메뉴 건너뛰기




Volumn 397, Issue 1-2, 2014, Pages 67-74

Decreased BMP2 signal in GIT1 knockout mice slows bone healing

Author keywords

BMP2; Fracture healing; GIT1; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CARRIER PROTEINS AND BINDING PROTEINS; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 2 INTERACTING PROTEIN 1; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; BMP2 PROTEIN, MOUSE; CELL CYCLE PROTEIN; GIT1 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RUNX2 PROTEIN, MOUSE; SMAD PROTEIN; TGFB1 PROTEIN, MOUSE;

EID: 84912013484     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2173-5     Document Type: Article
Times cited : (16)

References (24)
  • 1
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    • PID: 12616527, COI: 1:CAS:528:DC%2BD3sXisVKktLs%3D
    • Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88:873–884. doi:10.1002/jcb.10435
    • (2003) J Cell Biochem , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 2
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn TA (1998) The cell and molecular biology of fracture healing. Clin Orthop Relat Res:S7-21
    • (1998) Clin Orthop Relat Res , pp. S7-S21
    • Einhorn, T.A.1
  • 3
    • 33947305450 scopus 로고    scopus 로고
    • Molecular aspects of fracture healing: which are the important molecules?
    • PID: 17383481
    • Tsiridis E, Upadhyay N, Giannoudis P (2007) Molecular aspects of fracture healing: which are the important molecules? Injury 38(Suppl 1):S11–S25. doi:10.1016/j.injury.2007.02.006
    • (2007) Injury , vol.38 , pp. S11-S25
    • Tsiridis, E.1    Upadhyay, N.2    Giannoudis, P.3
  • 4
    • 0036364515 scopus 로고    scopus 로고
    • The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis
    • PID: 12499240
    • Adams CS, Shapiro IM (2002) The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med 13:465–473
    • (2002) Crit Rev Oral Biol Med , vol.13 , pp. 465-473
    • Adams, C.S.1    Shapiro, I.M.2
  • 5
    • 84867896144 scopus 로고    scopus 로고
    • Angiogenesis is required for stress fracture healing in rats
    • PID: 23044046, COI: 1:CAS:528:DC%2BC38XhvVSlsbrI
    • Tomlinson RE, McKenzie JA, Schmieder AH, Wohl GR, Lanza GM, Silva MJ (2013) Angiogenesis is required for stress fracture healing in rats. Bone 52:212–219. doi:10.1016/j.bone.2012.09.035
    • (2013) Bone , vol.52 , pp. 212-219
    • Tomlinson, R.E.1    McKenzie, J.A.2    Schmieder, A.H.3    Wohl, G.R.4    Lanza, G.M.5    Silva, M.J.6
  • 6
    • 84927695975 scopus 로고    scopus 로고
    • FGF, TGFbeta and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells. J Tissue Eng Regen Med
    • Cleary MA, van Osch GJ, Brama PA, Hellingman CA and Narcisi R (2013) FGF, TGFbeta and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells. J Tissue Eng Regen Med. doi: 10.1002/term.1744
    • (2013) doi: 10.1002/term.1744
    • Cleary, M.A.1    van Osch, G.J.2    Brama, P.A.3    Hellingman, C.A.4    Narcisi, R.5
  • 7
    • 84865787544 scopus 로고    scopus 로고
    • Molecular pathways: targeting the TGF-beta pathway for cancer therapy
    • PID: 22711703, COI: 1:CAS:528:DC%2BC38Xht1ygsL3F
    • Smith AL, Robin TP, Ford HL (2012) Molecular pathways: targeting the TGF-beta pathway for cancer therapy. Clin Cancer Res 18:4514–4521. doi:10.1158/1078-0432.CCR-11-3224
    • (2012) Clin Cancer Res , vol.18 , pp. 4514-4521
    • Smith, A.L.1    Robin, T.P.2    Ford, H.L.3
  • 8
    • 47049122353 scopus 로고    scopus 로고
    • Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2
    • COI: 1:CAS:528:DC%2BD1cXoslOhu7w%3D
