In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses

Reproductive Toxicology

Volumn 49, Issue , 2014, Pages 33-42

  Longo, Monica ^a   Zanoncelli, Sara ^a   Messina, Monica ^a   Scandale, Ivan ^b   Mackenzie, Charles ^c   Geary, Timothy ^d   Marsh, Kennan ^e   Lindley, David ^e   Mazué, Guy ^f  

^a Accelera Srl   (Italy)

^b Drugs for Neglected Diseases initiative (DND)   (Switzerland)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e ABBVIE INC   (United States)

^f Independent Consultant Aux Fermes de Bosne ^*  (France)

Author keywords

Benzimidazole anthelmintic; Embryolethality; Eye development; Filarial diseases; Flubendazole; Teratogenicity

Indexed keywords

BENZIMIDAZOLE; DRUG METABOLITE; FLUBENDAZOLE; POLYMER; ANTHELMINTIC AGENT; MEBENDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DEVELOPMENTAL TOXICITY; DRUG FORMULATION; DRUG HALF LIFE; EMBRYO; EMBRYO CELL; EMBRYO DEATH; EMBRYO DEVELOPMENT; EMBRYO GROWTH; EMBRYOTOXICITY; FEMALE; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; FETUS MALFORMATION; GESTATION PERIOD; IN VIVO STUDY; INTRAUTERINE GROWTH RETARDATION; LETHALITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING; TOXICOKINETICS; CONCENTRATION (PARAMETERS); GESTATIONAL AGE; GROWTH RETARDATION; HISTOLOGY; PREGNANCY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DOSE RESPONSE; DRUG EFFECTS; MAMMALIAN EMBRYO;

ANIMALS; ANTHELMINTICS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; FETUS; MEBENDAZOLE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84905238699     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.06.009     Document Type: Article

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