Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology

Glycobiology

Volumn 26, Issue 6, 2016, Pages 560-570

  Sackstein, Robert ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Harvard Skin Disease Research Center   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cell migration; exofucosylation; fucosyltransferase; hematopoietic stem cell; mesenchymal stem cell

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOCONJUGATE; GLYCOSYLTRANSFERASE; HEMATOPOIETIC CELL E L SELETIN LIGAND; HERMES ANTIGEN; HOMING RECEPTOR; L SELECTIN; UNCLASSIFIED DRUG; CD44 PROTEIN, HUMAN; HEMATOPOIETIC CELL E- AND L-SELECTIN LIGAND, HUMAN; HYALURONIC ACID BINDING PROTEIN; SELE PROTEIN, HUMAN;

CELL HOMING; CELL MIGRATION; CELL SURFACE; GLYCOBIOLOGY; HEMATOPOIETIC STEM CELL; HUMAN; INFLAMMATION; MESENCHYMAL STEM CELL; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TRANSLATIONAL GLYCOBIOLOGY; ANIMAL; BONE MARROW CELL; CELL MOTION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HISTORY; IMMUNOLOGY; MESENCHYMAL STROMA CELL; PROCEDURES; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH; TRENDS;

ANIMALS; BONE MARROW CELLS; CELL MOVEMENT; E-SELECTIN; GENE EXPRESSION REGULATION; GLYCOMICS; GLYCOSYLTRANSFERASES; HEMATOPOIETIC STEM CELLS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; HYALURONAN RECEPTORS; MESENCHYMAL STROMAL CELLS; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84973370455     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cww026     Document Type: Review

References (83)

