-
1
-
-
0028670125
-
The biology of erbB-2/neu/HER-2 and its role in cancer
-
Hynes NE, Stern DF (1994) The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198:165-184
-
(1994)
Biochim Biophys Acta
, vol.1198
, pp. 165-184
-
-
Hynes, N.E.1
Stern, D.F.2
-
2
-
-
73949090721
-
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review
-
Dawood S, Broglio K, Buzdar AU et al (2010) Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review. J Clin Oncol 28:92-98
-
(2010)
J Clin Oncol
, vol.28
, pp. 92-98
-
-
Dawood, S.1
Broglio, K.2
Buzdar, A.U.3
-
3
-
-
84862250597
-
Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors
-
Galsky MD, Von Hoff DD, Neubauer M et al (2012) Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors. Invest New Drugs 30(2):695-701. doi:10.1007/s10637-010-9541-0
-
(2012)
Invest New Drugs
, vol.30
, Issue.2
, pp. 695-701
-
-
Galsky, M.D.1
Von Hoff, D.D.2
Neubauer, M.3
-
4
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
5
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J et al (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353:1673-1684
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
6
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D et al (2005) Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 23:4247-4250
-
(2005)
J Clin Oncol
, vol.23
, pp. 4247-4250
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
9
-
-
73149115341
-
Lapatinib combined with Letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S, Pippen J, Pvot X et al (2009) Lapatinib combined with Letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 27:5538-5546
-
(2009)
J Clin Oncol
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
Pvot, X.3
-
10
-
-
20244388653
-
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
-
Spector NL, Xia W, Burris H 3rd et al (2005) Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 23:2502-2512
-
(2005)
J Clin Oncol
, vol.23
, pp. 2502-2512
-
-
Spector, N.L.1
Xia, W.2
Burris, H.3
-
11
-
-
77954031486
-
A phase I study of trastuzumab-DM1, a HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2+ metastatic breast cancer
-
Krop I, Beeram M, Modi S et al (2010) A phase I study of trastuzumab-DM1, a HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2+ metastatic breast cancer. J Clin Oncol 28:2698-2704
-
(2010)
J Clin Oncol
, vol.28
, pp. 2698-2704
-
-
Krop, I.1
Beeram, M.2
Modi, S.3
-
12
-
-
0016724870
-
Antimitotic activity of the potent tumor inhibitor maytansine
-
Remillard S, Rebhun LI, Howie GS, Kupchan SM (1975) Antimitotic activity of the potent tumor inhibitor maytansine. Science 189:1002-1005
-
(1975)
Science
, vol.189
, pp. 1002-1005
-
-
Remillard, S.1
Rebhun, L.I.2
Howie, G.S.3
Kupchan, S.M.4
-
14
-
-
33745847797
-
Semisynthetic maytansine analogues for the targeted treatment of cancer
-
Widdison WC et al (2006) Semisynthetic maytansine analogues for the targeted treatment of cancer. J Med Chem 49:4392-4408
-
(2006)
J Med Chem
, vol.49
, pp. 4392-4408
-
-
Widdison, W.C.1
-
15
-
-
85028513708
-
-
South San Francisco, CA, July
-
Data-on-file, Genentech, Inc., South San Francisco, CA, July 2007
-
(2007)
Data-on-file, Genentech, Inc
-
-
-
16
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis-Phillips GD, Li G, Dugger DL (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 6:9280-9290
-
(2008)
Cancer Res
, vol.6
, pp. 9280-9290
-
-
Lewis-Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
18
-
-
78049515807
-
Brentuximab Vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
Younes A, Bartlett NL, Leonard JP et al (2010) Brentuximab Vedotin (SGN-35) for relapsed CD30-positive lymphomas. NEJM 363:1812-1821
-
(2010)
NEJM
, vol.363
, pp. 1812-1821
-
-
Younes, A.1
Bartlett, N.L.2
Leonard, J.P.3
-
19
-
-
9444252957
-
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
-
Austin CD, De Maziere AM, Pisacane PI et al (2004) Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell 15:5268-5282
-
(2004)
Mol Biol Cell
, vol.15
, pp. 5268-5282
-
-
Austin, C.D.1
De Maziere, A.M.2
Pisacane, P.I.3
-
20
-
-
29144496897
-
Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates
-
Austin CD, Wen X, Gazzard L et al (2005) Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates. PNAS 102: 17987-17992
-
(2005)
PNAS
, vol.102
, pp. 17987-17992
-
-
Austin, C.D.1
Wen, X.2
Gazzard, L.3
-
21
-
-
79955866316
-
Metabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): An emphasis on preclinical and clinical catabolism [Poster PIII-72]
-
Shen B-Q, Bumbaca D, Saad O et al (2011) Metabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism [Poster PIII-72]. Clin Pharmacol Ther 89(Suppl 1):S90
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. S90
-
-
Shen, B.-Q.1
Bumbaca, D.2
Saad, O.3
-
22
-
-
79955841046
-
A phase Ib/II trial of trastuzumab-DM1 with per- tuzumab for patients with HER2-positive, locally advanced or metastatic breast cancer: Interim efficacy and safety results [abstract P3-14-01]
-
Dieras V, Harbeck N, Albain K et al (2010) A phase Ib/II trial of trastuzumab-DM1 with per- tuzumab for patients with HER2-positive, locally advanced or metastatic breast cancer: interim efficacy and safety results [abstract P3-14-01]. Cancer Res 70(Suppl 2):291s
-
(2010)
Cancer Res
, vol.70
, pp. 291s
-
-
Dieras, V.1
Harbeck, N.2
Albain, K.3
-
23
-
-
79955825867
-
A dose-escalation study of trastuzumab-DM1 (T-DM1), paclitaxel (T), and pertuzumab (P) in patients with HER2-positive, locally advanced or metastatic breast cancer (MBC) previously treated with a trastuzumab-containing regimen. Abstract P3-14-10
-
Krop IE, Modi S, Elias A et al (2010) A dose-escalation study of trastuzumab-DM1 (T-DM1), paclitaxel (T), and pertuzumab (P) in patients with HER2-positive, locally advanced or metastatic breast cancer (MBC) previously treated with a trastuzumab-containing regimen. Abstract P3-14-10. Cancer Res 70(Suppl 2):295s
-
(2010)
Cancer Res
, vol.70
, pp. 295s
-
-
Krop, I.E.1
Modi, S.2
Elias, A.3
-
24
-
-
65549088301
-
A phase I study of weekly dosing of trastuzumab- DM1 in patients with advanced HER2+ breast cancer
-
abstract 1029
-
Holden SN, Beeram M, Krop IE, et al (2008) A phase I study of weekly dosing of trastuzumab- DM1 in patients with advanced HER2+ breast cancer. J Clin Oncol 26(Suppl): abstract 1029
-
(2008)
J Clin Oncol
, vol.26
-
-
Holden, S.N.1
Beeram, M.2
Krop, I.E.3
-
25
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)- positive breast cancer after prior HER2-directed therapy
-
Burris HA, Rugo HS, Vukelja SA et al (2011) Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)- positive breast cancer after prior HER2-directed therapy. J Clin Oncol 29:398-405
-
(2011)
J Clin Oncol
, vol.29
, pp. 398-405
-
-
Burris, H.A.1
Rugo, H.S.2
Vukelja, S.A.3
-
26
-
-
85028509576
-
-
Presented at 35th ESMO Congress, 8-12 October 2010, Milan, Italy
-
Krop I, LoRusso P, Miller KD, et al (2010) A phase 2 study of the HER2 antibody-drug conjugate trastuzumab-DM1 (T-DM1) in patients (pts) with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab, lapatinib, and chemotherapy [abstract 2770]. Presented at 35th ESMO Congress, 8-12 October 2010, Milan, Italy
-
(2010)
A phase 2 study of the HER2 antibody-drug conjugate trastuzumab-DM1 (T-DM1) in patients (pts) with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab, lapatinib, and chemotherapy [abstract 2770]
-
-
Krop, I.1
LoRusso, P.2
Miller, K.D.3
-
27
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205-216
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
28
-
-
33846568336
-
American Society of Clinical Oncology/ College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
-
Wolff AC, Hammond M, Schwartz J et al (2007) American Society of Clinical Oncology/ College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med 131:18-43
-
(2007)
Arch Pathol Lab Med
, vol.131
, pp. 18-43
-
-
Wolff, A.C.1
Hammond, M.2
Schwartz, J.3
-
29
-
-
25144523389
-
Diagnostic evaluation of HER-2 as a molecular target: An assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials
-
Press MF, Sauter G, Bernstein L et al (2005) Diagnostic evaluation of HER-2 as a molecular target: an assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials. Clin Cancer Res 11:6598-6607
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6598-6607
-
-
Press, M.F.1
Sauter, G.2
Bernstein, L.3
-
30
-
-
79551585669
-
Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC) who had progressed on prior HER2-directed therapy, Abstract 1016
-
LoRusso P et al (2010) Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC) who had progressed on prior HER2-directed therapy, Abstract 1016. J Clin Oncol 28: 15s-118s
-
(2010)
J Clin Oncol
, vol.28
, pp. 15s-118s
-
-
LoRusso, P.1
-
31
-
-
0037440038
-
Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: A phase I, pharmacokinetic, and biologic correlative study
-
Tolcher AW, Ochoa L, Hammond LA et al (2003) Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol 21:211-222
-
(2003)
J Clin Oncol
, vol.21
, pp. 211-222
-
-
Tolcher, A.W.1
Ochoa, L.2
Hammond, L.A.3
-
32
-
-
43849094005
-
Cardiotoxicity profile of trastuzumab
-
Ewer SM, Ewer MS (2008) Cardiotoxicity profile of trastuzumab. Drug Saf 31:459-467
-
(2008)
Drug Saf
, vol.31
, pp. 459-467
-
-
Ewer, S.M.1
Ewer, M.S.2
-
34
-
-
84860307997
-
Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab-DM1, a HER2- targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer
-
Gupta M, LoRusso PM, Wang B et al (2012) Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab-DM1, a HER2- targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer. J Clin Pharm 52(5):691-703
-
(2012)
J Clin Pharm
, vol.52
, Issue.5
, pp. 691-703
-
-
Gupta, M.1
LoRusso, P.M.2
Wang, B.3
-
35
-
-
83255175479
-
Trastuzumab emtansine (T-DM1) versus trastuzumab + docetaxel in previously untreated HER2-positive metastatic breast cancer (MBC): Primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976)
-
Abstract 5001
-
Hurvitz SA, Dirix L, Kocsis J et al (2011) Trastuzumab emtansine (T-DM1) versus trastuzumab + docetaxel in previously untreated HER2-positive metastatic breast cancer (MBC): primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976). ESMO Annual Meeting. Abstract 5001
-
(2011)
ESMO Annual Meeting
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
-
36
-
-
33645452875
-
Cancer symptom assessment instruments: A systematic review
-
Kirkova J, Davis MP, Walsh D et al (2006) Cancer symptom assessment instruments: a systematic review. J Clin Oncol 24:1459-1473
-
(2006)
J Clin Oncol
, vol.24
, pp. 1459-1473
-
-
Kirkova, J.1
Davis, M.P.2
Walsh, D.3
-
37
-
-
79952258750
-
First results of the NeoALTTO trial (BIG 01-06/EGF 106903): A phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer
-
Abstract 291
-
Baselga J et al (2010) First results of the NeoALTTO trial (BIG 01-06/EGF 106903): a phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer. SABCS 2010. Abstract 291
-
(2010)
SABCS 2010
-
-
Baselga, J.1
-
38
-
-
79952274439
-
Neoadjuvant pertuzumab (P) and trastuzumab (H): Antitumor and safety analysis of a randomized phase II study (NeoSphere)
-
Abstract S3-2
-
Gianni L, et al (2010) Neoadjuvant pertuzumab (P) and trastuzumab (H): antitumor and safety analysis of a randomized phase II study (NeoSphere). SABCS 2010. Abstract S3-2.
-
(2010)
SABCS 2010
-
-
Gianni, L.1
-
39
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro- oesophageal junction cancer (ToGA): A phase 3, open-label, randomized controlled trial
-
Bang Y-J, Cutsem EV, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro- oesophageal junction cancer (ToGA): a phase 3, open-label, randomized controlled trial. Lancet 376:687-697
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.-J.1
Cutsem, E.V.2
Feyereislova, A.3
-
40
-
-
65049086136
-
Pharmacokinetics and pharmacogenomics in gastric cancer chemotherapy
-
Nishiyama M, Eguchi H (2009) Pharmacokinetics and pharmacogenomics in gastric cancer chemotherapy. Adv Drug Deliv Rev 61:402-407
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 402-407
-
-
Nishiyama, M.1
Eguchi, H.2
-
41
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K, Horlings HM, Hennessy BT et al (2007) A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12:395-402
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
-
42
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocana A et al (2007) Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. JNCI 99:628-638
-
(2007)
JNCI
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocana, A.3
-
43
-
-
84868520609
-
Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
-
Verma S et al (2012) Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer. N Engl J Med
-
(2012)
N Engl J Med
-
-
Verma, S.1
-
44
-
-
84867571080
-
A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer
-
Bender BC et al (2012) A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Cancer Chemother Pharmacol
-
(2012)
Cancer Chemother Pharmacol
-
-
Bender, B.C.1
-
45
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J et al (2012) Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 366(2):109-119
-
(2012)
N Engl J Med
, vol.366
, Issue.2
, pp. 109-119
-
-
Baselga, J.1
|