    • Freyria AM, Courtes S, Mallein-Gerin F (2008) Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2. Pathol Biol (Paris) 56:326–333. doi:10.1016/j.patbio.2007.09.010
    • (2008) Pathol Biol (Paris) , vol.56 , pp. 326-333
    • Freyria, A.M.1    Courtes, S.2    Mallein-Gerin, F.3
  • 9
    • 77953155161 scopus 로고    scopus 로고
    • Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals
    • PID: 20443623, COI: 1:CAS:528:DC%2BC3cXls1Shur4%3D
    • Lo YC, Chang YH, Wei BL, Huang YL, Chiou WF (2010) Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals. J Agric Food Chem 58:6643–6649. doi:10.1021/jf904158k
    • (2010) J Agric Food Chem , vol.58 , pp. 6643-6649
    • Lo, Y.C.1    Chang, Y.H.2    Wei, B.L.3    Huang, Y.L.4    Chiou, W.F.5
  • 10
    • 33646705915 scopus 로고    scopus 로고
    • The multifunctional GIT family of proteins
    • PID: 16598076, COI: 1:CAS:528:DC%2BD28XlsFelsrk%3D
    • Hoefen RJ, Berk BC (2006) The multifunctional GIT family of proteins. J Cell Sci 119:1469–1475. doi:10.1242/jcs.02925
    • (2006) J Cell Sci , vol.119 , pp. 1469-1475
    • Hoefen, R.J.1    Berk, B.C.2
  • 11
    • 42149101188 scopus 로고    scopus 로고
    • GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells
    • PID: 18292392, COI: 1:CAS:528:DC%2BD1cXktlylsrY%3D
    • Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC (2008) GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 28:892–898. doi:10.1161/ATVBAHA.107.161349
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 892-898
    • Pang, J.1    Yan, C.2    Natarajan, K.3    Cavet, M.E.4    Massett, M.P.5    Yin, G.6    Berk, B.C.7
  • 12
    • 0346095319 scopus 로고    scopus 로고
    • GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor
    • PID: 14701758, COI: 1:CAS:528:DC%2BD2cXktVyrsA%3D%3D
    • Yin G, Haendeler J, Yan C, Berk BC (2004) GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor. Mol Cell Biol 24:875–885
    • (2004) Mol Cell Biol , vol.24 , pp. 875-885
    • Yin, G.1    Haendeler, J.2    Yan, C.3    Berk, B.C.4
  • 13
    • 84866486120 scopus 로고    scopus 로고
    • GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing
    • PID: 22797318, COI: 1:CAS:528:DC%2BC38XhsFKmtL7F
    • Rui Z, Li X, Fan J, Ren Y, Yuan Y, Hua Z, Zhang N, Yin G (2012) GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing. Int J Mol Med 30:819–825. doi:10.3892/ijmm.2012.1058
    • (2012) Int J Mol Med , vol.30 , pp. 819-825
    • Rui, Z.1    Li, X.2    Fan, J.3    Ren, Y.4    Yuan, Y.5    Hua, Z.6    Zhang, N.7    Yin, G.8
  • 14
    • 84862811320 scopus 로고    scopus 로고
    • Phosphorylation of GIT1 tyrosine 321 is required for association with FAK at focal adhesions and for PDGF-activated migration of osteoblasts
    • PID: 22302306, COI: 1:CAS:528:DC%2BC38XmtVaqu7Y%3D
    • Ren Y, Yu L, Fan J, Rui Z, Hua Z, Zhang Z, Zhang N, Yin G (2012) Phosphorylation of GIT1 tyrosine 321 is required for association with FAK at focal adhesions and for PDGF-activated migration of osteoblasts. Mol Cell Biochem 365:109–118. doi:10.1007/s11010-012-1249-3
    • (2012) Mol Cell Biochem , vol.365 , pp. 109-118
    • Ren, Y.1    Yu, L.2    Fan, J.3    Rui, Z.4    Hua, Z.5    Zhang, Z.6    Zhang, N.7    Yin, G.8
  • 15
    • 77957738647 scopus 로고    scopus 로고
    • GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass
    • PID: 20568227, COI: 1:CAS:528:DC%2BC3cXhtFGqsL%2FI
    • Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC (2010) GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass. J Cell Physiol 225:777–785. doi:10.1002/jcp.22282
    • (2010) J Cell Physiol , vol.225 , pp. 777-785
    • Menon, P.1    Yin, G.2    Smolock, E.M.3    Zuscik, M.J.4    Yan, C.5    Berk, B.C.6
