Greater hippocampal volume is associated with PTSD treatment response

Psychiatry Research - Neuroimaging

Volumn 252, Issue , 2016, Pages 36-39

  Rubin, Mikael ^a   Shvil, Erel ^a   Papini, Santiago ^a   Chhetry, Binod T ^a   Helpman, Liat ^a   Markowitz, John C ^a,b   Mann, J John ^a,b   Neria, Yuval ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

Hippocampus; MRI; Prolonged Exposure Treatment; PTSD; Resilience; Treatment Response

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEAR; FEMALE; HAMILTON DEPRESSION RATING SCALE; HIPPOCAMPUS; HUMAN; IMAGING SOFTWARE; LIFE EVENTS CHECKLIST; LIFE EVENTS SCALE; LONG TERM EXPOSURE; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; TREATMENT RESPONSE; CASE CONTROL STUDY; DIAGNOSTIC IMAGING; DRUG EFFECTS; EVALUATION STUDY; MIDDLE AGED; PATHOLOGY; PROCEDURES; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTOR; TREATMENT OUTCOME;

ADULT; CASE-CONTROL STUDIES; FEAR; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS; TREATMENT OUTCOME;

EID: 84973137759     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2016.05.001     Document Type: Article

References (19)

1. Apfel B.A., Ross J., Hlavin J., Meyerhoff D.J., Metzler T.J., Marmar C.R., Weiner M.W., Schuff N., Neylan T.C. Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms. Biol. Psychiatry 2011, 69(6):541-548. 10.1016/j.biopsych.2010.09.044.
2. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Gusman F.D., Charney D.S., Keane T.M. The development of a clinician-administered PTSD scale. J. Trauma. Stress 1995, 8:75-90. 10.1007/BF02105408.
3. Bonne O., Brandes D., Gilboa A., Gomori M., Shenton M.E., Pitman R.K., Shalev A.Y. Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD. Am J Psychiatry 2001, 158(8):1248. PMCID: PMC2819102NIHMSID: NIHMS170397. 10.1176/appi.ajp.158.8.1248.
4. Bossini L, Tavanti M, Calossi S, Polizzotto NR, Vatti G, Marino D, Castrogiovanni P. J. (EMDR treatment for posttraumatic stress disorder, with focus on hippocampal volumes: a pilot study. Neuropsychiatry Clin Neurosci. 2011 PMID: 21677204.
5. Brady K., Pearlstein T., Asnis G.M., Baker D., Rothbaum B., Sikes C.R., Farfel G.M. Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA 2000, 283:1837-1844. 10.1001/jama.283.14.1837.
6. Dale A.M., Fischl B., Sereno M.I. Cortical surface-based analysis - I. Segmentation and surface reconstruction. NeuroImage 1999, 9:179-194. 10.1006/nimg.1998.0395.
7. First M.B., Gibbon M. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II) 2004, John Wiley & Sons, New York.
8. Foa E.B., Hembree E.A., Rothbaum B.O. Prolonged Exposure Therapy for PTSD: Emotional Processing of Traumatic Experiences Therapist Guide 2007, Oxford University Press, New York.
9. Foa E.B., Keane T.M., Friedman M.J., Cohen J.A. Effective treatments for PTSD: Practice guidelines from the International Society for Traumatic Stress Studies 2008, The Guilford Press, New York.
10. Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Lasko N.B., Orr S.P., Pitman R.K. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat. Neurosci. 2002, 5:1242-1247. 10.1038/nn958.
11. Imel Z.E., Laska K., Jakupcak M., Simpson T.L. Meta-analysis of dropout in treatments for posttraumatic stress disorder. J. Consult. Clin. Psychol. 2013, 81:394-404. 10.1037/a0031474.
12. Ji J., Maren S. Hippocampal involvement in contextual modulation of fear extinction. Hippocampus 2007, 17:749-758. 10.1002/hipo.20331.
13. Ji J., Maren S. Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear. Learn. Mem. 2008, 15:244-251. 10.1101/lm.794808.
14. Levy-Gigi E., Szabó C., Kelemen O., Kéri S. Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy. Biol. Psychiatry 2013, 74:793-800. 10.1016/j.biopsych.2013.05.017.
15. Lindauer R.J.L., Vlieger E.-J., Jalink M., et al. Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation. Psychol. Med. 2005, 35:1421-1431. 10.1017/S0033291705005246.
16. Negash S., Kliot D., Howard D.V., Howard J.H., Das S.R., Yushkevich P.A., Pluta J.B., Arnold S.E., Wolk D.A. Relationship of contextual cueing and hippocampal volume in amnestic mild cognitive impairment patients and cognitively normal older adults. J. Int. Neuropsychol. Soc. 2015, 21:285-296. 10.1017/S1355617715000223.
17. Shin L.M. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann. N. Y. Acad. Sci. 2006, 1071:67-79. 10.1196/annals.1364.007.
18. van Rooij S.J.H., Kennis M., Sjouwerman R., van den Heuvel M.P., Kahn R.S., Geuze E. Smaller hippocampal volume as a vulnerability factor for the persistence of post-traumatic stress disorder. Psychol. Med. 2015, 45:2737-2746. 10.1017/S0033291715000707.
19. Vermetten E., Southwick S.M., Charney D.S., Vythilingam M., Bremner J.D. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol. Psychiatry 2003, 54:693-702. 10.1016/S0006-3223(03)00634-6.