Spatial Ion Peak Compression and its Utility in Ion Mobility Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 27, Issue 6, 2016, Pages 1128-1135

  Garimella, Sandilya V B ^a   Ibrahim, Yehia M ^a   Tang, Keqi ^a   Webb, Ian K ^a   Baker, Erin S ^a   Tolmachev, Aleksey V ^a   Chen, Tsung Chi ^a   Anderson, Gordon A ^a   Smith, Richard D ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Diffusion; High resolution IMS; Ion mobility spectrometry; Peak compression

Indexed keywords

DIFFUSION; ELECTRIC FIELDS; INERTIAL CONFINEMENT FUSION; IONS; NUMERICAL METHODS; SPECTROMETRY;

DIFFUSION DRIVEN; HIGH RESOLUTION; ION DISTRIBUTIONS; ION MOBILITY SPECTROMETRY; PEAK BROADENING; PEAK COMPRESSION; PEAK INTENSITY; TEMPORAL DOMAIN;

ION MOBILITY SPECTROMETERS;

ION;

ARTICLE; COMPRESSION; DENSITY; DIFFUSION COEFFICIENT; ELECTRIC FIELD; ELECTRODE; ION MOBILITY SPECTROMETRY; ION SPATIAL PEAK COMPRESSION; VELOCITY; PRESSURE;

ION MOBILITY SPECTROMETRY; IONS; PRESSURE;

EID: 84971299218     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-016-1371-7     Document Type: Article

References (45)

