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Angewandte Chemie - International Edition

Volumn 55, Issue 28, 2016, Pages 7948-7951

The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody–Drug Conjugates

(9) Kolakowski, Robert V a Haelsig, Karl T a Emmerton, Kim K a Leiske, Chris I a Miyamoto, Jamie B a Cochran, Julia H a Lyon, Robert P a Senter, Peter D a Jeffrey, Scott C a

a SEATTLE GENETICS INC (United States)

Author keywords

alcohols; antibodies; cancer; drug delivery; glycoconjugate

Indexed keywords

ALCOHOLS; ANTIBODIES; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; PH; PHYSIOLOGICAL MODELS;

BETA-GLUCURONIDASE; CANCER; DRUG-CONJUGATES; GLYCOCONJUGATES; MODELING CONSTRUCT; PHYSIOLOGICAL PH; SPECIFIC ACTIVITY; TARGETED DELIVERY;

TARGETED DRUG DELIVERY;

AMINOBENZOIC ACID DERIVATIVE; ANTIBODY CONJUGATE; AURISTATIN; CARBAMIC ACID DERIVATIVE; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; OLIGOPEPTIDE; PHENYLPROPANOLAMINE; TUBULIN MODULATOR;

ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; HODGKIN DISEASE; HUMAN; MOUSE; NEOPLASM; TUMOR CELL LINE;

AMINOBENZOATES; ANIMALS; ANTINEOPLASTIC AGENTS, IMMUNOLOGICAL; CARBAMATES; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; HODGKIN DISEASE; HUMANS; IMMUNOCONJUGATES; MICE; NEOPLASMS; OLIGOPEPTIDES; PHENYLPROPANOLAMINE; TUBULIN MODULATORS;

EID: 84971267989 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201601506 Document Type: Article

Times cited : (59)

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