The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial

Journal of the Neurological Sciences

Volumn 367, Issue , 2016, Pages 18-21

  Deng, Q Q ^a   Tang, J ^b   Chen, C ^c   Markus, H ^d   Huang, Y N ^e   Zhao, H ^f   Ratanakorn, D ^g   Wong, K S L ^h   Fu, J H ^b,i  

^a Hospital of Shanghai   (China)

^b FUDAN UNIVERSITY   (China)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d ST GEORGE S HOSPITAL   (United Kingdom)

^e PEKING UNIVERSITY FIRST HOSPITAL   (China)

^f WENZHOU MEDICAL UNIVERSITY   (China)

^g MAHIDOL UNIVERSITY   (Thailand)

^h CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

ⁱ Pudong Hospital   (China)

Author keywords

Aspirin; Clopidogrel; Large artery stenosis; Microembolic signals; The relative intensity; Transcranial doppler

Indexed keywords

ACETYLSALICYLIC ACID; BIOLOGICAL MARKER; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

ADULT; ARTERY OCCLUSION; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FOLLOW UP; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MICROEMBOLIC SIGNAL; MICROEMBOLISM; MIDDLE AGED; MONOTHERAPY; PRIORITY JOURNAL; RECURRENT DISEASE; TRANSCRANIAL DOPPLER; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; TRANSIENT ISCHEMIC ATTACK; ANALOGS AND DERIVATIVES; CAROTID STENOSIS; CEREBRAL ARTERIAL DISEASES; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DIAGNOSTIC IMAGING; INTRACRANIAL EMBOLISM; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STROKE; TREATMENT OUTCOME;

ASPIRIN; BRAIN ISCHEMIA; CAROTID STENOSIS; CEREBRAL ARTERIAL DISEASES; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRACRANIAL EMBOLISM; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RECURRENCE; SINGLE-BLIND METHOD; STROKE; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84971291440     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2016.05.042     Document Type: Article

References (19)

1. P.M. Rothwell, A. Buchan, and S.C. Johnston Recent advances in management of transient ischaemic attacks and minor ischaemic strokes Lancet Neurol. 5 2006 323 331
2. H.S. Markus, D.W. Droste, M. Kaps, V. Larrue, K.R. Lees, M. Siebler, and et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (caress) trial Circulation 111 2005 2233 2240
3. J. Kennedy, M.D. Hill, K.J. Ryckborst, M. Eliasziw, A.M. Demchuk, and A.M. Buchan Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (faster): a randomised controlled pilot trial Lancet Neurol. 6 2007 961 969
4. M.I. Chimowitz, M.J. Lynn, H. Howlett-Smith, B.J. Stern, V.S. Hertzberg, M.R. Frankel, and et al. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis N. Engl. J. Med. 352 2005 1305 1316
5. K.S. Wong, C. Chen, P.W. Ng, T.H. Tsoi, H.L. Li, W.C. Fong, and et al. Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in asian patients with large artery occlusive disease: a randomised study Lancet Neurol. 6 2007 407 413
6. S.U. Kwon, Y.J. Cho, J.S. Koo, H.J. Bae, Y.S. Lee, K.S. Hong, and et al. Cilostazol prevents the progression of the symptomatic intracranial arterial stenosis: the multicenter double-blind placebo-controlled trial of cilostazol in symptomatic intracranial arterial stenosis Stroke 36 2005 782 786
7. J.D. Spence, A. Tamayo, S.P. Lownie, W.P. Ng, and G.G. Ferguson Absence of microemboli on transcranial doppler identifies low-risk patients with asymptomatic carotid stenosis Stroke 36 2005 2373 2378
8. A.D. Mackinnon, R. Aaslid, and H.S. Markus Ambulatory transcranial doppler cerebral embolic signal detection in symptomatic and asymptomatic carotid stenosis Stroke 36 2005 1726 1730
9. A.L. Abbott, B.R. Chambers, J.L. Stork, C.R. Levi, C.F. Bladin, and G.A. Donnan Embolic signals and prediction of ipsilateral stroke or transient ischemic attack in asymptomatic carotid stenosis: a multicenter prospective cohort study Stroke 36 2005 1128 1133
10. H.S. Markus, and A. MacKinnon Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis Stroke 36 2005 971 975
11. S. Gao, K.S. Wong, T. Hansberg, W.W. Lam, D.W. Droste, and E.B. Ringelstein Microembolic signal predicts recurrent cerebral ischemic events in acute stroke patients with middle cerebral artery stenosis Stroke 35 2004 2832 2836
12. K.S. Wong, C. Chen, J. Fu, H.M. Chang, N.C. Suwanwela, Y.N. Huang, and et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (clair study): a randomised, open-label, blinded-endpoint trial Lancet Neurol. 9 2010 489 497
13. Z.B. Jovanovic, A.M. Pavlovic, J.J. Zidverc-Trajkovic, M.D. Mijajlovic, A.P. Radojicic, and N.M. Covickovic-Sternic Transcranial doppler test for evaluation of cerebral artery embolism-microemboli detection Srp. Arh. Celok. Lek. 136 2008 302 306
14. M.A. Almekhlafi, A.M. Demchuk, S. Mishra, S. Bal, B.K. Menon, S. Wiebe, and et al. Malignant emboli on transcranial doppler during carotid stenting predict postprocedure diffusion-weighted imaging lesions Stroke 44 2013 1317 1322
15. M.J. Martin, E.M. Chung, K.V. Ramnarine, A.H. Goodall, A.R. Naylor, and D.H. Evans Thrombus size and doppler embolic signal intensity Cerebrovasc. Dis. 28 2009 397 405
16. D. Russell, K.P. Madden, W.M. Clark, P.M. Sandset, and J.A. Zivin Detection of arterial emboli using doppler ultrasound in rabbits Stroke 22 1991 253 258
17. V.A. Kiri, and G. MacKenzie How real is intention-to-treat (itt) analysis in non-interventional post authorization safety studies? We can do better Curr Drug Saf. 4 2009 137 142
18. H.C. Diener, J. Bogousslavsky, L.M. Brass, C. Cimminiello, L. Csiba, M. Kaste, and et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (match): randomised, double-blind, placebo-controlled trial Lancet 364 2004 331 337
19. G. Telman, E. Sprecher, and E. Kouperberg Potential relevance of low-intensity microembolic signals by tcd monitoring Neurol. Sci. 32 2011 107 111