The spalt transcription factors regulate cell proliferation, survival and epithelial integrity downstream of the Decapentaplegic signalling pathway

Biology Open

Volumn 2, Issue 1, 2013, Pages 37-48

  Organista, María F ^a   De Celis, Jose F ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cell death; Dpp signalling; Drosophila; Imaginal discs; Spalt; Wing

Indexed keywords

EID: 84970967293     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20123038     Document Type: Article

References (41)

1. Affolter, M. and Basler, K. (2007). The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat. Rev. Genet. 8, 663-674.
2. Barrio, R., de Celis, J. F., Bolshakov, S. and Kafatos, F. C. (1999). Identification of regulatory regions driving the expression of the Drosophila spalt complex at different developmental stages. Dev. Biol. 215, 33-47.
3. Burke, R. and Basler, K. (1996). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269.
4. Cantera, R., Lüer, K., Rusten, T. E., Barrio, R., Kafatos, F. C. and Technau, G. M. (2002). Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster. Development 129, 5577-5586.
5. Cruz, C., Glavic, A., Casado, M. and de Celis, J. F. (2009). A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics 183, 1005-1026.
6. de Celis, J. F. (2003). Pattern formation in the Drosophila wing: The development of the veins. Bioessays 25, 443-451.
7. de Celis, J. F. and Barrio, R. (2000). Function of the spalt/spalt-related gene complex in positioning the veins in the Drosophila wing. Mech. Dev. 91, 31-41.
8. de Celis, J. F. and Barrio, R. (2009). Regulation and function of Spalt proteins during animal development. Int. J. Dev. Biol. 53, 1385-1398.
9. de Celis, J. F. and Bray, S. (1997). Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124, 3241-3251.
10. de Celis, J. F., Barrio, R. and Kafatos, F. C. (1996). A gene complex acting downstream of dpp in Drosophila wing morphogenesis. Nature 381, 421-424.
11. de Celis, J. F., Barrio, R. and Kafatos, F. C. (1999). Regulation of the spalt/spaltrelated gene complex and its function during sensory organ development in the Drosophila thorax. Development 126, 2653-2662.
12. Dietzl, G., Chen, D., Schnorrer, F., Su, K. C., Barinova, Y., Fellner, M., Gasser, B., Kinsey, K., Oppel, S., Scheiblauer, S. et al. (2007). A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448, 151-156.
13. Domingos, P. M., Brown, S., Barrio, R., Ratnakumar, K., Frankfort, B. J., Mardon, G., Steller, H. and Mollereau, B. (2004). Regulation of R7 and R8 differentiation by the spalt genes. Dev. Biol. 273, 121-133.
14. Dong, P. D., Todi, S. V., Eberl, D. F. and Boekhoff-Falk, G. (2003). Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes. Proc. Natl. Acad. Sci. USA 100, 10293-10298.
15. Edgar, B. A. and O'Farrell, P. H. (1989). Genetic control of cell division patterns in the Drosophila embryo. Cell 57, 177-187.
16. Gelbart, W. M., Crosby, M., Matthews, B., Rindone, W. P., Chillemi, J., Russo Twombly, S., Emmert, D., Ashburner, M., Drysdale, R. A., Whitfield, E. et al. (1997). FlyBase: a Drosophila database. Nucleic Acids Res. 25, 63-66.
17. Gibson, M. C. and Perrimon, N. (2005). Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307, 1785-1789.
18. Gould, A. P., Elstob, P. R. and Brodu, V. (2001). Insect oenocytes: a model system for studying cell-fate specification by Hox genes. J. Anat. 199, 25-33.
19. Ito, K., Awano, W., Suzuki, K., Hiromi, Y. and Yamamoto, D. (1997). The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development 124, 761-771.
20. Jaźwińska, A., Kirov, N., Wieschaus, E., Roth, S. and Rushlow, C. (1999). The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 96, 563-573.
21. Kühnlein, R. P. and Schuh, R. (1996). Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development. Development 122, 2215-2223.
22. Kühnlein, R. P., Frommer, G., Friedrich, M., Gonzalez-Gaitan, M., Weber, A., Wagner-Bernholz, J. F., Gehring, W. J., Jäckle, H. and Schuh, R. (1994). spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J. 13, 168-179.
23. Lauberth, S. M., Bilyeu, A. C., Firulli, B. A, Kroll, K. L. and Rauchman, M. (2007). A phosphomimetic mutation in the Sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of Gbx2. J. Biol. Chem. 282, 34858-34868.
24. Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H. and Cohen, S. M. (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.
25. Martín-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A. M. and Martinez-Arias, A. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12, 557-570.
26. Martín-Castellanos, C. and Edgar, B. A. (2002). A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development 129, 1003-1013.
27. Massagué, J. and Wotton, D. (2000). Transcriptional control by the TGF-b/Smad signaling system. EMBO J. 19, 1745-1754.
28. Milán, M., Campuzano, S. and García-Bellido, A. (1997). Developmental parameters of cell death in the wing disc of Drosophila. Proc. Natl. Acad. Sci. USA 94, 5691-5696.
29. Milán, M., Pérez, L. and Cohen, S. M. (2002). Short-range cell interactions and cell survival in the Drosophila wing. Dev. Cell 2, 797-805.
30. Mollereau, B., Dominguez, M., Webel, R., Colley, N. J., Keung, B., de Celis, J. F. and Desplan, C. (2001). Two-step process for photoreceptor formation in Drosophila. Nature 412, 911-913.
31. Nellen, D., Burke, R., Struhl, G. and Basler, K. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.
32. O'Farrell, P. H., Edgar, B. A., Lakich, D. and Lehner, C. F. (1989). Directing cell division during development. Science 246, 635-640.
33. Resino, J., Salama-Cohen, P. and García-Bellido, A. (2002). Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing. Proc. Natl. Acad. Sci. USA 99, 7502-7507.
34. Rogulja, D. and Irvine, K. D. (2005). Regulation of cell proliferation by a morphogen gradient. Cell 123, 449-461.
35. Rusten, T. E., Cantera, R., Urban, J., Technau, G., Kafatos, F. C. and Barrio, R. (2001). Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes. Development 128, 711-722.
36. Sánchez, J., Talamillo, A., González, M., Sánchez-Pulido, L., Jiménez, S., Pirone, L., Sutherland, J. D. and Barrio, R. (2011). Drosophila Sal and Salr are transcriptional repressors. Biochem. J. 438, 437-445.
37. Schwank, G., Restrepo, S. and Basler, K. (2008). Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development 135, 4003-4013.
38. Sweetman, D. and Münsterberg, A. (2006). The vertebrate spalt genes in development and disease. Dev. Biol. 293, 285-293.
39. Teleman, A. A. and Cohen, S. M. (2000). Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103, 971-980.
40. Wu, Q., Chen, X., Zhang, J., Loh, Y. H., Low, T. Y., Zhang, W., Zhang, W., Sze, S. K., Lim, B. and Ng, H. H. (2006). Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J. Biol. Chem. 281, 24090-24094.
41. Xu, T. and Rubin, G. M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.