  • 16
    • 77957714046 scopus 로고    scopus 로고
    • Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells
    • PID: 20689073, COI: 1:CAS:528:DC%2BC3cXhtFKlsrjO
    • Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC (2010) Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30:1976–1982. doi:10.1161/ATVBAHA.110.212415
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1976-1982
    • Wang, J.1    Yin, G.2    Menon, P.3    Pang, J.4    Smolock, E.M.5    Yan, C.6    Berk, B.C.7
  • 18
    • 80455178772 scopus 로고    scopus 로고
    • ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
    • PID: 21764776, COI: 1:CAS:528:DC%2BC3MXhtlyqt7fE
    • Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K (2011) ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res 39:8712–8727. doi:10.1093/nar/gkr572
    • (2011) Nucleic Acids Res , vol.39 , pp. 8712-8727
    • Morikawa, M.1    Koinuma, D.2    Tsutsumi, S.3    Vasilaki, E.4    Kanki, Y.5    Heldin, C.H.6    Aburatani, H.7    Miyazono, K.8
  • 19
    • 30344435571 scopus 로고    scopus 로고
    • Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production
    • PID: 16400016, COI: 1:CAS:528:DC%2BD28XhtVKksb8%3D
    • Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR (2006) Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production. Am J Pathol 168:131–140
    • (2006) Am J Pathol , vol.168 , pp. 131-140
    • Tchetina, E.V.1    Antoniou, J.2    Tanzer, M.3    Zukor, D.J.4    Poole, A.R.5
  • 20
    • 0034962273 scopus 로고    scopus 로고
    • The perichondrium plays an important role in mediating the effects of TGF-beta1 on endochondral bone formation
    • PID: 11458391, COI: 1:CAS:528:DC%2BD3MXlt12hsLg%3D
    • Alvarez J, Horton J, Sohn P, Serra R (2001) The perichondrium plays an important role in mediating the effects of TGF-beta1 on endochondral bone formation. Dev Dyn 221:311–321. doi:10.1002/dvdy.1141
    • (2001) Dev Dyn , vol.221 , pp. 311-321
    • Alvarez, J.1    Horton, J.2    Sohn, P.3    Serra, R.4
  • 21
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • PID: 11285272, COI: 1:CAS:528:DC%2BD3MXisVyhtLw%3D
    • Yang X, Chen L, Xu X, Li C, Huang C, Deng CX (2001) TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol 153:35–46
    • (2001) J Cell Biol , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 22
    • 33846027131 scopus 로고    scopus 로고
    • BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    • PID: 17060321, COI: 1:CAS:528:DC%2BD28XhtlCrt7vJ
    • Hassan MQ, Tare RS, Lee SH, Mandeville M, Morasso MI, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB (2006) BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem 281:40515–40526. doi:10.1074/jbc.M604508200
    • (2006) J Biol Chem , vol.281 , pp. 40515-40526
    • Hassan, M.Q.1    Tare, R.S.2    Lee, S.H.3    Mandeville, M.4    Morasso, M.I.5    Javed, A.6    van Wijnen, A.J.7    Stein, J.L.8    Stein, G.S.9    Lian, J.B.10
  • 23
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    • PID: 9182762, COI: 1:CAS:528:DyaK2sXjs1ejsbg%3D
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747–754
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 24
    • 84870058734 scopus 로고    scopus 로고
    • Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation
    • PID: 22885149, COI: 1:CAS:528:DC%2BC38Xht1emt7zE
    • Sueyoshi T, Yamamoto K, Akiyama H (2012) Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation. Matrix Biol 31:352–359. doi:10.1016/j.matbio.2012.07.002
    • (2012) Matrix Biol , vol.31 , pp. 352-359
    • Sueyoshi, T.1    Yamamoto, K.2    Akiyama, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.