A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development

Experimental Neurobiology

Volumn 24, Issue 1, 2015, Pages 8-16

  Hong, Sung Tae ^a   Mah, Won ^a,b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Brain Development; dGit; GIT1; Microcephaly

Indexed keywords

EID: 84971538129     PISSN: 12262560     EISSN: 20938144     Source Type: Journal    
DOI: 10.5607/en.2015.24.1.8     Document Type: Article

References (32)

1. Hoefen RJ, Berk BC (2006) The multifunctional GIT family of proteins. J Cell Sci 119:1469-1475.
2. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003) Interaction between liprin-Alpha and GIT1 is required for AMPA receptor targeting. J Neurosci 23:1667-1677.
3. Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003) Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol 161:131-142.
4. Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF (2005) A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci 25:3379-3388.
5. Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (2003) The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Biol Chem 278:6291-6300.
6. Kehoe LA, Bellone C, De Roo M, Zandueta A, Dey PN, Pérez-Otaño I, Muller D (2014) GluN3A promotes dendritic spine pruning and destabilization during postnatal development. J Neurosci 34:9213-9221.
7. Segura I, Essmann CL, Weinges S, Acker-Palmer A (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat Neurosci 10:301-310.
8. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC (2010) Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res 1317:218-226.
9. Cobos I, Borello U, Rubenstein JL (2007) Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron 54:873-888.
10. Won H, Mah W, Kim E, Kim JW, Hahm EK, Kim MH, Cho S, Kim J, Jang H, Cho SC, Kim BN, Shin MS, Seo J, Jeong J, Choi SY, Kim D, Kang C, Kim E (2011) GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med 17:566-572.
11. Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT (2014) GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Cell Rep 9:298-310.
12. Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (1998) PAK3 mutation in nonsyndromic X-linked mental retardation. Nat Genet 20: 25-30.
13. Peippo M , K oivisto AM, S ärkämö T, S ipponen M , v on Koskull H, Ylisaukko-oja T, Rehnström K, Froyen G, Ignatius J, Järvelä I (2007) PAK3 related mental disability: further characterization of the phenotype. Am J Med Genet A 143A: 2406-2416.
14. Huang W, Zhou Z, Asrar S, Henkelman M, Xie W, Jia Z (2011) p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties. Mol Cell Biol 31:388-403.
15. Walczak-Sztulpa J, Wisniewska M, Latos-Bielenska A, Linné M, Kelbova C , B elitz B, Pfeiffer L , Kalscheuer V, E rdogan F, Kuss AW, Ropers HH, Ullmann R, Tzschach A (2008) Chromosome deletions in 13q33-34: report of four patients and review of the literature. Am J Med Genet A 146A:337-342.
16. Chen L, Melendez J, Campbell K, Kuan CY, Zheng Y (2009) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol 325:162-170.
17. Sheu TJ, Zhou W, Fan J, Zhou H, Zuscik MJ, Xie C, Yin G, Berk BC (2014) Decreased BMP2 signal in GIT1 knockout mice slows bone healing. Mol Cell Biochem 397:67-74.
18. Xiao J, Chen X, Xu L, Zhang Y, Yin Q, Wang F (2014) Regulation of chondrocyte proliferation through GIT1-Rac1-mediated ERK1/2 pathway by PDGF. Cell Biol Int 38:695-701.
19. Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC (2009) G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation 119:1524-1532.
20. Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC (2014) Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. PLoS One 9:e89127.
21. Bahri SM, Choy JM, Manser E, Lim L, Yang X (2009) The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis. Dev Biol 325:15-23.
22. Parnas D, Haghighi AP, Fetter RD, Kim SW, Goodman CS (2001) Regulation of postsynaptic structure and protein localization by the Rho-Type guanine nucleotide exchange factor dPix. Neuron 32:415-424.
23. Hakeda-Suzuki S, Ng J, Tzu J, Dietzl G, Sun Y, Harms M, Nardine T, Luo L, Dickson BJ (2002) Rac function and regulation during Drosophila development. Nature 416:438-442.
24. Ozdowski EF, Gayle S, Bao H, Zhang B, Sherwood NT (2011) Loss of Drosophila melanogaster p21-Activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations. Genetics 189:123-135.
25. Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW (2000) Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations. Neuron 27:219-225.
26. Kloos AD, Fisher LC, Detloff MR, Hassenzahl DL, Basso DM (2005) Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Exp Neurol 191:251-265.
27. Hamers FP, Koopmans GC, Joosten EA (2006) CatWalk-Assisted gait analysis in the assessment of spinal cord injury. J Neurotrauma 23:537-548.
28. Woods CG (2004) Human microcephaly. Curr Opin Neurobiol 14:112-117.
29. Schmalzigaug R, Rodriguiz RM, Bonner PE, Davidson CE, Wetsel WC, Premont RT (2009) Impaired fear response in mice lacking GIT1. Neurosci Lett 458:79-83.
30. Davis RL (1993) Mushroom bodies and Drosophila learning. Neuron 11:1-14.
31. Mochida GH, Walsh CA (2001) Molecular genetics of human microcephaly. Curr Opin Neurol 14:151-156.
32. Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V (2014) A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. Cell Rep 7:1417-1425.