative results. Vox Sang 2005; 88:93-97
8. Brecher ME, Hay SN: Bacterial contamination of blood components. Clin Microbiol Rev 2005; 18:195-204
9. Ortolano GA, Freundlich LF, Holme S, et al.: Detection of bacteria in WBC-reduced PLT concentrates using percent oxygen as a marker for bacteria growth. Transfusion 2003; 43:1276-1285
10. Rock G, Neurath D, Toye B, et al.: The use of a bacteria detection system to evaluate bacterial contamination in PLT concentrates. Transfusion 2004; 44:337-342
11. Sandgren P, Hansson M, Gulliksson H, et al.: Storage of buffy-coat-derived platelets in additive solutions at 4 degrees C and 22 degrees C: flow cytometry analysis of platelet glycoprotein expression. Vox Sang 2007; 93:27-36
12. Sandgren P, Shanwell A, Gulliksson H: Storage of buffy coat-derived platelets in additive solutions: in vitro effects of storage at 4 degrees C. Transfusion 2006; 46:828-834
13. Rumjantseva V, Grewal PK, Wandall HH, et al.: Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med 2009; 15:1273-1280
14. Wandall HH, Hoffmeister KM, Sorensen AL, et al.: Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets. Blood 2008; 111:3249-3256
15. Lin L, Dikeman R, Molini B, et al.: Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. Transfusion 2004; 44:1496-1504
16. Goodrich RP, Edrich RA, Li J, et al.: The Mirasol PRT system for pathogen reduction of platelets and plasma: an overview of current status and future trends. Transfus Apher Sci 2006; 35:5-17
17. Ciaravi V, McCullough T, Dayan AD: Pharmacokinetic and toxicology assessment of INTERCEPT (S-59 and UVA treated) platelets. Hum Exp Toxicol 2001; 20:533-550
18. Ciaravino V, McCullough T, Cimino G, et al.: Preclinical safety profile of plasma prepared using the INTERCEPT Blood System. Vox Sang 2003; 85:171-182
19. Mohr H, Gravemann U, Bayer A, et al.: Sterilization of platelet concentrates at production scale by irradiation with short-wave ultraviolet light. Transfusion 2009; 49:1956-1963
20. Mohr H, Steil L, Gravemann U, et al.: A novel approach to pathogen reduction in platelet concentrates using short-wave ultraviolet light. Transfusion 2009; 49:2612-2624
21. Kallenbach NR, Cornelius PA, Negus D, et al.: Inactivation of viruses by ultraviolet light. Curr Stud Hematol Blood Transfus 1989; 56:70-82
22. Sinha RP, Hader DP: UV-induced DNA damage and repair: a review. Photochem Photobiol Sci 2002; 1:225-236
23. Verhaar R, Dekkers DW, De Cuyper IM, et al.: UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood 2008; 112:4935-4939
24. Zimmerman GA, Weyrich AS: Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol 2008; 28:s17-s24
25. Kieffer N, Guichard J, Farcet JP, et al.: Biosynthesis of major platelet proteins in human blood platelets. Eur J Biochem 1987; 164:189-195
26. Denis MM, Tolley ND, Bunting M, et al.: Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005; 122:379-391
27. Weyrich AS, Dixon DA, Pabla R, et al.: Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A 1998; 95:5556-5561
28. Kannan M, Mohan KV, Kulkarni S, et al.: Membrane array-based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis. Transfusion 2009; 49:1443-1450
29. Larsson S, Sandgren P, Sjodin A, et al.: Automated preparation of platelet concentrates from pooled buffy coats: in vitro studies and experiences with the OrbiSac system. Transfusion 2005; 45:743-751
30. Mohr H, Walker W, Muller TH: Polyolefinacetate bags for photodynamic treatment and for storage pf platelet concentrates. Vox Sang 2004;87(Suppl. 3):S17-S92.
31. Bertolini F, Murphy S: A multicenter inspection of the swirling phenomenon in platelet concentrates prepared in routine practice. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion. Transfusion 1996; 36:128-132
32. Moroff G, Eich J, Dabay M: Validation of use of the Nageotte hemocytometer to count low levels of white cells in white cell-reduced platelet components. Transfusion 1994; 34:35-38
33. VandenBroeke T, Dumont LJ, Hunter S, et al.: Platelet storage solution affects on the accuracy of laboratory tests for platelet function: a multi-laboratory study. Vox Sang 2004; 86:183-188
34. Lundin A: Use of firefly luciferase in ATP-related assays of biomass, enzymes, and metabolites. Methods Enzymol 2000; 305:346-370
35. King J: A routine method for the estimation of lactic dehydrogenase activity. J Med Lab Technol 1959; 16:265-272
36. Kilkson H, Holme S, Murphy S: Platelet metabolism during storage of platelet concentrates at 22 degrees C. Blood 1984; 64:406-414
37. Holme S, Heaton WA, Courtright M: Platelet storage lesion in second-generation containers: correlation with platelet ATP levels. Vox Sang 1987; 53:214-220
38. Picker SM, Steisel A, Gathof BS: Cell integrity and mitochondrial function after Mirasol-PRT treatment for pathogen reduction of apheresis-derived platelets: results of a three-arm in vitro study. Transfus Apher Sci 2009; 40:79-85
39. Holme S: Storage and quality assessment of platelets. Vox Sang 1998; 74(Suppl. 2):207-216
40. Keuren JF, Cauwenberghs S, Heeremans J, et al.: Platelet ADP response deteriorates in synthetic storage media. Transfusion 2006; 46:204-212
41. Berndt MC, Shen Y, Dopheide SM, et al.: The vascular biology of the glycoprotein Ib-IX-V complex. Thromb Haemost 2001; 86:178-188
42. Bolin RB, Medina F, Cheney BA: Glycoprotein changes in fresh vs. room temperature-stored platelets and their buoyant density cohorts. J Lab Clin Med 1981; 98:500-510
43. Lozano ML, Rivera J, Gonzalez-Conejero R, et al.: Loss of high-affinity thrombin receptors during platelet concentrate storage impairs the reactivity of platelets to thrombin. Transfusion 1997; 37:368-375
44. McEver RP, Bennett EM, Martin MN: Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem 1983; 258:5269-5275
45. Shattil SJ, Hoxie JA, Cunningham M, et al.: Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem 1985; 260:11107-11114