1. Hoaglund, C.S., Valentine, S.J., Sporleder, C.R., Reilly, J.P., Clemmer, D.E.: Three-dimensional ion mobility/TOFMS analysis of electrosprayed biomolecules. Anal. Chem. 70, 2236–2242 (1998)
2. Collins, D.C., Xiang, Y., Lee, M.L.: Comprehensive ultra-high pressure capillary liquid chromatography/ion mobility spectrometry. Chromatographia 55, 123–128 (2002)
3. Eckers, C., Laures, A.M.F., Giles, K., Major, H., Pringle, S.: Evaluating the utility of ion mobility separation in combination with high-pressure liquid chromatography/mass spectrometry to facilitate detection of trace impurities in formulated drug products. Rapid Commun. Mass Spectrom. 21, 1255–1263 (2007)
4. Bronsema, K.J., Bischoff, R., van de Merbel, N.C.: High-sensitivity LC-MS/MS quantification of peptides and proteins in complex biological samples: the impact of enzymatic digestion and internal standard selection on method performance. Anal. Chem. 85, 9528–9535 (2013)
5. Baker, E.S., Livesay, E.A., Orton, D.J., Moore, R.J., Danielson, W.F., 3rd, Prior, D.C., Ibrahim, Y.M., LaMarche, B.L., Mayampurath, A.M., Schepmoes, A.A., Hopkins, D.F., Tang, K., Smith, R.D., Belov, M.E.: An LC-IMS-MS platform providing increased dynamic range for high-throughput proteomic studies. J. Proteome Res. 9, 997–1006 (2010)
6. Bohrer, B.C., Mererbloom, S.I., Koeniger, S.L., Hilderbrand, A.E., Clemmer, D.E.: Biomolecule analysis by ion mobility spectrometry. Annu. Rev. Palo Alto 1, 293–327 (2008)
7. Kemper, P.R., Dupuis, N.F., Bowers, M.T.: A new, higher resolution, ion mobility mass spectrometer. Int. J. Mass Spectrom. 287, 46–57 (2009)
8. Merenbloom, S.I., Glaskin, R.S., Henson, Z.B., Clemmer, D.E.: High-resolution ion cyclotron mobility spectrometry. Anal. Chem. 81, 1482–1487 (2009)
9. Baker, E.S., Clowers, B.H., Li, F.M., Tang, K., Tolmachev, A.V., Prior, D.C., Belov, M.E., Smith, R.D.: Ion mobility spectrometry-mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures. J. Am. Soc. Mass Spectrom. 18, 1176–1187 (2007)
10. Belov, M.E., Buschbach, M.A., Prior, D.C., Tang, K.Q., Smith, R.D.: Multiplexed ion mobility spectrometry-orthogonal time-of-flight mass spectrometry. Anal. Chem. 79, 2451–2462 (2007)
11. Davis, E.J., Dwivedi, P., Tam, M., Siems, W.F., Hill, H.H.: High-pressure ion mobility spectrometry. Anal. Chem. 81, 3270–3275 (2009)
12. Shvartsburg, A.A., Smith, R.D.: Accelerated high-resolution differential ion mobility separations using hydrogen. Anal. Chem. 83, 9159–9166 (2011)
13. Bhardwaj, C., Hanley, L.: Ion sources for mass spectrometric identification and imaging of molecular species. Nat. Prod. Rep. 31, 756–767 (2014)
14. Covey, T.R., Thomson, B.A., Schneider, B.B.: Atmospheric pressure ion sources. Mass Spectrom. Rev. 28, 870–897 (2009)
15. Du, Y.Z., Wang, W.G., Li, H.Y.: Resolution enhancement of ion mobility spectrometry by improving the three-zone properties of the Bradbury-Nielsen gate. Anal. Chem. 84, 1725–1731 (2012)
16. Mason, E.A., McDaniel, E.W.: Federal Republic of Germany. Wiley-VCH Verlag, Weinheim (1988)
17. Verbeck, G.F., Ruotolo, B.T., Gillig, K.J., Russell, D.H.: Resolution equations for high-field ion mobility. J. Am. Soc. Mass Spectrom. 15, 1320–1324 (2004)
18. Shvartsburg, A.A., Smith, R.D.: Protein analyses using differential ion mobility microchips with mass spectrometry. Anal. Chem. 84, 7297–7300 (2012)
19. Shvartsburg, A.A., Tang, K.Q., Smith, R.D.: FAIMS operation for realistic gas flow profile and asymmetric waveforms including electronic noise and ripple. J. Am. Soc. Mass Spectrom. 16, 1447–1455 (2005)
20. Scarff, C.A., Thalassinos, K., Hilton, G.R., Scrivens, J.H.: Traveling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements. Rapid Commun. Mass Spectrom. 22, 3297–3304 (2008)
21. Shvartsburg, A.A., Smith, R.D.: Fundamentals of traveling wave ion mobility spectrometry. Anal. Chem. 80, 9689–9699 (2008)
22. Valentine, S.J., Stokes, S.T., Kurulugama, R.T., Nachtigall, F.M., Clemmer, D.E.: Overtone mobility spectrometry: Part 2. Theoretical considerations of resolving power. J. Am. Soc. Mass Spectrom. 20, 738–750 (2009)
23. Kurulugama, R.T., Nachtigall, F.M., Lee, S., Valentine, S.J., Clemmer, D.E.: Overtone mobility spectrometry: Part 1. Experimental observations. J. Am. Soc. Mass Spectrom. 20, 729–737 (2009)
24. Glaskin, R.S., Valentine, S.J., Clemmer, D.E.: A scanning frequency mode for ion cyclotron mobility spectrometry. Anal. Chem. 82, 8266–8271 (2010)
