Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

Journal of Neuroscience

Volumn 36, Issue 22, 2016, Pages 6041-6049

  Goeden, Nick ^a   Velasquez, Juan ^a   Arnold, Kathryn A ^b   Chan, Yen ^a   Lund, Brett T ^a   Anderson, George M ^c   Bonnin, Alexandre ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation infection; Neurodevelopment; Placenta; Prenatal programming; Serotonin; Tryptophan

Indexed keywords

CXCL1 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; TUMOR NECROSIS FACTOR ALPHA; 5 HYDROXYTRYPTOPHAN; CYTOKINE; FENCLONINE; POLY D(I-C); POLYDEOXYRIBONUCLEOTIDE; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FOREBRAIN; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NERVE CELL DIFFERENTIATION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHOMBENCEPHALON; SPECTROPHOTOMETRY; ANIMAL; BIOSYNTHESIS; BRAIN; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EMBRYOLOGY; FETAL DISEASES; FETUS DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PRENATAL EXPOSURE;

5-HYDROXYTRYPTOPHAN; ANIMALS; BRAIN; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FENCLONINE; FETAL DEVELOPMENT; FETAL DISEASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INFLAMMATION; MICE; PLACENTA; POLYDEOXYRIBONUCLEOTIDES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEROTONIN; SEROTONIN ANTAGONISTS; STATISTICS, NONPARAMETRIC;

EID: 84971655083     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2534-15.2016     Document Type: Article

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