Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains

Neuroscience Letters

Volumn 617, Issue , 2016, Pages 188-194

  Rich, Megan C ^a   Keene, Chesleigh N ^a   Neher, Miriam D ^a   Johnson, Krista ^b   Yu, Zhao Xue ^b   Ganivet, Antoine ^a   Holers, V Michael ^a   Stahel, Philip F ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b ALEXION PHARMACEUTICALS   (United States)

Author keywords

CR2 conjugated pharmacological compounds; Neuroinflammation; Secondary brain injury; Site targeted complement inhibition; Traumatic brain injury

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT INHIBITOR; MTT 30; NEUROPROTECTIVE AGENT; PLACEBO; UNCLASSIFIED DRUG; CR2-FH PROTEIN; HYBRID PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSE TITRATION; DRUG TARGETING; EXPERIMENTAL STUDY; HEAD INJURY; IMMUNOHISTOCHEMISTRY; LEFT HEMISPHERE; MALE; MICROGLIA; MOUSE; MOUSE MODEL; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; C57BL MOUSE; CELL DEATH; DRUG EFFECTS; HEAD INJURIES, CLOSED; METABOLISM; NERVE CELL; PATHOLOGY;

ANIMALS; BRAIN; CELL DEATH; COMPLEMENT C3; COMPLEMENT INACTIVATING AGENTS; HEAD INJURIES, CLOSED; MALE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; RECOMBINANT FUSION PROTEINS;

EID: 84973109312     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.02.025     Document Type: Article

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