1. Abdi R, Moore R, Sakai S, Donnelly CB, Mounayar M, Sackstein R. 2015. HCELL expression on murine MSC licenses pancreatotropism and confers durable reversal of autoimmune diabetes in NOD mice. Stem Cells. 33:1523-1531.
2. Aizawa S, Tavassoli M. 1987. In vitro homing of hemopoietic stem cells is mediated by a recognition system with galactosyl and mannosyl specificities. Proc Natl Acad Sci USA. 84:4485-4489.
3. Alon R, Chen S, Puri KD, Finger EB, Springer TA. 1997. The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling. J Cell Biol. 138:1169-1180.
4. Baumheter S, Singer MS, Henzel W, Hemmerich S, Renz M, Rosen SD, Lasky LA. 1993. Binding of L-selectin to the vascular sialomucin CD34. Science. 262:436-438.
5. Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL. 1991. A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J Biol Chem. 266:14869-14872.
6. Berg EL, Yoshino T, Rott LS, Robinson MK, Warnock RA, Kishimoto TK, Picker LJ, Butcher EC. 1991. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cellleukocyte adhesion molecule 1. J Exp Med. 174:1461-1466.
7. Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, et al. 1991. Selectins: A family of adhesion receptors. Cell. 67:233.
8. Bevilacqua MP, Nelson RM. 1993. Selectins. J Clin Invest. 91:379-387.
9. Bevilacqua MP, Stengelin S, Gimbrone MA Jr., Seed B. 1989. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 243: 1160-1165.
10. Butcher EC. 1991. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity. Cell. 67:1033-1036.
11. Carlow DA, Gossens K, Naus S, Veerman KM, Seo W, Ziltener HJ. 2009. PSGL-1 function in immunity and steady state homeostasis. Immunol Rev. 230:75-96.
12. Chin YH, Carey GD, Woodruff JJ. 1983. Lymphocyte recognition of lymph node high endothelium. V. Isolation of adhesion molecules from lysates of rat lymphocytes. J Immunol. 131:1368-1374.
13. Chin YH, Rasmussen R, Cakiroglu AG,Woodruff JJ. 1984. Lymphocyte recognition of lymph node high endothelium. VI. Evidence of distinct structures mediating binding to high endothelial cells of lymph nodes and Peyer's patches. J Immunol. 133:2961-2965.
14. Chin YH, Sackstein R, Cai JP. 1991. Lymphocyte-homing receptors and preferential migration pathways. Proceedings of the Society for Experimental Biology and Medicine. Soc Exp Biol Med. 196:374-380.
15. Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC. 2004. E-selectin, thymusand activation-regulated chemokine/CCL17, intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: A foundation for a cutaneous immunosurveillance system. J Immunol. 172: 1575-1581.
16. Cohnheim J. 1889. Lectures on General Pathology: A Handbook for Practitioners and Students. McKee, A.B. (translation). London: New Sydenham Society.
17. Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R. 2000. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci USA. 97:13841-13846.
18. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. 2001a. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 153:1277-1286.
19. Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R. 2001b. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 276:47623-47631.
20. Duijvestijn AM, Horst E, Pals ST, Rouse BN, Steere AC, Picker LJ, Meijer CJ, Butcher EC. 1988. High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol. 130:147-155.
21. Evans AS. 1976. Causation and disease: The Henle-Koch postulates revisited. Yale J Biol Med. 49:175-195.
22. Finger EB, Puri KD, Alon R, Lawrence MB, von Andrian UH, Springer TA. 1996. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature. 379:266-269.
23. Florey HW, Grant LH. 1961. Leucocyte migration from small blood vessels stimulated with ultraviolet light: An electron-microscope study. J Pathol Bacteriol. 82:13-17.
24. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. 1997. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skinhoming T cells. Nature. 389:978-981.
25. Fuhlbrigge RC, King SL, Sackstein R, Kupper TS. 2006. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 107:1421-1426.
26. Gallatin M, St John TP, Siegelman M, Reichert R, Butcher EC, Weissman IL. 1986. Lymphocyte homing receptors. Cell. 44:673-680.
27. GallatinWM,Weissman IL, Butcher EC. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature. 304:30-34.
28. Gesner BM, Ginsburg V. 1964. Effect of glycosidases on the fate of transfused lymphocytes. Proc Natl Acad Sci USA. 52:750-755.
29. Gesner BM, Gowans JL. 1962. The output of lymphocytes from the thoracic duct of unanaesthetized mice. Br J Exp Pathol. 43:424-430.
30. Goldstein LA, Zhou DF, Picker LJ, Minty CN, Bargatze RF, Ding JF, Butcher EC. 1989. A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell. 56:1063-1072.
31. Gowans JL. 1959. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol. 146:54-69.
32. Gowans JL, Knight EJ. 1964. The route of re-circulation of lymphocytes in the rat. Proc R Soc Lond B Biol Sci. 159:257-282.
33. Gunji Y, Nakamura M, Hagiwara T, Hayakawa K, Matsushita H, Osawa H, Nagayoshi K, Nakauchi H, Yanagisawa M, Miura Y, et al. 1992. Expression and function of adhesion molecules on human hematopoietic stem cells: CD34+ LFA-1-cells are more primitive than CD34+ LFA-1+ cells. Blood. 80:429-436.
34. Hardy CL, Tavassoli M. 1988. Homing of hemopoietic stem cells to hemopoietic stroma. Adv Exp Med Biol. 241:129-133.
35. Imai Y, Singer MS, Fennie C, Lasky LA, Rosen SD. 1991. Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J Cell Biol. 113:1213-1221.
36. Jalkanen S, Bargatze RF, de los Toyos J, Butcher EC. 1987. Lymphocyte recognition of high endothelium: Antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol. 105:983-990.
37. Jalkanen ST, Bargatze RF, Herron LR, Butcher EC. 1986. A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man. Eur J Immunol. 16:1195-1202.
38. Jalkanen S, Reichert RA, Gallatin WM, Bargatze RF,Weissman IL, Butcher EC. 1986. Homing receptors and the control of lymphocyte migration. Immunol Rev. 91:39-60.
39. Johnston GI, Cook RG, McEver RP. 1989. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: Sequence similarity to proteins involved in cell adhesion and inflammation. Cell. 56:1033-1044.
40. Jung K, Linse F, Pals ST, Heller R, Moths C, Neumann C. 1997. Adhesion molecules in atopic dermatitis: Patch tests elicited by house dust mite. Contact Dermatitis. 37:163-172.
