Comparative biochemical studies of fresh frozen plasma and pooled solvent/detergent-treated plasma (octaplasLG®) with focus on protein S and its impact in different thrombin generation assay set-ups

Vox Sanguinis

Volumn 111, Issue 3, 2016, Pages 266-273

  Heger, A ^a   Janisch, S ^a   Pock, K ^a   Romisch J ^a  

^a Octapharma Pharmazeutika Produktions GmbH   (Austria)

Author keywords

FFP; octaplasLG; protein S; S D plasma; TGA; thromboelastometry

Indexed keywords

ACTIVATED PROTEIN C; DETERGENT; FRESH FROZEN PLASMA; OCTAPLAS; PHOSPHOLIPID; PROTEIN S; SOLVENT; THROMBOPLASTIN; THROMBIN;

ANTICOAGULATION; ARTICLE; BIOCHEMICAL ANALYSIS; BLOOD ANALYSIS; BLOOD CLOTTING PARAMETERS; CLINICAL EVALUATION; COMPARATIVE STUDY; CONCENTRATION PROCESS; HUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; THROMBIN GENERATION ASSAY; THROMBIN TIME; THROMBOELASTOGRAPHY; BLOOD CLOTTING; CHEMISTRY; DRUG EFFECTS; METABOLISM; PLASMA;

BLOOD COAGULATION; DETERGENTS; HUMANS; PLASMA; PROTEIN S; SOLVENTS; THROMBELASTOGRAPHY; THROMBIN;

EID: 84971282373     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12420     Document Type: Article

References (30)

1. Dargaud Y, Sorensen B, Shima M, et al.: Global haemostasis and point of care testing. Haemophilia 2012; 18:81–88
2. Devreese K, Wijns W, Combes I, et al.: Thrombin generation in plasma of healthy adults and children: chromogenic versus fluorogenic thrombogram analysis. Thromb Haemost 2007; 98:600–613
3. Whiting D, DiNardo JA: TEG and ROTEM: technology and clinical applications. Am J Hematol 2014; 89:228–232
4. Spahn DR, Bouillon B, Cerny V, et al.: Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 2013; 17:R76
5. Young G, Sorensen B, Darguad Y, et al.: Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives. Blood 2013; 121:1944–1950
6. Ingerslev J, Poulsen LH, Sorensen B: Potential role of the dynamic properties of whole blood coagulation in assessment of dosage requirements in haemophilia. Haemophilia 2003; 9:348–352
7. Bagot CN, Leishman E: Establishing a reference range for thrombin generation using a standard plasma significantly improves assay precision. Thromb Res 2015; 136:139–143
8. Schneider T, Siegemund T, Siegemund R, et al.: Thrombin generation and rotational thromboelastometry in the healthy adult population. Hamostaseologie 2015; 35:181–186
9. Rodgers SE, Wong A, Gopal RD, et al.: Evaluation of pre-analytical variables in a commercial thrombin generation assay. Thromb Res 2014; 134:160–164
10. Machlus KR, Colby EA, Wu JR, et al.: Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost 2009; 102:936–944
11. Wayne L, Chandler MD, Roshal M: Optimization of plasma fluorogenic thrombin-generation assays. Am J Clin Pathol 2009; 132:169–179
12. Ganter M, Hofer CK: Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulant devices. Anesth Analg 2008; 106:1366–1375
13. Gerotziafas GT, Depasse F, Bussin J, et al.: Towards standardization of thrombin generation assessment: the influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay. Thromb J 2005; 3:16–26
14. Pintao MC, Ribeiro DD, Bezemer ID, et al.: Protein S levels and the risk of venous thrombosis: results from the MRGA case-control study. Blood 2013; 122:3210–3219
15. Lijfering WM, Mulder R, ten Kate MK, et al.: Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relatives. Blood 2009; 113:1225–1230
16. Koster T, Rosendaal FR, Briet E, et al.: Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study). Blood 1995; 85:2756–2761
17. Lawrie AS, Cardigan RA, Williamson LM, et al.: The dynamics of clot formation in fresh frozen plasma. Vox Sang 2008; 94:306–314
18. Schols SEM, Feijge MAH, Lancé MD, et al.: Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography: partly compensating role of platelets. Transfusion 2008; 48:2384–2394
19. Lawrie AS, Green L, Canciani MT, et al.: The effect of prion reduction in solvent/detergent-treated plasma on haemostatic variables. Vox Sang 2010; 99:232–238
20. ®) and a development product (Uniplas). Transfus Apher Sci 2007; 37:223–231
21. Pitkänen H, Jouppila A, Mowinckel M-C, et al.: Enhanced thrombin generation and reduced intact protein S in processed solvent detergent plasma. Thromb Res 2015; 135:167–174
22. Sc) removal technology and reduction of the solvent/detergent (S/D) process time. Vox Sang 2009; 97:219–225
23. Coene J, Devreese K, Sabot B, et al.: Paired analysis of plasma proteins and coagulant capacity after treatment with three methods of pathogen reduction. Transfusion 2014; 54:1321–1331
24. Mackie I, Cooper P, Lawrie A, et al.: Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis. Int J Lab Hematol 2012; 35:1–13
25. European Pharmacopoeia Commission – Council of Europe European Department for the Quality of Medicines: Human plasma (pooled and treated for virus inactivation). Eur Pharmacopoeia 2009; 1646:4168–4170
26. De Smedt E, Dieri RA, Spronk HMH, et al.: The technique of measuring thrombin generation with fluorogenic substrates: I. Necessity of adequate calibration. Thromb Haemost 2008; 100:343–349
27. Flamholz R, Jeon HR, Baron JM, et al.: Study of three patients with thrombotic thrombocytopenic purpura exchanged with solvent/detergent-treated plasma: is its decreased protein S activity clinically related to their development of deep venous thromboses? J Clin Apher 2000; 15:169–172
28. Solheim BG, Hellstern P: Composition, efficacy, and safety of S/D treated plasma. Transfusion 2003; 43:1176–1178
29. Salge-Bartels U, Breitner-Ruddock S, Hunfeld A, et al.: Are quality differences responsible for different adverse reactions reported for SD-plasma from USA and Europe? Transfus Med 2006; 16:266–275
30. Yarranton H, Cohen H, Pavord SR, et al.: Venous thromboembolism associated with the management of acute thrombotic thrombocytopenic purpura. Br J Haematol 2003; 121:778–785