Elevated Levels of LDL-C are Associated with ApoE4 but Not with the rs688 Polymorphism in the LDLR Gene

Clinical and Applied Thrombosis/Hemostasis

Volumn 22, Issue 5, 2016, Pages 465-470

  Cahua Pablo, Gabriel ^a   Cruz, Miguel ^b   Moral Hernández, Oscar Del ^c   Leyva Vázquez, Marco A ^c   Antúnez Ortiz, Diana L ^b   Cahua Pablo, José A ^a   Alarcón Romero, Luz Del Carmen ^a,c   Ortuño Pineda, Carlos ^a   Moreno Godínez, Ma Elena ^a   Hernández Sotelo, Daniel ^c   Flores Alfaro, Eugenia ^a  

^a UNIVERSIDAD AUTÓNOMA DE GUERRERO   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c Faculty of Mathematics University of Guerrero   (Mexico)

Author keywords

APoE gene; APoE isoforms; LDL C; LDLR gene; triglycerides

Indexed keywords

APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; LDLR PROTEIN, HUMAN;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DOMINANT INHERITANCE; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MEXICO; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; ATHEROSCLEROSIS; GENETICS; HETEROZYGOTE; MIDDLE AGED; ODDS RATIO; UPREGULATION;

ADULT; APOLIPOPROTEIN E4; ATHEROSCLEROSIS; CHOLESTEROL, LDL; FEMALE; HETEROZYGOTE; HUMANS; MEXICO; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LDL; TRIGLYCERIDES; UP-REGULATION;

EID: 84973091472     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029614568714     Document Type: Article

References (28)

1. Mendis S, Puska P, Norrving B, editors. Global Atlas on Cardiovascular Disease Prevention and Control. Geneva: World Health Organization; 2011.
2. Pranavchand R, Reddy BM,. Current status of understanding of the genetic etiology of coronary heart disease. J Postgrad Med. 2013; 59 (1): 30-41.
3. Petkeviciene J, Smalinskiene A, Luksiene DI, et al. Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population. PLoS One. 2012; 7 (7): e41525.
4. Hatters DM, Peters-Libeu CA, Weisgraber KH,. Apolipoprotein E structure: insights into function. Trends Biochem Sci. 2006; 31 (8): 445-454.
5. Hauser PS, Narayanaswami V, Ryan RO,. Apolipoprotein E: from lipid transport to neurobiology. Prog Lipid Res. 2011; 50 (1): 62-74.
6. Gao F, Ihn HE, Medina MW, et al. A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function. Hum Mol Genet. 2013; 22 (7): 1424-1431.
7. Malloy SI, Altenburg MK, Knouff C, et al. Harmful effects of increased LDLR expression in mice with human APOE∗4 but not APOE∗3. Arterioscler Thromb Vasc Biol. 2004; 24 (1): 91-97.
8. Altenburg M, Arbones-Mainar J, Johnson L, et al. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol. 2008; 28 (6): 1104-1110.
9. Tao MH, Liu JW, LaMonte MJ, et al. Different associations of apolipoprotein E polymorphism with metabolic syndrome by sex in an elderly Chinese population. Metabolism. 2011; 60 (10): 1488-1496.
10. Bennet AM, Di Angelantonio E, Ye Z, et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 2007; 298 (11): 1300-1311.
11. Sima A, Iordan A, Stancu C,. Apolipoprotein E polymorphism - a risk factor for metabolic syndrome. Clin Chem Lab Med. 2007; 45 (9): 1149-1153.
12. National Heart Lung and Blood Institute. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): final report. Circulation. 2002; 106 (25): 3143.
13. Lahiri DK, Nurnberger JI,. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991; 19 (19): 5444.
14. Weisgraber KH, Rall SC Jr, Mahley RW, Human E,. apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem. 1981; 256 (17): 9077-9083.
15. Poulson MD, Wittwer CT,. Closed-tube genotyping of apolipoprotein E by isolated-probe PCR with multiple unlabeled probes and high-resolution DNA melting analysis. Biotechniques. 2007; 43 (1): 87-91.
16. National Health Information System (SINAIS). Mortality. 2008. Web site. http://www.sinais.salud.gob.mx/mortalidad/index.html. Accessed January 22, 2014.
17. Schiele F, De Bacquer D, Vincent-Viry M, et al. Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project. Atherosclerosis. 2000; 152 (2): 475-488.
18. Huebbe P, Lodge JK, Rimbach G,. Implications of apolipoprotein E genotype on inflammation and vitamin E status. Mol Nutr Food Res. 2010; 54 (5): 623-630.
19. Volcik KA, Barkley RA, Hutchinson RG, et al. Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants. Am J Epidemiol. 2006; 164 (4): 342-348.
20. Mahfouz RA, Charafeddine KM, Tanios RF, Karaky NM, Abdul Khalik RN, Daher RT,. Apolipoprotein E gene polymorphisms in Lebanese with hypercholesterolemia. Gene. 2013; 522 (1): 84-88.
21. Das M, Pal S, Ghosh A,. Apolipoprotein E gene polymorphism and dyslipidaemia in adult Asian Indians: a population based study from Calcutta, India. Indian J Hum Genet 2008; 14 (3): 87-91.
22. Olivieri O, Martinelli N, Bassi A, et al. ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome. Clin Exp Med. 2007; 7 (4): 164-172.
23. Burman D, Mente A, Hegele RA, Islam S, Yusuf S, Anand SS,. Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada. Atherosclerosis. 2009; 203 (1): 192-200.
24. Katrancioglu N, Manduz S, Ozen F, et al. Association between ApoE4 allele and deep venous thrombosis: a pilot study. Clin Appl Thromb Hemost. 2011; 17 (2): 225-228.
25. Hirashiki A, Yamada Y, Murase Y, et al. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. J Am Coll Cardiol. 2003; 42 (8): 1429-1437.
26. Saito M, Eto M, Nitta H, et al. Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients. Diabetes Care. 2004; 27 (6): 1276-1280.
27. Arbones-Mainar JM, Johnson LA, Altenburg MK, Maeda N,. Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. Int J Obes (Lond). 2008; 32 (10): 1595-1605.
28. Versmissen J, Oosterveer DM, Hoekstra M, et al. Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations. Circ Cardiovasc Genet. 2011; 4 (6): 655-660.