41. Kansas GS, Dailey MO. 1989. Expression of adhesion structures during B cell development in man. J Immunol. 142:3058-3062.
42. Lawrence MB, Berg EL, Butcher EC, Springer TA. 1995. Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow. Eur J Immunol. 25:1025-1031.
43. Lawrence MB, Kansas GS, Kunkel EJ, Ley K. 1997. Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E). J Cell Biol. 136:717-727.
44. Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, McEver RP. 2010. Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med. 207:2975-2987.
45. Marchesi VT, Florey HW. 1960. Electron micrographic observations on the emigration of leucocytes. Q J Exp Physiol Cogn Med Sci. 45:343-348.
46. Marchesi VT, Gowans JL. 1964. The migration of lymphocytes through the endothelium of venules in lymph nodes: An electron microscope study. Proc R Soc Lond B Biol Sci. 159:283-290.
47. Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R. 2011. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 118:1774-1783.
48. Merzaban JS, Imitola J, Starossom SC, Zhu B, Wang Y, Lee J, Ali AJ, Olah M, Abuelela AF, Khoury SJ, et al. 2015. Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis. Glycobiology. 25:1392-1409.
49. Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, et al. 2008. E-selectin receptors on human leukocytes. Blood. 112:3744-3752.
50. Oxley SM, Sackstein R. 1994. Detection of an L-selectin ligand on a hematopoietic progenitor cell line. Blood. 84:3299-3306.
51. Picker LJ, De los Toyos J, Telen MJ, Haynes BF, Butcher EC. 1989. Monoclonal antibodies against the CD44 [In(Lu)-related p80], Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors. J Immunol. 142:2046-2051.
52. Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, et al. 2005. Neurospherederived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature. 436:266-271.
53. Polley MJ, Phillips ML, Wayner E, Nudelman E, Singhal AK, Hakomori S, Paulson JC. 1991. CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proc Natl Acad Sci USA. 88:6224-6228.
54. Rasmussen RA, Chin YH, Woodruff JJ, Easton TG. 1985. Lymphocyte recognition of lymph node high endothelium. VII. Cell surface proteins involved in adhesion defined by monoclonal anti-HEBFLN (A.11) antibody. J Immunol. 135:19-24.
55. Rosen SD. 2004. Ligands for L-selectin: Homing, inflammation, beyond. Annu Rev Immunol. 22:129-156.
56. Rosen SD, Singer MS, Yednock TA, Stoolman LM. 1985. Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science. 228:1005-1007.
57. Rosen SD, Yednock TA. 1986. Lymphocyte attachment to high endothelial venules during recirculation: A possible role for carbohydrates as recognition determinants. Mol Cell Biochem. 72:153-164.
58. Sackstein R. 1997. Expression of an L-selectin ligand on hematopoietic progenitor cells. Acta Haematol. 97:22-28.
59. Sackstein R. 2004. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Invest Dermatol. 122:1061-1069.
60. Sackstein R. 2005. The lymphocyte homing receptors: Gatekeepers of the multistep paradigm. Curr Opin Hematol. 12:444-450.
61. Sackstein R. 2009. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: Engineering a roadmap for cell migration. Immunol Rev. 230:51-74.
62. Sackstein R. 2010. Directing stem cell trafficking via GPS. Methods Enzymol. 479:93-105.
63. Sackstein R. 2011. The biology of CD44 and HCELL in hematopoiesis: The 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol. 18:239-248.
64. Sackstein R, Dimitroff CJ. 2000. A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood. 96:2765-2774.
65. Sackstein R, Fu L, Allen KL. 1997. A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity. Blood. 89:2773-2781.
66. Sackstein R, Fuhlbrigge R. 2009. Western blot analysis of adhesive interactions under fluid shear conditions: The blot rolling assay. Methods Mol Biol. 536:343-354.
67. Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R. 2008. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med. 14:181-187.
68. Schweitzer KM, Drager AM, van der Valk P, Thijsen SF, Zevenbergen A, Theijsmeijer AP, van der Schoot CE, Langenhuijsen MM. 1996. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol. 148:165-175.
69. Sherrington CS. 1910. Koch's discovery of the plate culture of microorganisms. Nature. 83:458.
70. Siegelman M, Bond MW, Gallatin WM, St John T, Smith HT, Fried VA, Weissman IL. 1986. Cell surface molecule associated with lymphocyte homing is a ubiquitinated branched-chain glycoprotein. Science. 231:823-829.
71. Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luster AD, Scadden DT, Lin CP. 2005. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature. 435:969-973.
72. Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA Jr., Tedder TF. 1991. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol. 147:2565-2573.
73. Springer TA. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:301-314.
74. St John T, Gallatin WM, Siegelman M, Smith HT, Fried VA, Weissman IL. 1986. Expression cloning of a lymphocyte homing receptor cDNA: Ubiquitin is the reactive species. Science. 231:845-850.
75. Stamper HB Jr., Woodruff JJ. 1976. Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J Exp Med. 144:828-833.
76. Stoolman LM, Rosen SD. 1983. Possible role for cell-surface carbohydratebinding molecules in lymphocyte recirculation. J Cell Biol. 96:722-729.
77. Streeter PR, Rouse BT, Butcher EC. 1988. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol. 107:1853-1862.
78. Terstappen LW, Huang S, Picker LJ. 1992. Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow. Blood. 79:666-677.
79. Thankamony SP, Sackstein R. 2011. Enforced hematopoietic cell E-and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells. Proc Natl Acad Sci USA. 108:2258-2263.
80. Weninger W, Ulfman LH, Cheng G, Souchkova N, Quackenbush EJ, Lowe JB, von Andrian UH. 2000. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Immunity. 12:665-676.
81. Woodruff J, Gesner BM. 1968. Lymphocytes: Circulation altered by trypsin. Science. 161:176-178.
82. Yao L, Setiadi H, Xia L, Laszik Z, Taylor FB, McEver RP. 1999. Divergent inducible expression of P-selectin and E-selectin in mice and primates. Blood. 94:3820-3828.
83. Yusuf-Makagiansar H,erson ME, Yakovleva TV, Murray JS, Siahaan TJ. 2002. Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med Res Rev. 22:146-167.