An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi

PLoS Neglected Tropical Diseases

Volumn 10, Issue 5, 2016, Pages

  O’Neill, Maeghan ^a   Mansour, Abdelmoneim ^b   DiCosty, Utami ^b   Geary, James ^c   Dzimianski, Michael ^b   McCall, Scott D ^b   McCall, John W ^b   Mackenzie, Charles D ^c   Geary, Timothy G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b TRS Labs Inc   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUBENDAZOLE; ANTINEMATODAL AGENT; MEBENDAZOLE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MOVEMENT; BRUGIAN FILARIASIS; COMPARATIVE STUDY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG BIOAVAILABILITY; DRUG EXPOSURE; EMBRYO DEVELOPMENT; FEMALE; FILARIASIS; HISTOLOGY; MALE; MERIONES UNGUICULATUS; MICROSCOPY; MORPHOLOGICAL TRAIT; NONHUMAN; PERITONEAL CAVITY; ANALOGS AND DERIVATIVES; ANIMAL; BRUGIA MALAYI; DRUG EFFECTS; GERBIL; PARASITOLOGY;

ANIMALS; ANTINEMATODAL AGENTS; BRUGIA MALAYI; FEMALE; GERBILLINAE; MALE; MEBENDAZOLE; PERITONEAL CAVITY;

EID: 84971641198     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004698     Document Type: Article

References (38)

