Therapy-induced cellular senescence induces epithelial-to-mesenchymal transition and increases invasiveness in rectal cancer

Clinical Colorectal Cancer

Volumn 15, Issue 2, 2016, Pages 170-178.e3

  Tato Costa, Joana ^a   Casimiro, Sandra ^a   Pacheco, Teresa ^a   Pires, Ricardo ^a,b   Fernandes, Afonso ^a   Alho, Irina ^a   Pereira, Pedro ^a   Costa, Paulo ^b   Castelo, Henrique Bicha ^b   Ferreira, João ^a   Costa, Luís ^a,b  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

5 Fluorouracil; Neoadjuvant chemotherapy; Rectal cancer; Senescence associated secretory phenotype; Therapy induced senescence

Indexed keywords

DOXORUBICIN; FLUOROURACIL; MESSENGER RNA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; VIMENTIN; ANTINEOPLASTIC AGENT;

ADJUVANT CHEMORADIOTHERAPY; ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURGERY; CELL INVASION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HCT116 CELL LINE; HEALTH CARE QUALITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LASER MICRODISSECTION; MAJOR CLINICAL STUDY; MALE; RECTUM CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; TUMOR INVASION; CELL AGING; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; HCT 116 CELL LINE; LASER CAPTURE MICRODISSECTION; MIDDLE AGED; PATHOLOGY; RECTUM TUMOR; TUMOR MICROENVIRONMENT; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CELL AGING; DOXORUBICIN; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FLUOROURACIL; HCT116 CELLS; HUMANS; LASER CAPTURE MICRODISSECTION; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; RECTAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT;

EID: 84971280900     PISSN: 15330028     EISSN: 19380674     Source Type: Journal    
DOI: 10.1016/j.clcc.2015.09.003     Document Type: Article

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