In vitro studies on the effects of flubendazole against Toxocara canis and Ascaris suum

Parasitology Research

Volumn 89, Issue 1, 2002, Pages 63-74

  Hanser, Elena ^a   Mehlhorn, Heinz ^a   Hoeben, Dagmar ^b   Vlaminck, Kathleen ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

FLUBENDAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ARTICLE; ASCARIS SUUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; FEMALE; GAMETE; IN VITRO STUDY; INCUBATION TIME; INTESTINE; MALE; MICROTUBULE ASSEMBLY; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE; TIME; TISSUE INJURY; TOXOCARA CANIS;

ANIMALIA; ASCARIS SUUM; CANIS; HYPODERRIS; NEMATODA; TOXOCARA; TOXOCARA CANIS;

EID: 0037213573     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0668-6     Document Type: Article

References (21)

1. Aubry ML, Cowell P, Davey MJ, Shevde S (1970) Aspects of the pharmacology of a new anthelmintic: Pyrantel. Br J Pharmacol 38:332-344
2. Austin WC, Courtney W, Danilewicz JC, Morgan DH, Conover LH, Howse Jun HL, Lynch JE, McFarland JW, Cornwell RL, Theodorides VJ (1966) Pyrantel tartrate, a new anthelmintic effective against infection in domestic animals. Nature 212:1273-1274
3. Barrowman MM, Marriner SE, Bogan JA (1984) The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics. Biochem Pharmacol 33:3037-3040
4. Becker B, Mehlhorn H, Andrews P, Thomas H (1981) Ultra-structural investigations on the effect of praziquantel on the tegument of five species of cestodes. Z Parasitenkd 64:257-269
5. Bughio NI, Faubert GM, Prichard RK (1994) Interaction of mebendazole with tubulin from body wall muscle, intestine, and reproductive system of Ascaris suum. J Parasitol 80:126-132
6. Denham DA, Samad R, Cho SY, Suswillo RR, Skippins SC (1979) The anthelmintic effects of flubendazole on Brugia pahangi. Trans R Soc Trop Med Hyg 73:673-676
7. Koehler P, Bachmann R (1981) Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes. Mol Biochem Parasitol 4:325-336
8. Lubega GW, Prichard RK (1990) Specific interaction of benzimidazole anthelmintics with tubulin: High-affinity binding and benzimidazole resistance in Haemonchus contortus. Mol Biochem Parasitol 38:221-232
9. Mackenstedt U, Schmidt S, Mehlhorn H, Stoye H, Traeder W (1993) Effects of pyrantel pamoate on adult and preadult Toxocara canis worms: A microscope and autoradiography study. Parasitol Res 79:567-578
10. Magambo JK (1996) Ascaris suum: Ultrastructural effect of in vitro albendazole therapy. East Afr Med J 73:140-142
11. Mehlhorn H (ed) (2001) Encyclopedic References of Parasitology, vols 1, 2. Springer, Berlin Heidelberg New York
12. Mehlhorn H, Harder A (1997) Effects of the synergistic action of febantel and pyrantel on the nematode Heterakis spumosa: A light and transmission electron microscopy study. Parasitol Res 83:419-34
13. Osman AM, Jacobs DE, Plummer JM (1994) In vivo effect of sublethal concentrations of albendazole metabolites on the structure of the reproductive organs of Dictyocaulus viviparus. J Helminthol 68:161-166
14. Prichard R (1994) Anthelmintic resistance. Vet Parasitol 54:259-268
15. Raether W (2001) Chemotherapy. In: Mehlhorn H (ed) Encyclopedic references of parasitology, vol 2. Springer, New York, pp 363-447
16. Reynolds ES (1969) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Biol 17:208-212
17. Sangster NC, Prichard RK, Lacey E (1985) Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (Nematoda) J Parasitol 71:645-651
18. Spurr AR (1969) A low viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 26:31-34
19. Sukontason K, Sukontason K, Piangjai S, Na-Bangchang K, Karbwang J (2000) Successful eradication of Ascaris lumbricoides and hookworm infection after three repeated doses of albendazole. J Med Assoc Thai 83:1095-1100
20. Vanparijs O, Hermans L, Van der Flaes L (1985) Anthelmintic efficacy of flubendazole paste against nematode and cestodes in dogs and cats. Am J Vet Res 46:2539-2541
21. Zintz K, Frank WC (1982) Ultrastructural modification in Heterakis spumosa after treatment with febantel or mebendazole. Vet Parasitol 10:47-56