Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells

Molecular Medicine Reports

Volumn 14, Issue 1, 2016, Pages 394-398

  Fu, Yunfeng ^a   Zhang, Yanan ^a   Gao, Meng ^a   Quan, Lingli ^b   Gui, Rong ^a   Liu, Jing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b ZHUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Akt; Alisertib; Autophagy; Leukemic cells; Mammalian target of rapamycin

Indexed keywords

ACID PHOSPHATASE; ADENYLATE KINASE; ALISERTIB; LIPOCORTIN 5; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPIDIUM IODIDE; PROTEIN KINASE B; AZEPINE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ASSESSMENT; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL; LIGHT CHAIN; MOLECULAR BIOLOGY; MTT ASSAY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; LEUKEMIA; METABOLISM; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; AUTOPHAGY; AZEPINES; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LEUKEMIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84973446468     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5249     Document Type: Article

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