Co-location of the oxazolidinone resistance genes optrA and cfr on a multiresistance plasmid from Staphylococcus sciuri

Journal of Antimicrobial Chemotherapy

Volumn 71, Issue 6, 2016, Pages 1474-1478

  Li, Dexi ^a   Wang, Yang ^a   Schwarz, Stefan ^a,b   Cai, Jiachang ^c   Fan, Run ^a   Li, Jun ^a,b   Feßler, Andrea T ^b   Zhang, Rong ^c   Wu, Congming ^a   Shen, Jianzhong ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FLORFENICOL; OXAZOLIDINONE DERIVATIVE; ANTIINFECTIVE AGENT; THIAMPHENICOL;

AADD GENE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; BLE GENE; CFR GENE; FEXA GENE; GENETIC VARIABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTRA GENE; PLASMID; SOUTHERN BLOTTING; STAPHYLOCOCCUS LENTUS; STAPHYLOCOCCUS SCIURI; ANALOGS AND DERIVATIVES; ANALYSIS; ANIMAL; BACTERIUM CONJUGATION; BACTERIUM TRANSFORMATION; DNA SEQUENCE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MOLECULAR CLONING; MULTIDRUG RESISTANCE; PIG; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS;

ANIMALS; ANTI-INFECTIVE AGENTS; CLONING, MOLECULAR; CONJUGATION, GENETIC; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE EXPRESSION; GENES, BACTERIAL; MICROBIAL SENSITIVITY TESTS; OXAZOLIDINONES; PLASMIDS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS; SWINE; THIAMPHENICOL; TRANSFORMATION, BACTERIAL;

EID: 84973316105     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkw040     Document Type: Article

References (20)

1. LaMarre J, Mendes RE, Szal T et al. The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L. Antimicrob Agents Chemother 2013; 57: 1173-9.
2. Kloss P, Xiong L, Shinabarger DL et al. Resistance mutations in 23S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center. J Mol Biol 1999; 294: 93-101.
3. Takaya A, Kimura A, Sato Y et al. Molecular characterization of linezolid-resistant CoNS isolates in Japan. J Antimicrob Chemother 2015; 70: 658-63.
4. Mendes RE, Deshpande LM, Castanheira M et al. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother 2008; 52: 2244-6.
5. Feßler AT, Calvo N, Gutierrez N et al. Cfr-mediated linezolid resistance in methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus associated with clinical infections in humans: two case reports. J Antimicrob Chemother 2014; 69: 268-70.
6. Locke JB, Hilgers M, Shaw KJ. Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother 2009; 53: 5265-74.
7. Long KS, Poehlsgaard J, Kehrenberg C et al. The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. Antimicrob Agents Chemother 2006; 50: 2500-5.
8. Hansen LH, Vester B. A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene. Antimicrob Agents Chemother. 2015; 59: 5841-3.
9. Deshpande LM, Ashcraft DS, Kahn HP et al. Detection of a new cfr-like gene, cfr(B), in Enterococcus faecium isolates recovered fromhuman specimens in the United States as part of the SENTRY Antimicrobial Surveillance Program. Antimicrob Agents Chemother 2015; 59: 6256-61.
10. Rodríguez-Avial I, Culebras E, Betriu C et al. In vitro activity of tedizolid (TR-700) against linezolid -resistant staphylococci. J Antimicrob Chemother 2012; 67: 167-9.
11. Wang Y, Lv Y, Cai J et al. A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin. J Antimicrob Chemother 2015; 70: 2182-90.
12. Cai J, Wang Y, Lv H et al. Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010-2014. Clin Microbiol Infect 2015; 21: 1095.e1-4.
13. Wang Y, ZhangW,Wang J et al. Distribution of the multidrug resistance gene cfr in Staphylococcus species isolates from swine farms in China. Antimicrob Agents Chemother 2012; 56: 1485-90.
14. Liu H, Wang Y, Wu C, Schwarz S et al. A novel phenicol exporter gene, fexB, found in enterococci of animal origin. J Antimicrob Chemother 2012; 67: 322-5.
15. Li D, Wu C, Wang Y et al. Identification of multiresistance gene cfr in methicillin-resistant Staphylococcus aureus from pigs: plasmid location and integration into a staphylococcal cassette chromosome mec complex. Antimicrob Agents Chemother 2015; 59: 3641-4.
16. Barton BM, Harding GP, Zuccarelli AJ. A general method for detecting and sizing large plasmids. Anal Biochem 1995; 226: 235-40.
17. He T, Shen J, Schwarz S et al. Characterization of a genomic island in Stenotrophomonas maltophilia that carries a novel floR gene variant. J Antimicrob Chemother 2015; 70: 1031-6.
18. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals: Third Informational Supplement VET01S-Ed3. CLSI, Wayne, PA, USA, 2015.
19. He T, Wang Y, Schwarz S et al. Genetic environment of the multiresistance gene cfr in methicillin-resistant coagulase-negative staphylococci from chickens, ducks, and pigs in China. Int J Med Microbiol 2014; 304: 257-61.
20. Wang Y,Wang Y, Schwarz S et al. Detection of the staphylococcal multiresistance gene cfr in Macrococcus caseolyticus and Jeotgalicoccus pinnipedialis. J Antimicrob Chemother 2012; 67: 1824-7.