Niacin and olive oil promote skewing to the M2 phenotype in bone marrow-derived macrophages of mice with metabolic syndrome

Food and Function

Volumn 7, Issue 5, 2016, Pages 2233-2238

  Montserrat De La Paz, Sergio ^a   Naranjo, Maria C ^a   Lopez, Sergio ^a   Abia, Rocio ^a   Muriana, Francisco J G ^a   Bermudez, Beatriz ^b  

^a INSTITUTO DE LA GRASA   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BONE; CARBOXYLIC ACIDS; CHOLESTEROL; MACROPHAGES; MAMMALS; METABOLISM; NUTRITION; PYRIDINE; VEGETABLE OILS;

ANTI-INFLAMMATORIES; DIETARY SOURCES; FUNCTIONAL COMPETENCE; LONG CHAINS; METABOLIC SYNDROMES; PRO-INFLAMMATORY CYTOKINES; SERUM TRIGLYCERIDE; TYPE-2 DIABETES;

OLIVE OIL;

CHOLESTEROL; CYTOKINE; DOCOSAHEXAENOIC ACID; EDIBLE OIL; ICOSAPENTAENOIC ACID; MONOUNSATURATED FATTY ACID; NICOTINIC ACID; OLEIC ACID; OLIVE OIL; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; UNSATURATED FATTY ACID;

ANIMAL; BLOOD; BODY WEIGHT; C57BL MOUSE; DIET; DIET THERAPY; INFLAMMATION; MACROPHAGE; MALE; METABOLIC SYNDROME X; METABOLISM; MOUSE; PHENOTYPE;

ANIMALS; BODY WEIGHT; CHOLESTEROL; CYTOKINES; DIET; DIETARY FATS, UNSATURATED; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; INFLAMMATION; MACROPHAGES; MALE; METABOLIC SYNDROME; MICE; MICE, INBRED C57BL; NIACIN; OLEIC ACID; OLIVE OIL; PHENOTYPE; TRIGLYCERIDES;

EID: 84971343348     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c6fo00381h     Document Type: Article

References (19)

1. L. Ma B. H. Lee R. Mao A. Cai Y. Jia H. Clifton S. Schaefer L. Xu J. Zheng Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing Arterioscler., Thromb., Vasc. Biol. 2014 34 1272 1280
2. H. Vosper Niacin: a re-emerging pharmaceutical for the treatment of dyslipidaemia Br. J. Pharmacol. 2009 158 429 441
3. E. Zhou Y. Li M. Yao Z. Wei Y. Fu Z. Yang Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms Int. Immunopharmacol. 2014 23 121 126
4. D. Wanders E. C. Graff B. D. White R. L. Judd Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice PLoS One 2013 8 e71285
5. A. Dey J. Allen P. A. Hankey-Giblin Ontogeny and polarization of macrophages in inflammation: Blood monocytes versus tissue macrophages Front. Immunol. 2014 5 683
6. A. Ortega L. M. Varela B. Bermudez S. Lopez R. Abia F. J. Muriana Dietary fatty acids linking postprandial metabolic response and chronic diseases Food Funct. 2012 3 22 27
7. S. Montserrat-de la Paz M. C. Naranjo B. Bermudez S. Lopez W. Moreda R. Abia F. J. G. Muriana Postprandial dietary fatty acid exert divergent inflammatory response in retinal-pigmented epithelium cells Food Funct. 2016 7 1345 1354
8. A. J. Kennedy K. L. Ellacott V. L. King A. H. Hasty Mouse models of the metabolic syndrome Dis. Models Mech. 2010 3 156 166
9. L. M. Varela S. Lopez A. Ortega-Gomez B. Bermudez I. Buers H. Robenek F. J. G. Muriana R. Abia Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages J. Nutr. Biochem. 2015 26 327 336
10. S. Montserrat-de la Paz R. De la Puerta A. Fernandez-Arche A. M. Quilez F. J. Muriana M. D. Garcia-Gimenez B. Bermudez Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2 macrophages J. Ethnopharmacol. 2015 170 128 135
11. N. Hariri R. Gougeon L. Thibault A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content Nutr. Res. 2010 30 632 643
12. K. R. Feingold J. K. Shigenaga M. R. Kazemi C. M. McDonald S. M. Patzek A. S. Cross A. Moser C. Grunfeld Mechanisms of triglyceride accumulation in activated macrophages J. Leukocyte Biol. 2012 92 829 839
13. K. R. Feingold A. Moser J. K. Shigenaga C. Grunfeld Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages J. Lipid Res. 2014 55 2501 2508
14. A. Jindal S. Bruzzi S. Sutti I. Locatelli C. Bozzola C. Paternostro M. Parola E. Albano Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH) Exp. Mol. Pathol. 2015 99 155 162
15. M. R. Dasu I. Jialal Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors Am. J. Physiol.: Endocrinol. Metab. 2011 300 E145 E154
16. M. R. Dasu S. Ramirez R. R. Isseroff Toll-like receptors and diabetes: a therapeutic perspective Clin. Sci. 2012 122 203 214
17. AIM-HIGH investigators W. E. Boden I. L. Probstfield T. Anderson et al., Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy N. Engl. J. Med. 2011 365 2255 2267
18. HPS2-THRIVE Collaborative Group R. Haynes L. Jiang J. C. Hopewell et al., HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment Eur. Heart J. 2013 34 1279 1291
19. HPS2-THRIVE Collaborative Group M. J. Landray R. Haynes J. C. Hopewell et al., Effects of extended-release niacin with laropiprant in high-risk patients N. Engl. J. Med. 2014 371 203 212