25. Glaskin, R.S., Ewing, M.A., Clemmer, D.E.: Ion trapping for ion mobility spectrometry measurements in a cyclical drift tube. Anal. Chem. 85, 7003–7008 (2013)
26. Moskovets, E.V.: Line-shape of mass peaks in a reflectron with plane metal grids. Appl. Phys. B-Photo. 57, 397–403 (1993)
27. Zhang, X.Y., Garimella, S.V.B., Prost, S.A., Webb, I.K., Chen, T.C., Tang, K.Q., Tolmachev, A.V., Norheim, R.V., Baker, E.S., Anderson, G.A., Ibrahim, Y.M., Smith, R.D.: Ion trapping, storage, and ejection in structures for lossless ion manipulations. Anal. Chem. 87, 6010–6016 (2015)
28. Garimella, S.V.B., Ibrahim, Y.M., Webb, I.K., Ipsen, A.B., Chen, T.C., Tolmachev, A.V., Baker, E.S., Anderson, G.A., Smith, R.D.: Ion manipulations in structures for lossless ion manipulations (SLIM): computational evaluation of a 90° turn and a switch. Analyst 14, 6845–6852 (2015)
29. Webb, I.K., Garimella, S.V.B., Tolmachev, A.V., Chen, T.C., Zhang, X.Y., Norheim, R.V., Prost, S.A., LaMarche, B., Anderson, G.A., Ibrahim, Y.M., Smith, R.D.: Experimental evaluation and optimization of structures for loss less ion manipulations for ion mobility spectrometry with time-of-flight mass spectrometry. Anal. Chem. 86, 9169–9176 (2014)
30. Webb, I.K., Garimella, S.V.B., Tolmachev, A.V., Chen, T.C., Zhang, X.Y., Cox, J.T., Norheim, R.V., Prost, S.A., LaMarche, B., Anderson, G.A., Ibrahim, Y.M., Smith, R.D.: Mobility-resolved ion selection in uniform drift field ion mobility spectrometry/mass spectrometry: dynamic switching in structures for lossless ion manipulations. Anal. Chem. 86, 9632–9637 (2014)
31. Tolmachev, A.V., Webb, I.K., Ibrahim, Y.M., Garimella, S.V.B., Zhang, X.Y., Anderson, G.A., Smith, R.D.: Characterization of ion dynamics in structures for lossless ion manipulations. Anal. Chem. 86, 9162–9168 (2014)
32. Garimella, S.V.B., Ibrahim, Y.M., Webb, I.K., Tolmachev, A.V., Zhang, X.Y., Prost, S.A., Anderson, G.A., Smith, R.D.: Simulation of electric potentials and ion motion in planar electrode structures for lossless ion manipulations (SLIM). J. Am. Soc. Mass Spectrom. 25, 1890–1896 (2014)
33. Hamid, A.M., Ibrahim, Y.M., Garimella, S.V.B., Webb, I.K., Deng, L., Chen, T.-C., Anderson, G.A., Prost, S.A., Norheim, R.V., Tolmachev, A.V., Smith, R.D.: Characterization of traveling wave ion mobility separations in structures for lossless ion manipulations. Anal. Chem. 87, 11301–11308 (2015)
34. Laiko, V.V.: Orthogonal extraction ion mobility spectrometry. J. Am. Soc. Mass Spectrom. 17, 500–507 (2006)
35. Garimella, S., Xu, W., Huang, G.M., Harper, J.D., Cooks, R.G., Ouyang, Z.: Gas-flow assisted ion transfer for mass spectrometry. J. Mass Spectrom. 47, 201–207 (2012)
36. Tannehill, J.C., Anderson, D.A.: Pletcher. R.H. Taylor and Francis, Philadelphia (1997)
37. Ibrahim, Y., Tang, K., Tolmachev, A.V., Shvartsburg, A.A., Smith, R.D.: Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface. J. Am. Soc. Mass Spectrom. 17, 1299–1305 (2006)
38. Ibrahim, Y., Belov, M.E., Tolmachev, A.V., Prior, D.C., Smith, R.D.: Ion funnel trap interface for orthogonal time-of-flight mass spectrometry. Anal. Chem. 79, 7845–7852 (2007)
39. Ibrahim, Y.M., Prior, D.C., Baker, E.S., Smith, R.D., Belov, M.E.: Characterization of an ion mobility-multiplexed collision induced dissociation-tandem time-of-flight mass spectrometry approach. Int. J. Mass Spectrom. 293, 34–44 (2010)
40. Ibrahim, Y.M., Shvartsburg, A.A., Smith, R.D., Belov, M.E.: Ultrasensitive identification of localization variants of modified peptides using ion mobility spectrometry. Anal. Chem. 83, 5617–5623 (2011)
41. Ewing, M.A., Zucker, S.M., Valentine, S.J., Clemmer, D.E.: Overtone mobility spectrometry: Part 5. Simulations and analytical expressions describing overtone limits. J. Am. Soc. Mass Spectrom. 24, 615–621 (2013)
42. Ewing, M.A., Conant, C.R.P., Zucker, S.M., Griffith, K.J., Clemmer, D.E.: Selected overtone mobility spectrometry. Anal. Chem. 87, 5132–5138 (2015)
43. Prasad, S., Tang, K., Manura, D., Papanastasiou, D., Smith, R.D.: Simulation of ion motion in FAIMS through combined use of SIMION and modified SDS. Anal. Chem. 81, 8749–8757 (2009)
44. Shvartsburg, A.A., Smith, R.D.: Optimum waveforms for differential ion mobility spectrometry (FAIMS). J. Am. Soc. Mass Spectrom. 19, 1286–1295 (2008)
45. May, J.C., McLean, J.A.: Ion mobility-mass spectrometry: time-dispersive instrumentation. Anal. Chem. 87, 1422–1436 (2015)