Multiple sclerosis: The resolving lesion revealed

Journal of Neuroimmunology

Volumn 304, Issue , 2017, Pages 2-6

  Raine, Cedric S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Alternative activation; Foamy macrophages; Microglia; Multiple sclerosis; Regulatory mechanisms; Remyelination; Resolving plaque

Indexed keywords

MYELIN;

ARTICLE; CELL POPULATION; CELL SELF-RENEWAL; CLINICAL FEATURE; CLINICAL PROTOCOL; HUMAN; LYMPHOCYTIC INFILTRATION; MICROGLIA; MULTIPLE SCLEROSIS; REMYELINIZATION; WHITE MATTER; WOUND HEALING; ANIMAL; CEREBELLUM; MACROPHAGE; PATHOLOGY;

ANIMALS; CEREBELLUM; HUMANS; MACROPHAGES; MICROGLIA; MULTIPLE SCLEROSIS; WHITE MATTER;

EID: 84971654924     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2016.05.021     Document Type: Article

References (21)

1. Adams, R.D., Sidman, R.L., Adams, R.D., Sidman, R.L., (eds.) Introduction to Neuropathology, 1968, McGraw-Hill, New York, 149–170.
2. Allen, I.V., Demyelinating diseases. Adams, J.H., Corsellis, J.A.N., Duchen, L.W., (eds.) Greenfield's Neuropathology, IVth ed., 1984, Wiley, New York, 338–384.
3. Boven, L.A., Van Meurs, M., Van Zwan, M., Wierengar-Wolf, A., Hintzen, R.Q., Boot, R.G., Aerts, J.M., Amor, S., Nieuwenhuis, E.E., Laman, J.D., Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain 129 (2006), 517–526.
4. Colton, C.A., Mott, R.T., Sharpe, H., Xu, Q., Van Nostrand, W.E., Vitek, M.P., Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J. Neuroinflammation, 3, 2006, 27.
5. Davis, D.S., Carson, M.J., An introduction to CNS-resident microglia. Definitions, assays, and functional roles in health and disease. Cur, C., Grandison, L., Noroha, A., (eds.) Neural Immune Interactions in Brain Function and Alcohol-related Disorders, 2013, Springer (Publisher), New York, 3–29.
6. Dawson, J.W., The histology of disseminated sclerosis. Trans. R. Soc. Edinb. 50 (1916), 517–740.
7. Frohman, E.M., Racke, M.K., Raine, C.S., Multiple sclerosis: the plaque and its pathogenesis. N. Engl. J. Med. 354 (2006), 942–955.
8. Greenfield, J.G., Norman, R.M., Demyelinating diseases. Blackwood, W., McMenemey, W.H., Meyer, M., Norman, R.M., Russell, D.S., (eds.) Greenfield's Neuropathology, second ed., 1971, Arnold, London, 474–519.
9. Lassmann, H., Wekerle, H., The pathology of multiple sclerosis. Compston, A., Confavreux, C., Lassmann, H., McDonald, I., Miller, D., Noseworthy, J., Smith, K., Wekerle, H., (eds.) McAlpine's Multiple Sclerosis, fourth ed., 2005, Churchill/Livingston/Elsevier (Publishers), London, 557–599.
10. Ludwin, S.K., Raine, C.S., The neuropathology of multiple sclerosis. Raine, C.S., McFarland, H.F., Hohlfeld, R., (eds.) Multiple Sclerosis: A Comprehensive Text, 2008, Elsevier/Saunders (Publishers), London, 151–177.
11. Lumsden, C.E., The neuropathology of multiple sclerosis. Vinken, P.J., Bruyn, G.W., (eds.) Handbook of Clinical Neurology, Vol. 9, 1970, North Holland Publishing Company, Amsterdam, 217–309.
12. Mehta, V., Pei, W., Yang, G., Li, S., Swamy, E., Boster, A., Schmelbrock, P., Pitt, D., Iron is a sensitive biomarker for inflammation in multiple sclerosis lesions. PLoS One, 8, 2013, e57573.
13. Moore, G.R.W., Stadelmann-Nessler, C., Demyelinating diseases. Love, S., Perry, A., Ironside, J., Budka, H., (eds.) Greenfield's Neuropathology, nineth ed., 2015, CRC Press, Boca Raton, FL, 1297–1412.
14. Nimmerjahn, A., Kirchhoff, F., Helmchen, F., Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308 (2005), 1314–1318.
15. Prineas, J.W., Barnard, R.O., Kwon, E.E., Sharer, L.R., Cho, E.S., Remyelination of nascent lesions. Ann. Neurol. 33 (1993), 137–151.
16. Prineas, J.W., Bernard, R.O., Ervesz, T., Kwon, E.E., Sharer, L., Cho, E.S., Multiple sclerosis: pathology of recurrent lesions. Brain 116 (1993), 681–693.
17. Prineas, J.W., McDonald, W.I., Franklin, R.J.M., Demyelinating diseases. Graham, D.I., Lantos, P.L., (eds.), seventh ed. Greenfield's Neuropathology, vol. 2, 2002, Arnold, London, 471–535.
18. Raine, C.S., The neuropathology of multiple sclerosis. Raine, C.S., McFarland, H.F., Tourtellotte, W.W., (eds.) Multiple Sclerosis: Clinical and Pathogenetic Basis, 1997, Chapman and Hale, Publishers, London, 151–171.
19. Ransohoff, R.M., El Khoury, J., Microglia in health and disease. Cold Spring Harb. Perspect. Biol., 2015, 10.1101/cshperspect.a020560.
20. Rawji, K., Wee Yong, V., The benefits and detriments of microglia/macrophages in models of multiple sclerosis. Clin. Dev. Immunol., 2013, 10.1155/2013/948976.
21. Seitelberger, F., Pathology of multiple sclerosis. Ann. Clin. Res. 5 (1973), 337–344.