1. Zeldenryk LM, Gray M, Speare R, Gordon S, Melrose W, (2011) The emerging story of disability associated with lymphatic filarisis: a critical review. PLoS Neglected Tropical Diseases.
2. Tyrell E, (2013) Socioeconomic burden of lymphatic filariasis in Georgetown, Guyana. Tropical Medical and International Health18: 152–158.
3. Molyneux DH, Zagaria N, (2002) Lymphatic filariasis elimination: progress in global programme development. Annals of tropical medicine and parasitology96: 15–40.
4. Dunn C, Callahan K, Katabarwa M, Richards F, Hopkins D, et al. (2015) The Contribution of Onchocerciasis Control and Elimination Programs toward the Achievement of the Millennium Development Goals. PLoS Negl Trop Dis.
5. Cupp EW, Sauerbrey M, Richards F, (2011) Elimination of human onchocerciasis: History of progress and current feasibility using ivermectin (Mectizan) monotherapy. Acta Tropica120, Supplement 1: S100–S108.
6. Shriram AN, Krishnamoorthy K, Sivan A, Saha BP, Kumaraswami V, et al. (2014) Impact of MDA and the prospects of elimination of the lone focus of diurnally sub periodic lymphatic filariasis in Nicobar Islands, India. Acta Tropica133: 93–97. doi: 10.1016/j.actatropica.2014.02.00424556139
7. Ramaiah KD, Ottensen EA, (2014) Progress and Impact of 13 Years of the Global Programme to Eliminate Lymphatic Filariasis on Reducing the Burden of Filarial Disease. PLoS Negl Trop Dis8: e3319. doi: 10.1371/journal.pntd.000331925412180
8. Evans DS, Alphonsus K, Umaru J, Eigege A, Miri E, et al. (2014) Administration for Onchocerciasis and Lymphatic Filariasis Elimination in Central Nigeria: Challenges in Coordinating the Stop MDA Decision. PLoS Negl Trop Dis8: e3113. doi: 10.1371/journal.pntd.000311325233351
9. Harrington H, Asugeni J, Jimuru C, Gwalaa J, Ribeyro E, et al. (2013) A practical strategy for responding to a case of lymphatic filariasis post-elimination in Pacific Islands. Parasites and Vectors6: 218. doi: 10.1186/1756-3305-6-21823890320
10. WHO (2015) From MDGs to SDGs: A new era for global public health 2016–2030. Available: http://wwwwhoint/mediacentre/events/meetings/2015/MDGs-SDGs-Summarypdf?ua=1: Accessed 28 September 2015.
11. Gardon J, Kamgno J, Folefack G, Gordon-Wendel N, Bouchite B, et al. (1997) Marked decreaes in the Loa loa microfilaraemia six and 12 months after a single dose of ivermectin. Transactions of the Royal Society of Tropical Medicine and Hygiene91: 593–594. 9463678
12. Bradley RE, Guerrero J, Becker HN, Michael BF, Newcomb K, (1983) Flubendazole: dose range and efficacy studies against common internal parasites of swine. Am J Vet Res44: 1329–1333. 6881670
13. Horton RJ, (1990) Benzimidazoles in a wormy world. Parasitology Today6: 106–106. 15463310
14. Yangco BG, Klein TW, Deresinski SC, Vickery AC, Craig CP, (1981) Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiases. Clin Ther4: 285–290. 7332916
15. Kan SP, (1983) The anthelmintic effects of flubendazole on Trichuris trichiura and Ascaris lumbricoides. Transactions of the Royal Society of Tropical Medicine and Hygiene77: 668–670. 6659046
16. Denham DA, Samad R, Cho SY, Suswillo RR, Skippins SC, (1979) The anthelmintic effects of flubendazole on Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene73: 673–676. 538808
17. Mak JW, (1981) Antifilarial activity of mebendazole and flubendazole on Breinlia booliati. Transactions of the Royal Society of Tropical Medicine and Hygiene75: 306–307. 7303142
18. Mackenzie CD, Geary TG, (2011) Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. Expert review of anti-infective therapy9: 497–501. doi: 10.1586/eri.11.3021609260
19. Dominguez-Vazquez A, Taylor HR, Greene BM, Ruvalcaba-Macias AM, Rivas-Alcala AR, et al. (1983) Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Lancet1: 139–143. 6130195
20. Ceballos L, Mackenzie CD, Geary TG, Alvarez L, Lanusse C, (2014) Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations. PLoS Negl Trop Dis8.
21. Longo M, Zanoncelli S, Messina M, Scandale I, Mackenzie C, et al. (2014) In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses. Reproductive Toxicology49: 33–42. doi: 10.1016/j.reprotox.2014.06.00924994687
22. O'Neill M, Geary JF, Agnew DW, Mackenzie CD, Geary TG, (2015) In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi International Journal for Parasitology: Drugs and Drug Resistance5: 135–140. doi: 10.1016/j.ijpddr.2015.06.00226288741
23. Moreno Y, Geary TG, (2008) Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products. PLoS neglected tropical diseases2.
24. Bennuru S, Semnani R, Meng Z, Ribeiro JMC, Veenstra TD, et al. (2009) Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling. PLoS Negl Trop Dis PLoS Neglected Tropical Diseases3: e410. doi: 10.1371/journal.pntd.000041019352421
25. Suswillo RRaD, D.A . (1977) A New System of Testing for Filaricidal Activity Using Transplanted Adult Brugia in the Jird. Journal of Parasitology63: 591–592. 864580
26. Schulz-Key H, (1988) The collagenase technique: how to isolate and examine adult Onchocerca volvulus for the evaluation of drug effects. Tropical Medical Parasitology39: 423–440.
27. Ceballos L, Alvarez L, Mackenzie C, Geary T, Lanusse C, (2015) Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule. International Journal for Parasitology: Drugs and Drug Resistance5: 178–184.
28. Ceballos L, Elissondo M, Bruni S, Denegri G, Alvarez L, et al. (2009) Flubendazole in cystic echinococcus therapy: Pharmaco-parasitological evaluation in mice. Parasitology International58: 354–358. doi: 10.1016/j.parint.2009.07.00619628054
29. Longo M, Zanoncelli S, Colombo P, Harhay M, Scandale I, et al. (2013) Effects of the benzimidazole anthelmintic drug flubendazole on rat embryos in vitro. Reproductive toxicology36: 78–87. doi: 10.1016/j.reprotox.2012.12.00423287076
30. Denham DA, Brandt E, (1980) Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds. Journal of Parasitology66: 933–934. 7218115
31. Lakshmi V, Joseph SK, Srivastava S, Verma SK, Sahoo MK, et al. (2010) Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi. Acta Tropica116: 127–133. doi: 10.1016/j.actatropica.2010.06.00620609356
32. Maizels RM, Denham DA, (1992) Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug. Parasitology105: S49–S60. 1308929
33. Bennett JL, Williams JF, Dave V, (1988) Pharmacology of ivermectin. Parasitology Today4: 226–228. 15463103
34. Franz M, Zahner H, Benten P, (1990) Fine-structure alterations in female Brugia malayi and Litomosoides carinii after in vivo treatment with flubendazole. Parasitology research76: 401–405. 2352917
35. Hanser E, Mehlhorn H, Hoeben D, Vlaminck K, (2003) In vitro studies on the effects of flubendazole against Toxocara canis and Ascaris suum. Parasitology research89: 63–74. 12474046
36. Forsyth KP, Mitchell GF, Copeman DB, (1984) Onchocerca gibsoni: increase of circulating egg antigen with chemotherapy in bovines. Experimental parasitology58: 41–55. 6547678
37. Rao RU, Huang Y, Abubucker S, Heinz M, Crosby SD, et al. (2012) Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo. J Biomed Sci19: 21. doi: 10.1186/1423-0127-19-2122321609
38. Denham DA, (1980) Anthelmintic properties of flubedazole against D. viteae in jirds. Transactions of the Royal Society of Tropical Medicine and Hygiene74: 829.