Hyperthermia synergizes with chemotherapy by inhibiting PARP1-dependent DNA replication arrest

Cancer Research

Volumn 76, Issue 10, 2016, Pages 2868-2875

  Schaaf, Lea ^a   Schwab, Matthias ^a,b   Ulmer, Christoph ^c   Heine, Simon ^a   Murdter, Thomas E ^a   Schmid, Jens O ^a   Sauer, Georg ^c   Aulitzky, Walter E ^c   Van Der Kuip, Heiko ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c ROBERT BOSCH HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

A 966492; BRCA1 PROTEIN; BRCA2 PROTEIN; CISPLATIN; DNA; DOUBLE STRANDED DNA; DOXORUBICIN; HISTONE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; RUCAPARIB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; MESSENGER RNA; PARP1 PROTEIN, HUMAN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CANCER CHEMOTHERAPY; CANCER MODEL; CANCER SURVIVAL; COLON CANCER; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LONG TERM SURVIVAL; OVARY CANCER; PRIORITY JOURNAL; THERAPY EFFECT; THERMOTHERAPY; APOPTOSIS; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MULTIMODALITY CANCER THERAPY; OVARIAN NEOPLASMS; PATHOLOGY; PERITONEAL NEOPLASMS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CISPLATIN; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOXORUBICIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPERTHERMIA, INDUCED; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; POLY (ADP-RIBOSE) POLYMERASE-1; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84971554221     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-2908     Document Type: Article

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